KR20110050541A - 항-ｃｄ５ 항체 - Google Patents

항-ｃｄ５ 항체 Download PDF

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Publication number
KR20110050541A
KR20110050541A KR1020117007230A KR20117007230A KR20110050541A KR 20110050541 A KR20110050541 A KR 20110050541A KR 1020117007230 A KR1020117007230 A KR 1020117007230A KR 20117007230 A KR20117007230 A KR 20117007230A KR 20110050541 A KR20110050541 A KR 20110050541A
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KR
South Korea
Prior art keywords
antibody
ser
thr
tyr
gly
Prior art date
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KR1020117007230A
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English (en)
Korean (ko)
Inventor
죠세핀 엘. 케이. 클리트가드
찰스 피케
미켈 반달 페데르센
클라우스 코에포에드
Original Assignee
심포젠 에이/에스
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Publication date
Application filed by 심포젠 에이/에스 filed Critical 심포젠 에이/에스
Publication of KR20110050541A publication Critical patent/KR20110050541A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020117007230A 2008-08-29 2009-08-28 항-ｃｄ５ 항체 Withdrawn KR20110050541A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200801191 2008-08-29
DKPA200801191 2008-08-29
US9370008P 2008-09-02 2008-09-02
US61/093,700 2008-09-02

Publications (1)

Publication Number Publication Date
KR20110050541A true KR20110050541A (ko) 2011-05-13

Family

ID=40677719

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117007230A Withdrawn KR20110050541A (ko) 2008-08-29 2009-08-28 항-ｃｄ５ 항체

Country Status (15)

Country Link
US (1) US20110250203A1 (enExample)
EP (1) EP2328932A1 (enExample)
JP (1) JP2012500815A (enExample)
KR (1) KR20110050541A (enExample)
CN (1) CN102137873A (enExample)
AU (1) AU2009287164A1 (enExample)
BR (1) BRPI0917148A2 (enExample)
CA (1) CA2735279A1 (enExample)
IL (1) IL209975A0 (enExample)
MX (1) MX2011000970A (enExample)
NZ (1) NZ591153A (enExample)
RU (1) RU2011111640A (enExample)
TW (1) TW201011045A (enExample)
WO (1) WO2010022737A1 (enExample)
ZA (1) ZA201100300B (enExample)

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US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
CN102786595B (zh) * 2012-08-03 2014-04-23 无锡傲锐东源生物科技有限公司 抗cd5蛋白单克隆抗体及其用途
CN107880126B (zh) 2012-12-21 2021-03-30 西雅图基因公司 抗ntb-a抗体及相关组合物和方法
JP6441232B2 (ja) * 2012-12-27 2018-12-19 サノフイＳａｎｏｆｉ 抗ｌａｍｐ１抗体および抗体薬物コンジュゲート、ならびにその使用
HRP20191865T1 (hr) 2013-01-14 2020-01-10 Xencor, Inc. Novi heterodimerni proteini
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US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
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CN116333153A (zh) 2014-11-26 2023-06-27 森科股份有限公司 结合cd3和肿瘤抗原的异二聚体抗体
US20170151281A1 (en) 2015-02-19 2017-06-01 Batu Biologics, Inc. Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
US10786549B2 (en) 2015-04-23 2020-09-29 Baylor College Of Medicine CD5 chimeric antigen receptor for adoptive T cell therapy
US11369663B2 (en) * 2016-06-07 2022-06-28 Washington University Detection of CD5 and methods and compositions for modulating CD5
KR20190020341A (ko) 2016-06-28 2019-02-28 젠코어 인코포레이티드 소마토스타틴 수용체 2에 결합하는 이종이량체 항체
WO2018017864A2 (en) * 2016-07-20 2018-01-25 Oncomed Pharmaceuticals, Inc. Pvrig-binding agents and uses thereof
CN109923126B (zh) * 2016-09-16 2022-06-03 上海复宏汉霖生物技术股份有限公司 抗-pd-1抗体
US20180128545A1 (en) 2016-11-08 2018-05-10 Berry Metal Company Modular furnace cooling wall
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KR20200094181A (ko) 2017-11-29 2020-08-06 마젠타 테라퓨틱스 인코포레이티드 Cd5+ 세포를 고갈시키기 위한 조성물 및 방법
CN112469477A (zh) 2018-04-04 2021-03-09 Xencor股份有限公司 与成纤维细胞活化蛋白结合的异源二聚体抗体
IL316074A (en) * 2018-04-18 2024-12-01 Biomadison Inc Compounds for determining vaccine potency
EP3876977A1 (en) 2018-11-06 2021-09-15 The Regents Of The University Of California Chimeric antigen receptors for phagocytosis
CN113454117B (zh) 2018-12-19 2025-07-04 宾夕法尼亚大学董事会 Cd2/5/7敲除抗-cd2/5/7嵌合抗原受体t细胞针对t细胞淋巴瘤和白血病的用途
KR20210137485A (ko) 2019-04-05 2021-11-17 아카데미아 시니카 시알리다제-내성 당류 및 이의 제조 및 사용 방법
WO2020216947A1 (en) 2019-04-24 2020-10-29 Heidelberg Pharma Research Gmbh Amatoxin antibody-drug conjugates and uses thereof
US11013764B2 (en) 2019-04-30 2021-05-25 Myeloid Therapeutics, Inc. Engineered phagocytic receptor compositions and methods of use thereof
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US10980836B1 (en) 2019-12-11 2021-04-20 Myeloid Therapeutics, Inc. Therapeutic cell compositions and methods of manufacturing and use thereof
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JP2023538108A (ja) * 2020-08-21 2023-09-06 シティ・オブ・ホープ 抗ｃｄ５抗体組成物及びその使用
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US20250179172A1 (en) * 2020-12-17 2025-06-05 Hainan Simcere Zaiming Pharmaceutical Co., Ltd. Cd5 antibody and use thereof
US20240050568A1 (en) * 2021-01-12 2024-02-15 Nanjing IASO Biotechnology Co., Ltd. Fully human single-domain tandem chimeric antigen receptor (car) targeting cd5, and use thereof
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DE4312916C2 (de) * 1993-04-14 1995-03-23 Fresenius Ag Arzneimittel zur Behandlung von Immunreaktionen

Also Published As

Publication number Publication date
CA2735279A1 (en) 2010-03-04
MX2011000970A (es) 2011-03-15
US20110250203A1 (en) 2011-10-13
AU2009287164A1 (en) 2010-03-04
TW201011045A (en) 2010-03-16
ZA201100300B (en) 2012-01-25
NZ591153A (en) 2012-12-21
IL209975A0 (en) 2011-02-28
JP2012500815A (ja) 2012-01-12
WO2010022737A1 (en) 2010-03-04
RU2011111640A (ru) 2012-10-10
EP2328932A1 (en) 2011-06-08
BRPI0917148A2 (pt) 2015-12-01
CN102137873A (zh) 2011-07-27

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PA0105 International application

Patent event date: 20110329

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid