KR20100031620A - 암 치료용의 신규의 트리아젠 화합물 - Google Patents

암 치료용의 신규의 트리아젠 화합물 Download PDF

Info

Publication number
KR20100031620A
KR20100031620A KR1020107001039A KR20107001039A KR20100031620A KR 20100031620 A KR20100031620 A KR 20100031620A KR 1020107001039 A KR1020107001039 A KR 1020107001039A KR 20107001039 A KR20107001039 A KR 20107001039A KR 20100031620 A KR20100031620 A KR 20100031620A
Authority
KR
South Korea
Prior art keywords
group
compound
optionally substituted
formula
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020107001039A
Other languages
English (en)
Korean (ko)
Inventor
루돌프 라이터
요헨 칼베
하인즈 푀르스터
Original Assignee
트린 파마 게엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 트린 파마 게엠베하 filed Critical 트린 파마 게엠베하
Publication of KR20100031620A publication Critical patent/KR20100031620A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/22—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond containing chains of three or more nitrogen atoms with one or more nitrogen-to-nitrogen double bonds
    • C07C245/24—Chains of only three nitrogen atoms, e.g. diazoamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • C07C309/15—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton the nitrogen atom of at least one of the amino groups being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020107001039A 2007-07-04 2008-07-03 암 치료용의 신규의 트리아젠 화합물 Withdrawn KR20100031620A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07111716 2007-07-04
EP07111716.2 2007-07-04

Publications (1)

Publication Number Publication Date
KR20100031620A true KR20100031620A (ko) 2010-03-23

Family

ID=38606533

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107001039A Withdrawn KR20100031620A (ko) 2007-07-04 2008-07-03 암 치료용의 신규의 트리아젠 화합물

Country Status (13)

Country Link
US (2) US8034797B2 (https=)
EP (1) EP2167459A1 (https=)
JP (1) JP2010531855A (https=)
KR (1) KR20100031620A (https=)
CN (2) CN102424657A (https=)
AU (1) AU2008270269B2 (https=)
BR (2) BRPI0823332A2 (https=)
CA (1) CA2691178A1 (https=)
EA (1) EA201000141A1 (https=)
MX (1) MX2010000223A (https=)
NZ (1) NZ582346A (https=)
TW (1) TW200908986A (https=)
WO (1) WO2009004060A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140011383A (ko) * 2011-03-16 2014-01-28 크리에이티브 테라퓨틱스 게엠베하 치환된 디페닐 유도체
WO2012130850A1 (de) 2011-03-31 2012-10-04 Bayer Pharma Aktiengesellschaft Gewebetargeting mit onkoziden verbrückten diphenylderivaten zur selektiven behandlung von sexualorgantumoren
EP2557075A1 (de) 2011-08-09 2013-02-13 Trin Therapeutics GmbH Neue Triazenverbindungen zur Behandlung von Krebs
RU2014116229A (ru) 2011-09-23 2015-10-27 Даблхил Гмбх Новые соединения изоцианата и изотиоцианата для лечения злокачественных новообразований
CN105566153B (zh) * 2014-10-14 2019-05-31 中国医学科学院药物研究所 偶氮苯衍生物及其制法和药物组合物与用途
CN109776526A (zh) * 2019-01-23 2019-05-21 西南医科大学 稠环三唑-(磺酰基)三氮烯类衍生物及其合成方法和用途
DE102020125641A1 (de) 2020-09-25 2022-03-31 Creative Therapeutics Gmbh Wirkstoffe und Arzneimittel für die Therapie von Viruserkrankungen, insbesondere Corona-Infektionen, insbesondere COVID-19

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1793115A1 (de) * 1968-08-03 1972-02-03 Bayer Ag Neue Triazenderivate
BE789138A (fr) * 1971-09-24 1973-03-22 Bayer Ag Nouveaux derives triazeniques, leur procede de preparation et medicament les contenant
DE10324496A1 (de) * 2003-05-30 2004-12-16 Bayer Healthcare Ag Targetorientierte Chemotherapie von Tumoren der Sexualorgane

Also Published As

Publication number Publication date
US8034797B2 (en) 2011-10-11
CA2691178A1 (en) 2009-01-08
NZ582346A (en) 2012-04-27
JP2010531855A (ja) 2010-09-30
AU2008270269B2 (en) 2013-04-04
EP2167459A1 (de) 2010-03-31
CN102424657A (zh) 2012-04-25
AU2008270269A2 (en) 2012-04-12
BRPI0823332A2 (pt) 2013-07-30
US20100234327A1 (en) 2010-09-16
EA201000141A1 (ru) 2010-06-30
MX2010000223A (es) 2010-04-30
AU2008270269A1 (en) 2009-01-08
TW200908986A (en) 2009-03-01
US8426390B2 (en) 2013-04-23
CN101796020A (zh) 2010-08-04
WO2009004060A1 (de) 2009-01-08
BRPI0814614A2 (pt) 2011-11-29
US20120028927A1 (en) 2012-02-02

Similar Documents

Publication Publication Date Title
US8426390B2 (en) Triazene compounds for the treatment of cancer
TW513398B (en) Novel derivatives of benzenesulfonic acids
KR100572494B1 (ko) 설포닐아미노카복실산 및 이의 제조방법
CN108314663A (zh) 芴、蒽、呫吨、二苯并环庚酮和吖啶的衍生物及其用途
JP2010077153A (ja) 製薬学的性質を有する新規なアミノジカルボン酸誘導体
KR20040091676A (ko) 증식성 질병 치료용 아미노-치환（ｅ）-2,6-디알콕시스티릴 4-치환-벤질설폰
CN103951615B (zh) 烷基胺衍生物
JP2003528825A (ja) ８ａ位で置換された８，８ａ−ジヒドロ−インデノ［１，２−ｄ］チアゾール誘導体、その製造方法及び医薬、例えば食欲抑制薬としてのその使用
JP2003531117A (ja) ２位にスルホンアミド又はスルホノ置換基を有する８，８ａ−ジヒドロインデノ［１，２−ｄ］チアゾール誘導体、その製造方法及び医薬としてのその使用
TWI762634B (zh) 胺基-芳基-苯甲醯胺化合物及其使用方法
EP0484437A4 (en) Renal-selective prodrugs for the treatment of hypertension
EP2445872A1 (en) Cathepsin cysteine protease inhibitors for the treatment of various diseases
HK1146481A (en) Novel triazine compounds for treatment of cancer
JP2011195516A (ja) 制がん剤
US8987316B2 (en) Isocyanate and isothiocyanate compounds for cancer treatment
US20230391753A1 (en) Thiobenzimidazole derivative or pharmaceutically acceptable salt thereof and use thereof
EP4506346A1 (en) Thiobenzimidazole derivative or pharmaceutically acceptable salt thereof, and use thereof
PT96710A (pt) Processo para a preparacao de novos compostos de imidazol, de composicoes farmaceuticas que os contem e de compostos intermedios usados na sua preparacao
WO1992001667A1 (en) Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension
PL216955B1 (pl) Sole pochodnych cystein i sposób wytwarzania soli pochodnych cystein
MXPA98003661A (en) Acids sulfonilaminocarboxili

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20100115

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 20111024

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid