AU2009288657A1 - Synaptic vesicle cycling assays and systems - Google Patents
Synaptic vesicle cycling assays and systems Download PDFInfo
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- AU2009288657A1 AU2009288657A1 AU2009288657A AU2009288657A AU2009288657A1 AU 2009288657 A1 AU2009288657 A1 AU 2009288657A1 AU 2009288657 A AU2009288657 A AU 2009288657A AU 2009288657 A AU2009288657 A AU 2009288657A AU 2009288657 A1 AU2009288657 A1 AU 2009288657A1
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- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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| EP2254458A1 (en) * | 2008-02-04 | 2010-12-01 | Bayer HealthCare, LLC | Semiconductor based analyte sensors and methods |
| US9217155B2 (en) | 2008-05-28 | 2015-12-22 | University Of Massachusetts | Isolation of novel AAV'S and uses thereof |
| US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
| CN103168236B (zh) | 2010-08-23 | 2016-01-20 | 哈佛大学管理委员会 | 用于膜电位测定的光遗传学探针 |
| US9207237B2 (en) | 2010-08-23 | 2015-12-08 | President And Fellows Of Harvard College | Systems, methods, and workflows for optogenetics analysis |
| US9488637B2 (en) * | 2011-01-26 | 2016-11-08 | The Curators Of The University Of Missouri | Combination of single-cell electroporation and electrical recording using the same electrode |
| CA2870511C (en) | 2011-04-21 | 2023-08-08 | University Of Massachusetts | Raav-based compositions and methods for treating alpha-1 anti-trypsin deficiencies |
| WO2013078347A2 (en) * | 2011-11-23 | 2013-05-30 | President And Fellows Of Harvard College | Systems and methods for imaging at high spatial and/or temporal precision |
| US9696275B2 (en) | 2012-10-12 | 2017-07-04 | The Curators Of The University Of Missouri | Addressable electrode arrays in multiple fluidic compartments and uses thereof |
| EP2913391B1 (en) * | 2012-10-25 | 2020-07-01 | Hamamatsu Photonics K.K. | Cell observation device, and cell observation method |
| US9778189B2 (en) | 2012-10-25 | 2017-10-03 | Hamamatsu Photonics K.K. | Cell observation device, electrical stimulation device, and cell observation method |
| JP6370544B2 (ja) * | 2013-11-11 | 2018-08-08 | 浜松ホトニクス株式会社 | 細胞観察装置及び細胞観察方法 |
| US10415010B2 (en) | 2014-01-16 | 2019-09-17 | Hamamatsu Photonics K.K. | Cell observation device, electrostimulation device, and cell observation method |
| WO2015127128A2 (en) | 2014-02-19 | 2015-08-27 | University Of Massachusetts | Recombinant aavs having useful transcytosis properties |
| EP4410805A3 (en) | 2014-03-18 | 2024-11-27 | University of Massachusetts | Raav-based compositions and methods for treating amyotrophic lateral sclerosis |
| US9594075B2 (en) | 2014-04-22 | 2017-03-14 | Q-State Biosciences, Inc. | Diagnostic methods for neural disorders |
| EP3134522B1 (en) | 2014-04-25 | 2021-10-06 | University of Massachusetts | Recombinant aav vectors useful for reducing immunity against transgene products |
| US9518103B2 (en) | 2014-06-18 | 2016-12-13 | President And Fellows Of Harvard College | Optogenetic probes for measuring membrane potential |
| SG11201701540PA (en) | 2014-08-28 | 2017-03-30 | Stemonix Inc | Method of fabricating cell arrays and uses thereof |
| WO2016054554A1 (en) | 2014-10-03 | 2016-04-07 | University Of Massachusetts | Heterologous targeting peptide grafted aavs |
| JP6842410B2 (ja) | 2014-10-03 | 2021-03-17 | ユニバーシティ オブ マサチューセッツ | 新規の高効率ライブラリーにより同定されるａａｖベクター |
| RU2738421C2 (ru) | 2014-10-21 | 2020-12-14 | Юниверсити Оф Массачусетс | Варианты рекомбинантных aav и их применения |
| WO2016115333A1 (en) | 2015-01-15 | 2016-07-21 | President And Fellows Of Harvard College | Optical selection of cells |
| EP3256170B1 (en) | 2015-02-13 | 2020-09-23 | University of Massachusetts | Compositions and methods for transient delivery of nucleases |
| US10048275B2 (en) | 2015-03-13 | 2018-08-14 | Q-State Biosciences, Inc. | Cardiotoxicity screening methods |
| CA3019315A1 (en) | 2015-04-23 | 2016-10-27 | University Of Massachusetts | Modulation of aav vector transgene expression |
