KR20100015750A - 가용성 ｉｌ-17ｒａ/ｒｃ 융합 단백질 및 관련방법 - Google Patents
가용성 ｉｌ-17ｒａ/ｒｃ 융합 단백질 및 관련방법 Download PDFInfo
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- KR20100015750A KR20100015750A KR1020097021934A KR20097021934A KR20100015750A KR 20100015750 A KR20100015750 A KR 20100015750A KR 1020097021934 A KR1020097021934 A KR 1020097021934A KR 20097021934 A KR20097021934 A KR 20097021934A KR 20100015750 A KR20100015750 A KR 20100015750A
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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| US11/691,000 US20070249533A1 (en) | 2005-09-28 | 2007-03-26 | Il-17a and il-17f antagonists and methods of using the same |
| US90855407P | 2007-03-28 | 2007-03-28 | |
| US60/908,554 | 2007-03-28 | ||
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Cited By (1)
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| WO2024196099A1 (ko) * | 2023-03-17 | 2024-09-26 | 주식회사 큐로젠 | 자가면역질환 치료용 신규 융합단백질 |
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| CN101001871A (zh) * | 2004-06-10 | 2007-07-18 | 津莫吉尼蒂克斯公司 | 可溶性ZcytoR14、抗ZcytoR14抗体和结合伴侣以及在炎症中的使用方法 |
| US7833527B2 (en) | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
| CA2679588A1 (en) | 2007-03-26 | 2008-10-02 | Zymogenetics, Inc. | Soluble il-17ra/rc fusion proteins and related methods |
| SG190626A1 (en) | 2008-05-05 | 2013-06-28 | Novimmune Sa | Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof |
| WO2010081091A2 (en) * | 2009-01-09 | 2010-07-15 | Schepens Eye Research Institute | Therapeutic compositions for treatment of corneal disorders |
| US8911722B2 (en) | 2009-09-14 | 2014-12-16 | The Regents Of The University Of Colorado, A Body Corporate | Modulation of yeast-based immunotherapy products and responses |
| AU2010303166A1 (en) | 2009-10-10 | 2012-05-24 | Eleven Biotherapeutics, Inc. | IL-17 family cytokine compositions and uses |
| TW201117824A (en) * | 2009-10-12 | 2011-06-01 | Amgen Inc | Use of IL-17 receptor a antigen binding proteins |
| EA201891433A3 (ru) | 2010-01-15 | 2019-02-28 | Кирин-Эмджен, Инк. | Состав антитела и терапевтические режимы |
| US20130011413A1 (en) * | 2010-02-03 | 2013-01-10 | The University Of Tokyo | Method and Pharmaceutical Composition for Treatment of Intestinal Disease |
| EP2569335B1 (en) * | 2010-05-14 | 2018-08-22 | Orega Biotech | Methods of treating and/or preventing cell proliferation disorders with il-17 antagonists |
| EP2571901B1 (en) | 2010-05-20 | 2019-01-02 | Ablynx N.V. | Biological materials related to her3 |
| EP2670426B1 (en) | 2011-01-31 | 2017-05-10 | The General Hospital Corporation | Multimodal trail molecules and uses in cellular therapies |
| SI2697257T1 (sl) * | 2011-04-13 | 2017-02-28 | Bristol-Myers Squibb Company | FC fuzijski proteini, ki vsebujejo nove linkerje ali razmestitve |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| CN102688503A (zh) * | 2012-06-20 | 2012-09-26 | 中国农业大学 | 一种促进狐狸增重的药物组合物 |
| CN102688504A (zh) * | 2012-06-20 | 2012-09-26 | 中国农业大学 | 一种促进水貂增重的药物组合物 |
