KR20110052627A - 전립선암과 관련된 시그너처 및 pc결정인자 및 그의 사용 방법 - Google Patents

전립선암과 관련된 시그너처 및 pc결정인자 및 그의 사용 방법 Download PDF

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KR20110052627A
KR20110052627A KR1020117003408A KR20117003408A KR20110052627A KR 20110052627 A KR20110052627 A KR 20110052627A KR 1020117003408 A KR1020117003408 A KR 1020117003408A KR 20117003408 A KR20117003408 A KR 20117003408A KR 20110052627 A KR20110052627 A KR 20110052627A
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pcdeterminants
cancer
tumor
pten
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로날드 데피뇨
지후 딩
린다 친
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다나-파버 캔서 인스티튜트 인크.
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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KR1020117003408A 2008-07-16 2009-07-16 전립선암과 관련된 시그너처 및 pc결정인자 및 그의 사용 방법 Withdrawn KR20110052627A (ko)

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US61/081,286 2008-07-16

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US (3) US20110265197A1 (enExample)
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CN (1) CN102159727A (enExample)
AU (1) AU2009270851A1 (enExample)
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CA (1) CA2730614A1 (enExample)
IL (1) IL210681A0 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014107002A1 (ko) * 2013-01-04 2014-07-10 서울대학교 산학협력단 폐암 진단용 마커

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3081061C (en) 2010-07-27 2023-01-03 Genomic Health, Inc. Method for using expression of klk2 to determine prognosis of prostate cancer
WO2012061510A2 (en) * 2010-11-03 2012-05-10 Merck Sharp & Dohme Corp. Methods of predicting cancer cell response to therapeutic agents
US10260097B2 (en) * 2011-06-02 2019-04-16 Almac Diagnostics Limited Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent
HK1197276A1 (en) * 2011-06-22 2015-01-09 Oncocyte Corporation Methods and compositions for the treatment and diagnosis of bladder cancer
CA2840066A1 (en) 2011-06-27 2013-01-03 Dana-Farber Cancer Institute, Inc. Signatures and determinants associated with prostate cancer progression and methods of use thereof
WO2013031757A1 (ja) * 2011-08-29 2013-03-07 東レ株式会社 膵癌、乳癌、肺癌又は前立腺癌の検出用マーカー及び検査方法
MX351626B (es) 2012-01-31 2017-10-23 Genomic Health Inc Algoritmo de perfil de expresion genica y prueba para determinar la prognosis de cancer de prostata.
WO2013163134A2 (en) * 2012-04-23 2013-10-31 The Trustees Of Columbia University In The City Of New York Biomolecular events in cancer revealed by attractor metagenes
SG11201408651TA (en) 2012-06-27 2015-01-29 Berg Llc Use of markers in the diagnosis and treatment of prostate cancer
US20140011685A1 (en) * 2012-07-03 2014-01-09 Yixin Wang Genomic diagnostics using circulating endothelial cells
AU2013342273A1 (en) * 2012-11-09 2015-05-21 Dana-Farber Cancer Institute, Inc. Metabolic profiling in tissue and serum is indicative of tumor differentiation in prostate cancer
HK1214633A1 (zh) 2012-12-03 2016-07-29 Almac Diagnostics Limited 癌症的分子诊断测试
US20160024592A1 (en) * 2013-03-14 2016-01-28 The Board Of Regents Of The University Of Texas System Single-cell analysis as a sensitive and specific method for early prostate cancer detection
EP2971054A4 (en) 2013-03-14 2017-04-12 Otraces Inc. A method for improving disease diagnosis using measured analytes
CN105861692A (zh) * 2013-06-24 2016-08-17 复旦大学附属肿瘤医院 研究前列腺癌复发和转移的方法
GB201322034D0 (en) 2013-12-12 2014-01-29 Almac Diagnostics Ltd Prostate cancer classification
AU2014375206B2 (en) * 2014-01-03 2021-09-30 Innosign B.V. Assessment of the PI3K cellular signaling pathway activity using mathematical modelling of target gene expression.
EP3100054B1 (en) 2014-01-28 2022-02-23 Quest Diagnostics Investments Incorporated Method and compositions for detecting an adenoma-adenocarcinoma transition in cancer
GB201409479D0 (en) 2014-05-28 2014-07-09 Almac Diagnostics Ltd Molecular diagnostic test for cancer
US9994912B2 (en) 2014-07-03 2018-06-12 Abbott Molecular Inc. Materials and methods for assessing progression of prostate cancer
KR102657306B1 (ko) 2014-12-08 2024-04-12 버그 엘엘씨 전립선암의 진단 및 치료에서 필라민을 포함하는 마커의 용도
CA2996426A1 (en) 2015-10-05 2017-04-13 Cedars-Sinai Medical Center Method of classifying and diagnosing cancer
WO2017079571A1 (en) 2015-11-05 2017-05-11 Arphion Diagnostics Process for the indentication of patients at risk for oscc
US11079745B2 (en) * 2015-11-25 2021-08-03 Lawrence Livermore National Security, Llc Rapid closed-loop control based on machine learning
CA3011988A1 (en) 2016-01-22 2017-07-27 Otraces Inc. Systems and methods for improving disease diagnosis
KR101881874B1 (ko) * 2016-04-29 2018-07-26 한국수력원자력 주식회사 저선량 방사선 조사에 의한 암화 예방 방법
EP3468546A4 (en) 2016-06-09 2020-04-01 Cedars-Sinai Medical Center COMPOSITIONS AND METHODS FOR TREATING CANCER
JP2019532096A (ja) * 2016-08-30 2019-11-07 ベス イスラエル デアコネス メディカル センター インコーポレイティッド 腫瘍抑制因子欠損がんを処置するための組成物および方法
US10487365B2 (en) 2016-09-20 2019-11-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for detecting expression of lnc-FANCI-2 in cervical cells
CA2984267A1 (en) * 2016-11-01 2018-05-01 Medarchon, Inc. Patient handoff device, system and predictive method
US11312998B2 (en) * 2016-11-07 2022-04-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for selecting therapy for a cancer patient
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
WO2019213133A1 (en) * 2018-04-30 2019-11-07 City Of Hope Cancer detection and ablation system and method
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
CN113705585A (zh) * 2018-10-15 2021-11-26 因美纳有限公司 基于神经网络实现的方法和系统
US20220088031A1 (en) * 2019-02-01 2022-03-24 Health Research, Inc. Methods and compositions for treating resistant and recurrent forms of cancer
CA3129228A1 (en) 2019-02-06 2020-08-13 Berg Llc Markers for the diagnosis of biochemical recurrence in prostate cancer
WO2021062261A1 (en) * 2019-09-25 2021-04-01 The Trustees Of Columbia University In The City Of New York Prognostic markers of metastatic cancer
KR102380529B1 (ko) * 2020-04-29 2022-03-31 인제대학교 산학협력단 전이성 전립선 암의 진단 및 예후 예측을 위한 혈중종양세포 기반 바이오 마커 조성물
US12271832B2 (en) * 2021-02-12 2025-04-08 Tempus Ai, Inc. Artificial intelligence engine for directed hypothesis generation and ranking
WO2026078234A1 (en) * 2024-10-10 2026-04-16 Consiglio Nazionale Delle Ricerche Prognostic signature for prostate cancer classification

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2905579T3 (es) * 2003-07-10 2022-04-11 Genomic Health Inc Algoritmo del perfil de expresión y prueba para el pronóstico de la recaída del cáncer de mama
WO2006086345A2 (en) * 2005-02-07 2006-08-17 The Trustees Of Columbia University In The City Of New York Methods to treat or prevent hormone-resistant prostate cancer using sirna specific for protocadherin-pc, or other inhibitors of protocadherin-pc expression or activity
EP2674435A3 (en) * 2006-03-24 2014-04-30 Phenomenome Discoveries Inc. Biomarkers useful for diagnosing prostate cancer, and methods thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014107002A1 (ko) * 2013-01-04 2014-07-10 서울대학교 산학협력단 폐암 진단용 마커
KR101456683B1 (ko) * 2013-01-04 2014-11-06 서울대학교산학협력단 폐암 진단용 마커

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CA2730614A1 (en) 2010-01-21
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