| US11046955B2 (en) | 2015-04-24 | 2021-06-29 | University Of Massachusetts | Modified AAV constructs and uses thereof |
| US11248212B2 (en) | 2015-06-30 | 2022-02-15 | StemoniX Inc. | Surface energy directed cell self assembly |
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| US11826433B2 (en) | 2016-02-02 | 2023-11-28 | University Of Massachusetts | Method to enhance the efficiency of systemic AAV gene delivery to the central nervous system |
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| EP3225279B1 (en) * | 2016-03-31 | 2023-12-20 | Université de Rennes | Brain tissue stimulation apparatus and computer program |
| US11207426B2 (en) | 2016-04-05 | 2021-12-28 | University Of Massachusetts | Compositions and methods for selective inhibition of grainyhead-like protein expression |
| US11413356B2 (en) | 2016-04-15 | 2022-08-16 | University Of Massachusetts | Methods and compositions for treating metabolic imbalance |
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| US10457940B2 (en) | 2016-09-22 | 2019-10-29 | University Of Massachusetts | AAV treatment of Huntington's disease |
| WO2018071831A1 (en) | 2016-10-13 | 2018-04-19 | University Of Massachusetts | Aav capsid designs |
| WO2018208972A1 (en) | 2017-05-09 | 2018-11-15 | University Of Massachusetts | Methods of treating amyotrophic lateral sclerosis (als) |
| EP3684937A4 (en) | 2017-09-22 | 2021-06-02 | University of Massachusetts | NEW DUAL SOD1 EXPRESSION VECTORS AND RELATED USES |
| CA3096102A1 (en) | 2018-04-13 | 2019-10-17 | University Of Massachusetts | Bicistronic aav vectors encoding hexosaminidase alpha and beta-subunits and uses thereof |
| JP7065433B2 (ja) * | 2018-08-14 | 2022-05-12 | 日本電信電話株式会社 | 電極及びその製造方法、並びに積層体 |
| JP7709201B2 (ja) | 2018-10-05 | 2025-07-16 | ユニバーシティ オブ マサチューセッツ | ＧＭ１ガングリオシドーシスおよびＧＭ２ガングリオシドーシスの処置のためのｒＡＡＶベクター |
| AU2020314729B2 (en) * | 2019-07-16 | 2023-07-06 | Meso Scale Technologies, Llc. | Assay apparatuses, methods and reagents |
| JP2024501849A (ja) * | 2020-12-31 | 2024-01-16 | キュー－ステート バイオサイエンシーズ， インコーポレイテッド | 光学プレートコントローラおよびリーダ |
| EP4271978A4 (en) | 2020-12-31 | 2024-12-18 | Q-State Biosciences, Inc. | MICROSCOPE WITH SPATIAL IMAGING AND BEAM HOMOGENIZER |
| WO2022146981A1 (en) * | 2020-12-31 | 2022-07-07 | Q-State Biosciences, Inc. | Plate imager |
| EP4271994A4 (en) | 2020-12-31 | 2024-11-27 | Q-State Biosciences, Inc. | Calibrating and normalizing imager for optogenetics |
| JP2024516303A (ja) * | 2021-05-04 | 2024-04-12 | キュー－ステート バイオサイエンシーズ， インコーポレイテッド | 薬物フィンガプリンティング |
| WO2023278672A1 (en) | 2021-06-30 | 2023-01-05 | Q-State Biosciences, Inc. | Multiplex optical stimulus and readout |
| JPWO2023210585A1 (cg-RX-API-DMAC7.html) * | 2022-04-25 | 2023-11-02 | ||
| WO2025084395A1 (ja) * | 2023-10-19 | 2025-04-24 | 株式会社Jiksak Bioengineering | 抗シナプトタグミン２抗体 |
| WO2025089346A1 (ja) * | 2023-10-25 | 2025-05-01 | 株式会社Jiksak Bioengineering | 抗シナプトフィジン抗体 |
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| EP1403645B1 (en) | 1998-07-17 | 2007-09-12 | Vertex Pharmaceuticals (San Diego) LLC | Detector and screening device for ion channels |
| US6686193B2 (en) * | 2000-07-10 | 2004-02-03 | Vertex Pharmaceuticals, Inc. | High throughput method and system for screening candidate compounds for activity against target ion channels |
| US7615356B2 (en) * | 2000-07-10 | 2009-11-10 | Vertex Pharmaceuticals (San Diego) Llc | Ion channel assay methods |
| EP1425065A4 (en) * | 2001-07-12 | 2004-12-15 | Merck & Co Inc | ELECTRIC FIELD STIMULATION WITH EUKARYONTIC CELLS |
| US7221981B2 (en) * | 2002-03-28 | 2007-05-22 | Northstar Neuroscience, Inc. | Electrode geometries for efficient neural stimulation |
| US20070274923A1 (en) | 2005-01-11 | 2007-11-29 | Philippe Brulet | Non-invasive real-time in vivo bioluminescence imaging of local Ca2+ dynamics in living organisms |
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| EP2329275A2 (en) | 2011-06-08 |
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| AU2016202387A1 (en) | 2016-05-05 |
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