AU2009242145B2 - Imidazo-pyridine derivatives as activin-like receptor kinase (ALK4 or ALK5) inhibitors - Google Patents

Imidazo-pyridine derivatives as activin-like receptor kinase (ALK4 or ALK5) inhibitors Download PDF

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Publication number
AU2009242145B2
AU2009242145B2 AU2009242145A AU2009242145A AU2009242145B2 AU 2009242145 B2 AU2009242145 B2 AU 2009242145B2 AU 2009242145 A AU2009242145 A AU 2009242145A AU 2009242145 A AU2009242145 A AU 2009242145A AU 2009242145 B2 AU2009242145 B2 AU 2009242145B2
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Prior art keywords
alkyl
pyridin
alkoxy
cyclohexanol
cycloalkyl
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AU2009242145A
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AU2009242145A1 (en
Inventor
Catherine Leblanc
Cathy Ritchie
Duncan Shaw
Nikolaus Johannes Stiefl
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P9/08—Vasodilators for multiple indications
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
AU2009242145A 2008-04-29 2009-04-27 Imidazo-pyridine derivatives as activin-like receptor kinase (ALK4 or ALK5) inhibitors Ceased AU2009242145B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08155405 2008-04-29
EP08155405.7 2008-04-29
PCT/EP2009/055066 WO2009133070A1 (en) 2008-04-29 2009-04-27 Imidazo-pyridine derivatives as activin-like receptor kinase (alk4 or alk5) inhibitors

Publications (2)

Publication Number Publication Date
AU2009242145A1 AU2009242145A1 (en) 2009-11-05
AU2009242145B2 true AU2009242145B2 (en) 2012-07-05

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AU2009242145A Ceased AU2009242145B2 (en) 2008-04-29 2009-04-27 Imidazo-pyridine derivatives as activin-like receptor kinase (ALK4 or ALK5) inhibitors

Country Status (14)

Country Link
US (1) US9079897B2 (https=)
EP (1) EP2307402B1 (https=)
JP (1) JP5507543B2 (https=)
KR (1) KR20100130226A (https=)
CN (1) CN102015691B (https=)
AU (1) AU2009242145B2 (https=)
BR (1) BRPI0911490A2 (https=)
CA (1) CA2722131A1 (https=)
EA (1) EA201001687A1 (https=)
ES (1) ES2399175T3 (https=)
MX (1) MX2010011867A (https=)
PL (1) PL2307402T3 (https=)
PT (1) PT2307402E (https=)
WO (1) WO2009133070A1 (https=)

