KR20100130226A - 액티빈-유사 수용체 키나제 （ａｌｋ4 또는 ａｌｋ5） 억제제로서의 이미다조-피리딘 유도체 - Google Patents
액티빈-유사 수용체 키나제 （ａｌｋ4 또는 ａｌｋ5） 억제제로서의 이미다조-피리딘 유도체 Download PDFInfo
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- KR20100130226A KR20100130226A KR1020107024212A KR20107024212A KR20100130226A KR 20100130226 A KR20100130226 A KR 20100130226A KR 1020107024212 A KR1020107024212 A KR 1020107024212A KR 20107024212 A KR20107024212 A KR 20107024212A KR 20100130226 A KR20100130226 A KR 20100130226A
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- Prior art keywords
- alkyl
- pyridin
- imidazo
- alkoxy
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Classifications
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| EP08155405 | 2008-04-29 | ||
| EP08155405.7 | 2008-04-29 |
Publications (1)
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| KR20100130226A true KR20100130226A (ko) | 2010-12-10 |
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Family Applications (1)
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| EP (1) | EP2307402B1 (https=) |
| JP (1) | JP5507543B2 (https=) |
| KR (1) | KR20100130226A (https=) |
| CN (1) | CN102015691B (https=) |
| AU (1) | AU2009242145B2 (https=) |
| BR (1) | BRPI0911490A2 (https=) |
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| MX (1) | MX2010011867A (https=) |
| PL (1) | PL2307402T3 (https=) |
| PT (1) | PT2307402E (https=) |
| WO (1) | WO2009133070A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012064043A2 (ko) | 2010-11-08 | 2012-05-18 | 에스케이케미칼 주식회사 | 폴리유산 수지, 이의 제조 방법 및 이를 포함하는 포장용 필름 |
Families Citing this family (24)
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| AU2010344973B2 (en) | 2010-02-05 | 2016-06-16 | Merck Patent Gmbh | Hetaryl-[1,8]naphthyridine derivatives |
| ES2528441T3 (es) | 2010-02-22 | 2015-02-10 | Merck Patent Gmbh | Hetarilaminonaftiridinas |
| US9073918B2 (en) | 2010-05-20 | 2015-07-07 | Takeda Pharmaceutical Company Limited | Pyrazolo[4,3-b]pyridine-7-amine inhibitors of ALK5 |
| US8871744B2 (en) | 2010-07-21 | 2014-10-28 | B & G Partyers, LLC | Compounds and methods for selectively targeting tumor-associated mucins |
| WO2012138223A2 (en) * | 2011-04-05 | 2012-10-11 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Compounds and methods for altering activin receptor-like kinase signalling |
| JP2016510764A (ja) | 2013-03-07 | 2016-04-11 | カリフィア バイオ, インク.Califia Bio, Inc. | 混合系キナーゼ阻害剤および治療法 |
| CN107531697A (zh) * | 2015-04-16 | 2018-01-02 | 默克专利股份公司 | 3‑(1h‑苯并咪唑‑2‑基)‑1h‑吡啶‑2‑酮衍生物 |
| WO2017053657A1 (en) * | 2015-09-23 | 2017-03-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of alk and srpk and methods of use |
| RU2642456C2 (ru) * | 2016-06-29 | 2018-01-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный университет им. П.Г. Демидова" | Способ получения N-арилзамещенных 3H-имидазо[4,5-b]пиридинов |
| EP3492461B1 (en) | 2016-07-29 | 2024-10-23 | Shanghai Yingli Pharmaceutical Co. Ltd. | Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof |
| CN106831770A (zh) * | 2017-03-13 | 2017-06-13 | 牡丹江医学院 | 一种药物组合物及其用于治疗肝硬化的用途 |
| CN110066277B (zh) | 2018-01-24 | 2021-07-23 | 上海璎黎药业有限公司 | 芳香杂环取代烯烃化合物、其制备方法、药物组合物和应用 |
| CN110066276B (zh) | 2018-01-24 | 2020-09-18 | 上海璎黎药业有限公司 | 芳香杂环化合物、其中间体、制备方法、药物组合物和应用 |
| US20200247812A1 (en) * | 2018-07-10 | 2020-08-06 | Integral Biosciences Private Limited | Heterocyclic compounds and methods of use |
| JP7640458B2 (ja) | 2018-10-05 | 2025-03-05 | アンナプルナ バイオ インコーポレイテッド | Ａｐｊ受容体活性に関連する状態を処置するための化合物および組成物 |
| AU2021205893A1 (en) | 2020-01-08 | 2022-06-23 | Synthis Therapeutics, Inc. | ALK5 inhibitor conjugates and uses thereof |
| EP4142769A4 (en) | 2020-04-28 | 2024-05-15 | Acceleron Pharma Inc. | ACTRII PROTEINS AND USE IN THE TREATMENT OF POSTCAPILLARY PULMONARY HYPERTENSION |
| KR20230041003A (ko) | 2020-07-15 | 2023-03-23 | 키에시 파르마슈티시 엣스. 피. 에이. | Alk5 억제제로서 피리도 옥사진 아미노 유도체 |
| ES2982017T3 (es) | 2020-07-15 | 2024-10-14 | Chiesi Farm Spa | Derivados de pirido-oxazina como inhibidores de ALK5 |
| PT4182308T (pt) | 2020-07-15 | 2024-12-04 | Chiesi Farm Spa | Derivados de piridazinil amino como inibidores de alk5 |
| US20240116948A1 (en) | 2020-12-23 | 2024-04-11 | Chiesi Farmaceutici S.P.A. | Pyrido oxazine derivatives as alk5 inhibitors |
| AU2022351219A1 (en) | 2021-09-21 | 2024-05-02 | Chiesi Farmaceutici S.P.A. | Pyridazinyl amino derivatives as alk5 inhibitors |
| US20250270215A1 (en) | 2022-04-27 | 2025-08-28 | Chiesi Farmaceutici S.P.A. | Imidazole derivatives as alk5 inhibitors |
| CN121712526A (zh) | 2023-06-13 | 2026-03-20 | 辛瑟斯治疗股份有限公司 | 抗cd5抗体及其用途 |
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| DK40192D0 (da) * | 1992-03-26 | 1992-03-26 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| GB9921150D0 (en) * | 1999-09-07 | 1999-11-10 | Merck Sharp & Dohme | Therapeutic agents |
| GB0217783D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Compounds |
| WO2005023246A1 (en) * | 2003-09-04 | 2005-03-17 | Aventis Pharmaceuticals Inc. | Substituted indoles as inhibitors of poly (adp-ribose) polymerase (parp) |
| CA2576765C (en) * | 2004-09-03 | 2013-05-28 | Applied Research Systems Ars Holding N.V. | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors |
| BRPI0714409A2 (pt) * | 2006-07-14 | 2013-03-12 | Novartis Ag | derivados de pirimidina como inibidores de alk-5 |
| CN101522682A (zh) * | 2006-10-30 | 2009-09-02 | 诺瓦提斯公司 | 作为抗炎剂的杂环化合物 |
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- 2009-04-27 CA CA2722131A patent/CA2722131A1/en not_active Abandoned
- 2009-04-27 PT PT97381149T patent/PT2307402E/pt unknown
- 2009-04-27 MX MX2010011867A patent/MX2010011867A/es active IP Right Grant
- 2009-04-27 AU AU2009242145A patent/AU2009242145B2/en not_active Ceased
- 2009-04-27 US US12/935,405 patent/US9079897B2/en not_active Expired - Fee Related
- 2009-04-27 KR KR1020107024212A patent/KR20100130226A/ko not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012064043A2 (ko) | 2010-11-08 | 2012-05-18 | 에스케이케미칼 주식회사 | 폴리유산 수지, 이의 제조 방법 및 이를 포함하는 포장용 필름 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2307402A1 (en) | 2011-04-13 |
| US9079897B2 (en) | 2015-07-14 |
| EP2307402B1 (en) | 2012-11-07 |
| ES2399175T3 (es) | 2013-03-26 |
| JP5507543B2 (ja) | 2014-05-28 |
| AU2009242145B2 (en) | 2012-07-05 |
| WO2009133070A1 (en) | 2009-11-05 |
| CN102015691B (zh) | 2014-01-08 |
| AU2009242145A1 (en) | 2009-11-05 |
| PT2307402E (pt) | 2013-02-15 |
| EA201001687A1 (ru) | 2011-06-30 |
| CN102015691A (zh) | 2011-04-13 |
| BRPI0911490A2 (pt) | 2016-01-05 |
| MX2010011867A (es) | 2010-11-26 |
| JP2011518856A (ja) | 2011-06-30 |
| US20110060004A1 (en) | 2011-03-10 |
| PL2307402T3 (pl) | 2013-05-31 |
| CA2722131A1 (en) | 2009-11-05 |
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