KR20110073494A - 시냅스 소포 순환 검정 및 시스템 - Google Patents

시냅스 소포 순환 검정 및 시스템 Download PDF

Info

Publication number
KR20110073494A
KR20110073494A KR1020117007795A KR20117007795A KR20110073494A KR 20110073494 A KR20110073494 A KR 20110073494A KR 1020117007795 A KR1020117007795 A KR 1020117007795A KR 20117007795 A KR20117007795 A KR 20117007795A KR 20110073494 A KR20110073494 A KR 20110073494A
Authority
KR
South Korea
Prior art keywords
platform
synaptic vesicle
wells
neuronal cells
range
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020117007795A
Other languages
English (en)
Korean (ko)
Inventor
데이비드 제이. 거버
제프리 알. 코트렐
티모시 에이. 리안
조나단 엠. 레벤슨
Original Assignee
갈레네아 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 갈레네아 코포레이션 filed Critical 갈레네아 코포레이션
Publication of KR20110073494A publication Critical patent/KR20110073494A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Electrochemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Peptides Or Proteins (AREA)
KR1020117007795A 2008-09-04 2009-08-31 시냅스 소포 순환 검정 및 시스템 Ceased KR20110073494A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9436108P 2008-09-04 2008-09-04
US61/094,361 2008-09-04

Publications (1)

Publication Number Publication Date
KR20110073494A true KR20110073494A (ko) 2011-06-29

Family

ID=41479300

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117007795A Ceased KR20110073494A (ko) 2008-09-04 2009-08-31 시냅스 소포 순환 검정 및 시스템

Country Status (8)

Country Link
US (2) US20120053084A1 (cg-RX-API-DMAC7.html)
EP (1) EP2329275A2 (cg-RX-API-DMAC7.html)
JP (2) JP5789513B2 (cg-RX-API-DMAC7.html)
KR (1) KR20110073494A (cg-RX-API-DMAC7.html)
CN (1) CN102203622A (cg-RX-API-DMAC7.html)
AU (2) AU2009288657A1 (cg-RX-API-DMAC7.html)
CA (1) CA2744804C (cg-RX-API-DMAC7.html)
WO (1) WO2010027446A2 (cg-RX-API-DMAC7.html)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2254458A1 (en) * 2008-02-04 2010-12-01 Bayer HealthCare, LLC Semiconductor based analyte sensors and methods
US9217155B2 (en) 2008-05-28 2015-12-22 University Of Massachusetts Isolation of novel AAV'S and uses thereof
US8734809B2 (en) 2009-05-28 2014-05-27 University Of Massachusetts AAV's and uses thereof
CN103168236B (zh) 2010-08-23 2016-01-20 哈佛大学管理委员会 用于膜电位测定的光遗传学探针
US9207237B2 (en) 2010-08-23 2015-12-08 President And Fellows Of Harvard College Systems, methods, and workflows for optogenetics analysis
US9488637B2 (en) * 2011-01-26 2016-11-08 The Curators Of The University Of Missouri Combination of single-cell electroporation and electrical recording using the same electrode
CA2870511C (en) 2011-04-21 2023-08-08 University Of Massachusetts Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies
WO2013078347A2 (en) * 2011-11-23 2013-05-30 President And Fellows Of Harvard College Systems and methods for imaging at high spatial and/or temporal precision
US9696275B2 (en) 2012-10-12 2017-07-04 The Curators Of The University Of Missouri Addressable electrode arrays in multiple fluidic compartments and uses thereof
EP2913391B1 (en) * 2012-10-25 2020-07-01 Hamamatsu Photonics K.K. Cell observation device, and cell observation method
US9778189B2 (en) 2012-10-25 2017-10-03 Hamamatsu Photonics K.K. Cell observation device, electrical stimulation device, and cell observation method
JP6370544B2 (ja) * 2013-11-11 2018-08-08 浜松ホトニクス株式会社 細胞観察装置及び細胞観察方法
US10415010B2 (en) 2014-01-16 2019-09-17 Hamamatsu Photonics K.K. Cell observation device, electrostimulation device, and cell observation method
WO2015127128A2 (en) 2014-02-19 2015-08-27 University Of Massachusetts Recombinant aavs having useful transcytosis properties
EP4410805A3 (en) 2014-03-18 2024-11-27 University of Massachusetts Raav-based compositions and methods for treating amyotrophic lateral sclerosis
US9594075B2 (en) 2014-04-22 2017-03-14 Q-State Biosciences, Inc. Diagnostic methods for neural disorders
EP3134522B1 (en) 2014-04-25 2021-10-06 University of Massachusetts Recombinant aav vectors useful for reducing immunity against transgene products
US9518103B2 (en) 2014-06-18 2016-12-13 President And Fellows Of Harvard College Optogenetic probes for measuring membrane potential
SG11201701540PA (en) 2014-08-28 2017-03-30 Stemonix Inc Method of fabricating cell arrays and uses thereof
WO2016054554A1 (en) 2014-10-03 2016-04-07 University Of Massachusetts Heterologous targeting peptide grafted aavs
JP6842410B2 (ja) 2014-10-03 2021-03-17 ユニバーシティ オブ マサチューセッツ 新規の高効率ライブラリーにより同定されるａａｖベクター
RU2738421C2 (ru) 2014-10-21 2020-12-14 Юниверсити Оф Массачусетс Варианты рекомбинантных aav и их применения
WO2016115333A1 (en) 2015-01-15 2016-07-21 President And Fellows Of Harvard College Optical selection of cells
EP3256170B1 (en) 2015-02-13 2020-09-23 University of Massachusetts Compositions and methods for transient delivery of nucleases
US10048275B2 (en) 2015-03-13 2018-08-14 Q-State Biosciences, Inc. Cardiotoxicity screening methods
CA3019315A1 (en) 2015-04-23 2016-10-27 University Of Massachusetts Modulation of aav vector transgene expression
US11046955B2 (en) 2015-04-24 2021-06-29 University Of Massachusetts Modified AAV constructs and uses thereof
US11248212B2 (en) 2015-06-30 2022-02-15 StemoniX Inc. Surface energy directed cell self assembly
US10760053B2 (en) 2015-10-15 2020-09-01 StemoniX Inc. Method of manufacturing or differentiating mammalian pluripotent stem cells or progenitor cells using a hollow fiber bioreactor
WO2017070516A1 (en) 2015-10-22 2017-04-27 University Of Massachusetts Prostate-targeting adeno-associated virus serotype vectors
EP3364997B1 (en) 2015-10-22 2024-01-17 University of Massachusetts Aspartoacylase gene therapy in the treatment of canavan disease
US11826433B2 (en) 2016-02-02 2023-11-28 University Of Massachusetts Method to enhance the efficiency of systemic AAV gene delivery to the central nervous system
EP3413928B1 (en) 2016-02-12 2022-04-20 University of Massachusetts Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization
EP3225279B1 (en) * 2016-03-31 2023-12-20 Université de Rennes Brain tissue stimulation apparatus and computer program
US11207426B2 (en) 2016-04-05 2021-12-28 University Of Massachusetts Compositions and methods for selective inhibition of grainyhead-like protein expression
US11413356B2 (en) 2016-04-15 2022-08-16 University Of Massachusetts Methods and compositions for treating metabolic imbalance
US11882815B2 (en) 2016-06-15 2024-01-30 University Of Massachusetts Recombinant adeno-associated viruses for delivering gene editing molecules to embryonic cells
US10457940B2 (en) 2016-09-22 2019-10-29 University Of Massachusetts AAV treatment of Huntington's disease
WO2018071831A1 (en) 2016-10-13 2018-04-19 University Of Massachusetts Aav capsid designs
WO2018208972A1 (en) 2017-05-09 2018-11-15 University Of Massachusetts Methods of treating amyotrophic lateral sclerosis (als)
EP3684937A4 (en) 2017-09-22 2021-06-02 University of Massachusetts NEW DUAL SOD1 EXPRESSION VECTORS AND RELATED USES
CA3096102A1 (en) 2018-04-13 2019-10-17 University Of Massachusetts Bicistronic aav vectors encoding hexosaminidase alpha and beta-subunits and uses thereof
JP7065433B2 (ja) * 2018-08-14 2022-05-12 日本電信電話株式会社 電極及びその製造方法、並びに積層体
JP7709201B2 (ja) 2018-10-05 2025-07-16 ユニバーシティ オブ マサチューセッツ ＧＭ１ガングリオシドーシスおよびＧＭ２ガングリオシドーシスの処置のためのｒＡＡＶベクター
AU2020314729B2 (en) * 2019-07-16 2023-07-06 Meso Scale Technologies, Llc. Assay apparatuses, methods and reagents
JP2024501849A (ja) * 2020-12-31 2024-01-16 キュー－ステート バイオサイエンシーズ， インコーポレイテッド 光学プレートコントローラおよびリーダ
EP4271978A4 (en) 2020-12-31 2024-12-18 Q-State Biosciences, Inc. MICROSCOPE WITH SPATIAL IMAGING AND BEAM HOMOGENIZER
WO2022146981A1 (en) * 2020-12-31 2022-07-07 Q-State Biosciences, Inc. Plate imager
EP4271994A4 (en) 2020-12-31 2024-11-27 Q-State Biosciences, Inc. Calibrating and normalizing imager for optogenetics
JP2024516303A (ja) * 2021-05-04 2024-04-12 キュー－ステート バイオサイエンシーズ， インコーポレイテッド 薬物フィンガプリンティング
WO2023278672A1 (en) 2021-06-30 2023-01-05 Q-State Biosciences, Inc. Multiplex optical stimulus and readout
JPWO2023210585A1 (cg-RX-API-DMAC7.html) * 2022-04-25 2023-11-02
WO2025084395A1 (ja) * 2023-10-19 2025-04-24 株式会社Jiksak Bioengineering 抗シナプトタグミン２抗体
WO2025089346A1 (ja) * 2023-10-25 2025-05-01 株式会社Jiksak Bioengineering 抗シナプトフィジン抗体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1403645B1 (en) 1998-07-17 2007-09-12 Vertex Pharmaceuticals (San Diego) LLC Detector and screening device for ion channels
US6686193B2 (en) * 2000-07-10 2004-02-03 Vertex Pharmaceuticals, Inc. High throughput method and system for screening candidate compounds for activity against target ion channels
US7615356B2 (en) * 2000-07-10 2009-11-10 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
EP1425065A4 (en) * 2001-07-12 2004-12-15 Merck & Co Inc ELECTRIC FIELD STIMULATION WITH EUKARYONTIC CELLS
US7221981B2 (en) * 2002-03-28 2007-05-22 Northstar Neuroscience, Inc. Electrode geometries for efficient neural stimulation
US20070274923A1 (en) 2005-01-11 2007-11-29 Philippe Brulet Non-invasive real-time in vivo bioluminescence imaging of local Ca2+ dynamics in living organisms