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BR112012018954A2 (pt) 2010-02-05 2016-04-12 Merck Patent Gmbh derivados de hetaril-[1,8]naftiridina
SG183233A1 (en) 2010-02-22 2012-09-27 Merck Patent Gmbh Hetarylaminonaphthyridines
US9073918B2 (en) 2010-05-20 2015-07-07 Takeda Pharmaceutical Company Limited Pyrazolo[4,3-b]pyridine-7-amine inhibitors of ALK5
US8871744B2 (en) 2010-07-21 2014-10-28 B & G Partyers, LLC Compounds and methods for selectively targeting tumor-associated mucins
WO2012064043A2 (ko) 2010-11-08 2012-05-18 에스케이케미칼 주식회사 폴리유산 수지, 이의 제조 방법 및 이를 포함하는 포장용 필름
AU2012240656A1 (en) * 2011-04-05 2013-10-24 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Compounds and methods for altering activin receptor-like kinase signalling
JP2016510764A (ja) 2013-03-07 2016-04-11 カリフィア バイオ, インク.Califia Bio, Inc. 混合系キナーゼ阻害剤および治療法
US10179777B2 (en) 2015-04-16 2019-01-15 Merck Patent Gmbh 3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one derivatives
US10508082B2 (en) * 2015-09-23 2019-12-17 Dana-Farber Cancer Institute, Inc. Substituted 6,11-dihydro-5H-benzo[b]carbazoles as inhibitors of ALK and SRPK
RU2642456C2 (ru) * 2016-06-29 2018-01-25 Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный университет им. П.Г. Демидова" Способ получения N-арилзамещенных 3H-имидазо[4,5-b]пиридинов
JP7007359B2 (ja) 2016-07-29 2022-01-24 シャンハイ インリ ファーマシューティカル カンパニー リミティド 窒素含有芳香族複素環式化合物、その製造方法、薬物組成物および使用
CN106831770A (zh) * 2017-03-13 2017-06-13 牡丹江医学院 一种药物组合物及其用于治疗肝硬化的用途
CN110066277B (zh) 2018-01-24 2021-07-23 上海璎黎药业有限公司 芳香杂环取代烯烃化合物、其制备方法、药物组合物和应用
CN110066276B (zh) 2018-01-24 2020-09-18 上海璎黎药业有限公司 芳香杂环化合物、其中间体、制备方法、药物组合物和应用
US20200247812A1 (en) * 2018-07-10 2020-08-06 Integral Biosciences Private Limited Heterocyclic compounds and methods of use
MX2021003904A (es) * 2018-10-05 2021-10-26 Annapurna Bio Inc Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor apj.
JP2023509760A (ja) 2020-01-08 2023-03-09 シンシス セラピューティクス，インコーポレイテッド Ａｌｋ５阻害剤複合体およびその使用
US20230174620A1 (en) 2020-04-28 2023-06-08 Acceleron Pharma Inc. Actrii proteins and use in treating post-capillary pulmonary hypertension
EP4182308B1 (en) 2020-07-15 2024-09-04 Chiesi Farmaceutici S.p.A. Pyridazinyl amino derivatives as alk5 inhibitors
EP4182323B1 (en) 2020-07-15 2024-04-24 Chiesi Farmaceutici S.p.A. Pyrido oxazine amino derivatives as alk5 inhibitors
ES2982017T3 (es) 2020-07-15 2024-10-14 Chiesi Farm Spa Derivados de pirido-oxazina como inhibidores de ALK5
EP4267584A1 (en) 2020-12-23 2023-11-01 Chiesi Farmaceutici S.p.A. Pyrido oxazine derivatives as alk5 inhibitors
US20250011299A1 (en) 2021-09-21 2025-01-09 Chiesi Farmaceutici S.P.A. Pyridazinyl amino derivatives as alk5 inhibitors
EP4514802A1 (en) 2022-04-27 2025-03-05 Chiesi Farmaceutici S.p.A. Imidazole derivatives as alk5 inhibitors
CN121712526A (zh) 2023-06-13 2026-03-20 辛瑟斯治疗股份有限公司 抗cd5抗体及其用途

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EP0563001A1 (en) * 1992-03-26 1993-09-29 Neurosearch A/S Imidazole compounds, their preparation and use
WO2001018000A1 (en) * 1999-09-07 2001-03-15 Merck Sharp & Dohme Limited Imidazo-pyridine derivatives as ligands for gaba receptors

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WO2005023246A1 (en) * 2003-09-04 2005-03-17 Aventis Pharmaceuticals Inc. Substituted indoles as inhibitors of poly (adp-ribose) polymerase (parp)
CN101052640B (zh) * 2004-09-03 2011-05-11 默克雪兰诺有限公司 吡啶亚甲基唑烷酮类及其作为磷酸肌醇抑制剂的用途
PL2044056T3 (pl) * 2006-07-14 2013-01-31 Novartis Ag Pochodne pirymidyny jako inhibitory ALK-5
JP2010508315A (ja) * 2006-10-30 2010-03-18 ノバルティス アーゲー 抗炎症剤としてのヘテロ環式化合物

Patent Citations (2)

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EP0563001A1 (en) * 1992-03-26 1993-09-29 Neurosearch A/S Imidazole compounds, their preparation and use
WO2001018000A1 (en) * 1999-09-07 2001-03-15 Merck Sharp & Dohme Limited Imidazo-pyridine derivatives as ligands for gaba receptors

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JP2011518856A (ja) 2011-06-30
US20110060004A1 (en) 2011-03-10
JP5507543B2 (ja) 2014-05-28
CA2722131A1 (en) 2009-11-05
KR20100130226A (ko) 2010-12-10
AU2009242145A1 (en) 2009-11-05
PT2307402E (pt) 2013-02-15
ES2399175T3 (es) 2013-03-26
MX2010011867A (es) 2010-11-26
US9079897B2 (en) 2015-07-14
EP2307402B1 (en) 2012-11-07
BRPI0911490A2 (pt) 2016-01-05
CN102015691A (zh) 2011-04-13
EA201001687A1 (ru) 2011-06-30
WO2009133070A1 (en) 2009-11-05
EP2307402A1 (en) 2011-04-13
CN102015691B (zh) 2014-01-08
PL2307402T3 (pl) 2013-05-31

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