CN102015691B - 作为活化素样受体激酶(alk4或alk5)抑制剂的咪唑并吡啶衍生物 - Google Patents

作为活化素样受体激酶(alk4或alk5)抑制剂的咪唑并吡啶衍生物 Download PDF

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CN102015691B
CN102015691B CN200980115503.0A CN200980115503A CN102015691B CN 102015691 B CN102015691 B CN 102015691B CN 200980115503 A CN200980115503 A CN 200980115503A CN 102015691 B CN102015691 B CN 102015691B
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pyridine
pyridin
imidazo
base
compound
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CN102015691A (zh
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C·勒布朗
C·里奇
D·肖
N·J·施蒂夫尔
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
CN200980115503.0A 2008-04-29 2009-04-27 作为活化素样受体激酶(alk4或alk5)抑制剂的咪唑并吡啶衍生物 Expired - Fee Related CN102015691B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08155405 2008-04-29
EP08155405.7 2008-04-29
PCT/EP2009/055066 WO2009133070A1 (en) 2008-04-29 2009-04-27 Imidazo-pyridine derivatives as activin-like receptor kinase (alk4 or alk5) inhibitors

Publications (2)

Publication Number Publication Date
CN102015691A CN102015691A (zh) 2011-04-13
CN102015691B true CN102015691B (zh) 2014-01-08

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CN200980115503.0A Expired - Fee Related CN102015691B (zh) 2008-04-29 2009-04-27 作为活化素样受体激酶(alk4或alk5)抑制剂的咪唑并吡啶衍生物

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Country Link
US (1) US9079897B2 (https=)
EP (1) EP2307402B1 (https=)
JP (1) JP5507543B2 (https=)
KR (1) KR20100130226A (https=)
CN (1) CN102015691B (https=)
AU (1) AU2009242145B2 (https=)
BR (1) BRPI0911490A2 (https=)
CA (1) CA2722131A1 (https=)
EA (1) EA201001687A1 (https=)
ES (1) ES2399175T3 (https=)
MX (1) MX2010011867A (https=)
PL (1) PL2307402T3 (https=)
PT (1) PT2307402E (https=)
WO (1) WO2009133070A1 (https=)

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US9073918B2 (en) 2010-05-20 2015-07-07 Takeda Pharmaceutical Company Limited Pyrazolo[4,3-b]pyridine-7-amine inhibitors of ALK5
US8871744B2 (en) 2010-07-21 2014-10-28 B & G Partyers, LLC Compounds and methods for selectively targeting tumor-associated mucins
CN103328535B (zh) 2010-11-08 2016-01-20 Sk化学株式会社 聚乳酸树脂、其制备方法以及包含所述聚乳酸树脂的包装膜
WO2012138223A2 (en) * 2011-04-05 2012-10-11 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Compounds and methods for altering activin receptor-like kinase signalling
JP2016510764A (ja) 2013-03-07 2016-04-11 カリフィア バイオ, インク.Califia Bio, Inc. 混合系キナーゼ阻害剤および治療法
CN107531697A (zh) * 2015-04-16 2018-01-02 默克专利股份公司 3‑(1h‑苯并咪唑‑2‑基)‑1h‑吡啶‑2‑酮衍生物
WO2017053657A1 (en) * 2015-09-23 2017-03-30 Dana-Farber Cancer Institute, Inc. Inhibitors of alk and srpk and methods of use
RU2642456C2 (ru) * 2016-06-29 2018-01-25 Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный университет им. П.Г. Демидова" Способ получения N-арилзамещенных 3H-имидазо[4,5-b]пиридинов
EP3492461B1 (en) 2016-07-29 2024-10-23 Shanghai Yingli Pharmaceutical Co. Ltd. Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof
CN106831770A (zh) * 2017-03-13 2017-06-13 牡丹江医学院 一种药物组合物及其用于治疗肝硬化的用途
CN110066277B (zh) 2018-01-24 2021-07-23 上海璎黎药业有限公司 芳香杂环取代烯烃化合物、其制备方法、药物组合物和应用
CN110066276B (zh) 2018-01-24 2020-09-18 上海璎黎药业有限公司 芳香杂环化合物、其中间体、制备方法、药物组合物和应用
US20200247812A1 (en) * 2018-07-10 2020-08-06 Integral Biosciences Private Limited Heterocyclic compounds and methods of use
JP7640458B2 (ja) 2018-10-05 2025-03-05 アンナプルナ バイオ インコーポレイテッド Ａｐｊ受容体活性に関連する状態を処置するための化合物および組成物
AU2021205893A1 (en) 2020-01-08 2022-06-23 Synthis Therapeutics, Inc. ALK5 inhibitor conjugates and uses thereof
EP4142769A4 (en) 2020-04-28 2024-05-15 Acceleron Pharma Inc. ACTRII PROTEINS AND USE IN THE TREATMENT OF POSTCAPILLARY PULMONARY HYPERTENSION
KR20230041003A (ko) 2020-07-15 2023-03-23 키에시 파르마슈티시 엣스. 피. 에이. Alk5 억제제로서 피리도 옥사진 아미노 유도체
ES2982017T3 (es) 2020-07-15 2024-10-14 Chiesi Farm Spa Derivados de pirido-oxazina como inhibidores de ALK5
PT4182308T (pt) 2020-07-15 2024-12-04 Chiesi Farm Spa Derivados de piridazinil amino como inibidores de alk5
US20240116948A1 (en) 2020-12-23 2024-04-11 Chiesi Farmaceutici S.P.A. Pyrido oxazine derivatives as alk5 inhibitors
AU2022351219A1 (en) 2021-09-21 2024-05-02 Chiesi Farmaceutici S.P.A. Pyridazinyl amino derivatives as alk5 inhibitors
US20250270215A1 (en) 2022-04-27 2025-08-28 Chiesi Farmaceutici S.P.A. Imidazole derivatives as alk5 inhibitors
CN121712526A (zh) 2023-06-13 2026-03-20 辛瑟斯治疗股份有限公司 抗cd5抗体及其用途

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WO2001018000A1 (en) * 1999-09-07 2001-03-15 Merck Sharp & Dohme Limited Imidazo-pyridine derivatives as ligands for gaba receptors
WO2004013138A2 (en) * 2002-07-31 2004-02-12 Smithkline Beecham Corporation Imidazo`1,2-a!pyridines
WO2008006583A1 (en) * 2006-07-14 2008-01-17 Novartis Ag Pyrimidine derivatives as alk-5 inhibitors

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EP0563001A1 (en) * 1992-03-26 1993-09-29 Neurosearch A/S Imidazole compounds, their preparation and use
WO2001018000A1 (en) * 1999-09-07 2001-03-15 Merck Sharp & Dohme Limited Imidazo-pyridine derivatives as ligands for gaba receptors
WO2004013138A2 (en) * 2002-07-31 2004-02-12 Smithkline Beecham Corporation Imidazo`1,2-a!pyridines
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Synthesis and biological evaluation of novel 2,4,5-triaryl-1H-pyrazol-3(2H)-ones as inhibitors of ALK5;Xing Zhou Li, et al.;《Chinses Chemical letters 》;20081231;第19卷;第379-382页 *

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EP2307402A1 (en) 2011-04-13
US9079897B2 (en) 2015-07-14
EP2307402B1 (en) 2012-11-07
ES2399175T3 (es) 2013-03-26
JP5507543B2 (ja) 2014-05-28
AU2009242145B2 (en) 2012-07-05
WO2009133070A1 (en) 2009-11-05
AU2009242145A1 (en) 2009-11-05
PT2307402E (pt) 2013-02-15
EA201001687A1 (ru) 2011-06-30
CN102015691A (zh) 2011-04-13
BRPI0911490A2 (pt) 2016-01-05
MX2010011867A (es) 2010-11-26
JP2011518856A (ja) 2011-06-30
US20110060004A1 (en) 2011-03-10
KR20100130226A (ko) 2010-12-10
PL2307402T3 (pl) 2013-05-31
CA2722131A1 (en) 2009-11-05

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