Also Published As

Publication number Publication date
US20120053084A1 (en) 2012-03-01
WO2010027446A4 (en) 2010-08-05
EP2329275A2 (en) 2011-06-08
JP2012501646A (ja) 2012-01-26
US20180136198A1 (en) 2018-05-17
CA2744804A1 (en) 2010-03-11
JP6106225B2 (ja) 2017-03-29
CN102203622A (zh) 2011-09-28
WO2010027446A3 (en) 2010-05-20
AU2009288657A1 (en) 2010-03-11
CA2744804C (en) 2019-02-05
WO2010027446A2 (en) 2010-03-11
JP2016019736A (ja) 2016-02-04
JP5789513B2 (ja) 2015-10-07
AU2016202387A1 (en) 2016-05-05

Similar Documents

Publication Publication Date Title
KR20110073494A (ko) 시냅스 소포 순환 검정 및 시스템
Liu et al. Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy
Yoo et al. Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification
Kohro et al. Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity
Dong et al. Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Yao et al. Analysis of functional neuronal connectivity in the Drosophila brain
JP5645816B2 (ja) 中枢神経細胞の増殖及び分化に係る中核因子を含む医薬組成物
Hirbec et al. Emerging technologies to study glial cells
US20230384333A1 (en) Gpcr screening method to identify non-hallucinogenic compounds
Zapata et al. Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission
JP2013240352A (ja) 発光タンパクによる長期モニタリング方法および解析方法
Cioni et al. Nitric oxide and the neuroendocrine control of the osmotic stress response in teleosts
US20060063202A1 (en) High throughput method and system for screening candidate compounds for activity against epilepsy and other neurological diseases
CN106687588A (zh) 钙指示基因
MX2012003773A (es) Genes. metodos y composiciones relacionadas con la neurogenesis y su modulacion.
US20210161383A1 (en) Chromatic bioluminescence as a cellular level readout system of neural activity
Mikati et al. Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress
WO2023122254A2 (en) Methods to elicit desire to mate and mating behavior
HK1162671A (en) Synaptic vesicle cycling assays and systems
Karki et al. Evolutionarily conserved role of serotonin signaling in regulating actomyosin contractility during morphogenesis
Krämer Characterization of CNP-induced cGMP signaling in the gastrointestinal tract and its role in colonic smooth muscle relaxation
Mikati et al. Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice
Cechová The effects of opioid ligands on their receptors in model cells (eg lymphocytes, neural cells, cell lines)
Hasan Lysosome Dynamics in Models of Frontotemporal Dementia and Alzheimer’s Disease
Aggarwal et al. Check for updates Chapter

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20110404

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
AMND Amendment
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20140829

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20151014

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20160521

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20151014

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

AMND Amendment
PX0901 Re-examination

Patent event code: PX09011S01I

Patent event date: 20160521

Comment text: Decision to Refuse Application

Patent event code: PX09012R01I

Patent event date: 20140829

Comment text: Amendment to Specification, etc.

PX0601 Decision of rejection after re-examination

Comment text: Decision to Refuse Application

Patent event code: PX06014S01D

Patent event date: 20160913

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20160822

Comment text: Decision to Refuse Application

Patent event code: PX06011S01I

Patent event date: 20160521

Comment text: Notification of reason for refusal

Patent event code: PX06013S01I

Patent event date: 20151014

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20140829