| US9862932B2 (en) | 2012-07-24 | 2018-01-09 | The General Hospital Corporation | Oncolytic virus therapy for resistant tumors |
| US9605074B2 (en) | 2012-08-30 | 2017-03-28 | The General Hospital Corporation | Multifunctional nanobodies for treating cancer |
| DK2922962T3 (en) * | 2012-11-20 | 2017-03-27 | Novartis Ag | Optimized expression cassette for expressing a high yield polypeptide |
| US20160303174A1 (en) | 2013-12-11 | 2016-10-20 | The General Hospital Corporation | Stem cell delivered oncolytic herpes simplex virus and methods for treating brain tumors |
| CN107857818A (zh) * | 2017-08-07 | 2018-03-30 | 上海科新生物技术股份有限公司 | 一种针对IL‑17和TNF‑α的双特异性融合蛋白 |
| WO2019216422A1 (ja) * | 2018-05-10 | 2019-11-14 | 学校法人東京理科大学 | 制御性Ｔ細胞増加剤、クロストリジウム・クラスターＸＩＶａ菌の増殖促進剤、及び炎症性又はアレルギー性の疾患又は症状の予防、治療、又は改善のための組成物 |
| CN116751277A (zh) * | 2023-01-10 | 2023-09-15 | 武汉爱博泰克生物科技有限公司 | 利用毕赤酵母表达活性重组人il-17a蛋白的方法 |
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| US5684032A (en) | 1994-12-13 | 1997-11-04 | Smithkline Beecham Corporation | Compounds |
| MX9707021A (es) | 1995-03-23 | 1997-11-29 | Immunex Corp | Receptor de il-7. |
| US5945511A (en) | 1997-02-20 | 1999-08-31 | Zymogenetics, Inc. | Class II cytokine receptor |
| US20030100051A1 (en) | 1998-05-12 | 2003-05-29 | Ruben Steven M. | 97 human secreted proteins |
| US20020177188A1 (en) | 1998-05-15 | 2002-11-28 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| US6569645B2 (en) | 1999-05-14 | 2003-05-27 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| US6579520B2 (en) | 1998-05-15 | 2003-06-17 | Genentech, Inc. | IL-17 related mammalian cytokine polypeptides (IL-17E) |
| WO1998049307A1 (en) | 1997-05-01 | 1998-11-05 | Zymogenetics, Inc. | Mammalian cytokine-like receptor |
| US5965704A (en) | 1997-08-05 | 1999-10-12 | Zymogenetics, Inc. | Class two cytokine receptor-11 |
| DE69841140D1 (de) | 1997-09-17 | 2009-10-22 | Human Genome Sciences Inc | Interleukin-17 rezeptor-ähnliches protein |
| US7160985B2 (en) | 1997-10-29 | 2007-01-09 | Genentech, Inc. | Pro180 polypeptide |
| US20030040471A1 (en) | 1998-04-29 | 2003-02-27 | Watson James D. | Compositions isolated from skin cells and methods for their use |
| US7247442B1 (en) | 1998-05-12 | 2007-07-24 | Human Genome Sciences, Inc. | Antibodies to HHPEN62 polypeptide |
| US20020182673A1 (en) | 1998-05-15 | 2002-12-05 | Genentech, Inc. | IL-17 homologous polypedies and therapeutic uses thereof |
| JP3577586B2 (ja) | 1998-05-15 | 2004-10-13 | ジェネンテック・インコーポレーテッド | Ｉｌ−１７相同的ポリペプチドとその治療用途 |
| US7339033B2 (en) | 1998-06-26 | 2008-03-04 | Genentech, Inc. | Pro1481 |
| US7507404B2 (en) | 1999-03-08 | 2009-03-24 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US7232889B2 (en) | 1999-03-08 | 2007-06-19 | Genentech, Inc. | PRO300 antibodies |
| US20030199041A1 (en) | 1999-07-07 | 2003-10-23 | Presnell Scott R. | Interleukin-17 receptor homologue |
| DK1190056T3 (da) | 1999-07-07 | 2007-07-30 | Zymogenetics Inc | Human cytokin receptor |
| ATE519847T1 (de) | 1999-12-23 | 2011-08-15 | Genentech Inc | Il-17-homologe polypeptide und ihre therapeutische verwendung |
