BRPI0923296A2 - Diguanilato ciclase mutante, método para a fabricação de diguanilato ciclase mutante, processo para a produção de monofosfato de diguanosina cíclico, e, lote - Google Patents

Diguanilato ciclase mutante, método para a fabricação de diguanilato ciclase mutante, processo para a produção de monofosfato de diguanosina cíclico, e, lote

Info

Publication number
BRPI0923296A2
BRPI0923296A2 BRPI0923296-6A BRPI0923296A BRPI0923296A2 BR PI0923296 A2 BRPI0923296 A2 BR PI0923296A2 BR PI0923296 A BRPI0923296 A BR PI0923296A BR PI0923296 A2 BRPI0923296 A2 BR PI0923296A2
Authority
BR
Brazil
Prior art keywords
diguanylate cyclase
mutant diguanylate
batch
manufacture
production
Prior art date
Application number
BRPI0923296-6A
Other languages
English (en)
Inventor
Thomas Simon Ilg
Volker Spehr
Ralf Warrass
Original Assignee
Intervet Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet Int Bv filed Critical Intervet Int Bv
Publication of BRPI0923296A2 publication Critical patent/BRPI0923296A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/36—Dinucleotides, e.g. nicotineamide-adenine dinucleotide phosphate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
BRPI0923296-6A 2008-12-09 2009-12-07 Diguanilato ciclase mutante, método para a fabricação de diguanilato ciclase mutante, processo para a produção de monofosfato de diguanosina cíclico, e, lote BRPI0923296A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12092508P 2008-12-09 2008-12-09
EP08171026 2008-12-09
PCT/EP2009/066492 WO2010066666A1 (en) 2008-12-09 2009-12-07 Process for the enzymatic production of cyclic diguanosine monophosphate employing a diguanylate cyclase comprising a mutated rxxd motif

Publications (1)

Publication Number Publication Date
BRPI0923296A2 true BRPI0923296A2 (pt) 2015-08-11

Family

ID=40602165

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0923296-6A BRPI0923296A2 (pt) 2008-12-09 2009-12-07 Diguanilato ciclase mutante, método para a fabricação de diguanilato ciclase mutante, processo para a produção de monofosfato de diguanosina cíclico, e, lote

Country Status (12)

Country Link
US (1) US20110288286A1 (pt)
EP (1) EP2376634A1 (pt)
JP (1) JP2012511313A (pt)
KR (1) KR20110099111A (pt)
CN (1) CN102245774A (pt)
AR (1) AR074495A1 (pt)
AU (1) AU2009326306B2 (pt)
BR (1) BRPI0923296A2 (pt)
CA (1) CA2747127A1 (pt)
TW (1) TW201033367A (pt)
UY (1) UY32307A (pt)
WO (1) WO2010066666A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9650615B2 (en) 2012-02-29 2017-05-16 Yamasa Corporation Practical method for enzymatically synthesizing cyclic di-GMP
CN113122593A (zh) * 2019-12-31 2021-07-16 安徽古特生物科技有限公司 一种利用多聚磷酸盐制备核苷三磷酸和脱氧核苷三磷酸的方法
CN111647611A (zh) * 2020-07-02 2020-09-11 杭州美亚药业股份有限公司 一种双鸟苷酸环化酶改造基因、编码蛋白、工程菌及其构建方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037145A (en) * 1994-09-07 2000-03-14 Suntory Limited Process for production of protein
JP3995279B2 (ja) * 1994-09-07 2007-10-24 アスビオファーマ株式会社 蛋白の製造方法

Also Published As

Publication number Publication date
TW201033367A (en) 2010-09-16
JP2012511313A (ja) 2012-05-24
AU2009326306A1 (en) 2010-06-17
CN102245774A (zh) 2011-11-16
EP2376634A1 (en) 2011-10-19
WO2010066666A1 (en) 2010-06-17
CA2747127A1 (en) 2010-06-17
US20110288286A1 (en) 2011-11-24
UY32307A (es) 2010-02-26
AU2009326306B2 (en) 2012-12-13
AR074495A1 (es) 2011-01-19
KR20110099111A (ko) 2011-09-06

Similar Documents

Publication Publication Date Title
BRPI0910916A2 (pt) Processo para a produção de um dianidroaçúcar
BRPI0917984A2 (pt) processo em batelada para a produção de poliamidas
BRPI0912846A2 (pt) Aparelho para a produção de um artigo de fumo, processo de produção de um artigo de fumo, programa de computador e máquina.
BRPI0913622A2 (pt) Processo para a produção fermentativa de eritropoietina
BRPI1013615A2 (pt) camada funcional elétrica, processo de produção e uso dela
BRPI0810488A2 (pt) Aparelho para produção de biocoque, método para controle e processo para produção do mesmo
BRPI0920414A2 (pt) Processo para a produção de alfa-tocotrienal e seus derivados
BRPI0812239A2 (pt) Método de produção de artigo de vidro revestido, e produto intermediário usado no mesmo
WO2013087073A3 (de) Substrat mit einer strukturierten oberfläche sowie verfahren zu dessen herstellung sowie verfahren zur bestimmung der benetzungseigenschaften davon
BR112012003615A2 (pt) processo para a produção de butadieno
BRPI0818887A2 (pt) Processo de produção de açúcares
BRPI0810452A2 (pt) Processo para a produção de composições de betume
BRPI0922934A2 (pt) Processo para a produção de bio-óleo a partir de biomassa, e, bio-óleo
BRPI0906249A2 (pt) Processo de elaboração de 1,1,1,4,4,4-hexafluoro-2-buteno
BRPI1013296A2 (pt) processo para a produção de polidienos
BRPI0915572A2 (pt) processo para a fabricação de epicloroidrina
BRPI1010128A2 (pt) "processo para a fabricação do 2,3,3,3 - tetrafluropropeno"
BR112013014105A2 (pt) material compósito, composição e processo para produzir um material compósito, e, método de usar o material compósito
BRPI0906901A2 (pt) Processo para a recuperação de hcl de uma solução diluída do mesmo, processo para a produção de carboidratos e composição.
IT1395068B1 (it) Processo per la produzione di galatto-oligosaccaridi ultrapuri
BRPI0915571A2 (pt) processo para à fabricação de um 1,2-epóxido
BR112012001937A2 (pt) método para a produção de 2,2-difluoroetilamina
BRPI0918980A2 (pt) Produto de confeitaria, processo e aparelho de produção
BRPI0815784A2 (pt) Processo para a preparação de 1,2-propanodiol
BRPI0806679A2 (pt) Processo aperfeiçoado de produção de alquilaromático

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]