KR20110099111A - 돌연변이된 ｒｘｘｄ 모티프를 포함하는 디구아닐레이트 시클라제를 사용하는, 시클릭 디구아노신 모노포스페이트의 효소적 제조 방법 - Google Patents
돌연변이된 ｒｘｘｄ 모티프를 포함하는 디구아닐레이트 시클라제를 사용하는, 시클릭 디구아노신 모노포스페이트의 효소적 제조 방법 Download PDFInfo
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- KR20110099111A KR20110099111A KR1020117014319A KR20117014319A KR20110099111A KR 20110099111 A KR20110099111 A KR 20110099111A KR 1020117014319 A KR1020117014319 A KR 1020117014319A KR 20117014319 A KR20117014319 A KR 20117014319A KR 20110099111 A KR20110099111 A KR 20110099111A
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- dgc
- gmp
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- gtp
- mutant
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/36—Dinucleotides, e.g. nicotineamide-adenine dinucleotide phosphate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Organic Chemistry (AREA)
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- Microbiology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12092508P | 2008-12-09 | 2008-12-09 | |
| EP08171026 | 2008-12-09 | ||
| US61/120,925 | 2008-12-09 | ||
| EP08171026.1 | 2008-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20110099111A true KR20110099111A (ko) | 2011-09-06 |
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Family Applications (1)
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| KR1020117014319A Withdrawn KR20110099111A (ko) | 2008-12-09 | 2009-12-07 | 돌연변이된 ｒｘｘｄ 모티프를 포함하는 디구아닐레이트 시클라제를 사용하는, 시클릭 디구아노신 모노포스페이트의 효소적 제조 방법 |
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| US (1) | US20110288286A1 (enExample) |
| EP (1) | EP2376634A1 (enExample) |
| JP (1) | JP2012511313A (enExample) |
| KR (1) | KR20110099111A (enExample) |
| CN (1) | CN102245774A (enExample) |
| AR (1) | AR074495A1 (enExample) |
| AU (1) | AU2009326306B2 (enExample) |
| BR (1) | BRPI0923296A2 (enExample) |
| CA (1) | CA2747127A1 (enExample) |
| TW (1) | TW201033367A (enExample) |
| UY (1) | UY32307A (enExample) |
| WO (1) | WO2010066666A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6047143B2 (ja) | 2012-02-29 | 2016-12-21 | ヤマサ醤油株式会社 | ｃｙｃｌｉｃｄｉ−ＧＭＰの実践的酵素合成法 |
| CN113122593A (zh) * | 2019-12-31 | 2021-07-16 | 安徽古特生物科技有限公司 | 一种利用多聚磷酸盐制备核苷三磷酸和脱氧核苷三磷酸的方法 |
| CN111647611A (zh) * | 2020-07-02 | 2020-09-11 | 杭州美亚药业股份有限公司 | 一种双鸟苷酸环化酶改造基因、编码蛋白、工程菌及其构建方法和应用 |
| CN117701596B (zh) * | 2023-12-08 | 2026-07-03 | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 一种大量合成天然环二鸟苷酸的基因工程菌及其应用 |
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| US6037145A (en) * | 1994-09-07 | 2000-03-14 | Suntory Limited | Process for production of protein |
| JP3995279B2 (ja) * | 1994-09-07 | 2007-10-24 | アスビオファーマ株式会社 | 蛋白の製造方法 |
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2009
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- 2009-12-07 CA CA2747127A patent/CA2747127A1/en not_active Abandoned
- 2009-12-07 JP JP2011540039A patent/JP2012511313A/ja active Pending
- 2009-12-07 KR KR1020117014319A patent/KR20110099111A/ko not_active Withdrawn
- 2009-12-07 BR BRPI0923296-6A patent/BRPI0923296A2/pt not_active IP Right Cessation
- 2009-12-07 US US13/133,458 patent/US20110288286A1/en not_active Abandoned
- 2009-12-07 CN CN2009801489188A patent/CN102245774A/zh active Pending
- 2009-12-07 EP EP09764839A patent/EP2376634A1/en not_active Withdrawn
- 2009-12-07 TW TW098141714A patent/TW201033367A/zh unknown
- 2009-12-07 WO PCT/EP2009/066492 patent/WO2010066666A1/en not_active Ceased
- 2009-12-07 AU AU2009326306A patent/AU2009326306B2/en not_active Ceased
- 2009-12-08 UY UY0001032307A patent/UY32307A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010066666A1 (en) | 2010-06-17 |
| US20110288286A1 (en) | 2011-11-24 |
| CA2747127A1 (en) | 2010-06-17 |
| CN102245774A (zh) | 2011-11-16 |
| UY32307A (es) | 2010-02-26 |
| BRPI0923296A2 (pt) | 2015-08-11 |
| AU2009326306A1 (en) | 2010-06-17 |
| TW201033367A (en) | 2010-09-16 |
| JP2012511313A (ja) | 2012-05-24 |
| AR074495A1 (es) | 2011-01-19 |
| EP2376634A1 (en) | 2011-10-19 |
| AU2009326306B2 (en) | 2012-12-13 |
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