| US20040048249A1 (en) | 2000-01-21 | 2004-03-11 | Tang Y. Tom | Novel nucleic acids and secreted polypeptides |
| CA2399943A1 (en) | 2000-03-08 | 2001-09-13 | Human Genome Sciences, Inc. | Immune system-related polynucleotides, polypeptides, and antibodies |
| US20030203451A1 (en) * | 2000-08-24 | 2003-10-30 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| US20040197306A1 (en) * | 2000-05-24 | 2004-10-07 | Gorman Daniel M. | Mammalian receptor proteins; related reagents and methods |
| US20030092881A1 (en) | 2000-05-24 | 2003-05-15 | Gorman Daniel M. | Mammalian receptor proteins; related reagents and methods |
| WO2002004519A2 (en) | 2000-07-06 | 2002-01-17 | Zymogenetics, Inc. | Murine cytokine receptor |
| US20040171109A1 (en) | 2000-11-10 | 2004-09-02 | Dominik Haudenschild | IL-17 receptor-like protein, uses thereof, and modulation of catabolic activity of il-17 cytokines on bone and cartilage |
| US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| US20030073623A1 (en) | 2001-07-30 | 2003-04-17 | Drmanac Radoje T. | Novel nucleic acid sequences obtained from various cDNA libraries |
| US6681210B2 (en) | 2001-09-04 | 2004-01-20 | Andrew Jeffrey Kelly | Modular service payroll system |
| US20040097447A1 (en) | 2002-11-16 | 2004-05-20 | Isis Pharmaceuticals Inc. | Modulation of interleukin 22 receptor expression |
| EP2784084B2 (en) * | 2003-07-08 | 2023-10-04 | Novartis Pharma AG | Antagonist antibodies to IL-17A/F heterologous polypeptides |
| CN101001871A (zh) | 2004-06-10 | 2007-07-18 | 津莫吉尼蒂克斯公司 | 可溶性ZcytoR14、抗ZcytoR14抗体和结合伴侣以及在炎症中的使用方法 |
| US20070249533A1 (en) | 2005-09-28 | 2007-10-25 | Levin Steven D | Il-17a and il-17f antagonists and methods of using the same |
| WO2007038703A2 (en) * | 2005-09-28 | 2007-04-05 | Zymogenetics, Inc | Il-17a and il-17f antagonists and methods of using the same |
| ATE467640T1 (de) | 2006-02-10 | 2010-05-15 | Zymogenetics Inc | Lösliches il-17rcx4 und verfahren zu dessen anwendung bei entzündungen |
| CA2679588A1 (en) | 2007-03-26 | 2008-10-02 | Zymogenetics, Inc. | Soluble il-17ra/rc fusion proteins and related methods |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024196099A1 (ko) * | 2023-03-17 | 2024-09-26 | 주식회사 큐로젠 | 자가면역질환 치료용 신규 융합단백질 |
Also Published As
| Publication number | Publication date |
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| CA2679588A1 (en) | 2008-10-02 |
| US7790676B2 (en) | 2010-09-07 |
| US8242072B2 (en) | 2012-08-14 |
| WO2008118930A1 (en) | 2008-10-02 |
| JP2010522564A (ja) | 2010-07-08 |
| US20110014656A1 (en) | 2011-01-20 |
| US8084231B2 (en) | 2011-12-27 |
| CN101679497A (zh) | 2010-03-24 |
| IL200808A0 (en) | 2010-05-17 |
| EP2125880A1 (en) | 2009-12-02 |
| US20120289684A1 (en) | 2012-11-15 |
| AU2008230843B2 (en) | 2012-08-30 |
| EA200901154A1 (ru) | 2010-04-30 |
| AU2008230843A1 (en) | 2008-10-02 |
| MX2009010273A (es) | 2009-10-12 |
| US20080241138A1 (en) | 2008-10-02 |
| US20120082668A1 (en) | 2012-04-05 |
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| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |