JP2010522564A - 可溶性ｉｌ−１７ｒａ／ｒｃ融合タンパク質および関連する方法 - Google Patents

可溶性ｉｌ−１７ｒａ／ｒｃ融合タンパク質および関連する方法 Download PDF

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JP2010522564A
JP2010522564A JP2010501176A JP2010501176A JP2010522564A JP 2010522564 A JP2010522564 A JP 2010522564A JP 2010501176 A JP2010501176 A JP 2010501176A JP 2010501176 A JP2010501176 A JP 2010501176A JP 2010522564 A JP2010522564 A JP 2010522564A
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seq
polypeptide
amino acid
disease
cells
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JP2010522564A5 (enExample
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スティーブン ディー． レービン
マーク ダブリュー． リクソン
ゼレン ガオ
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ザイモジェネティクス， インコーポレイテッド
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07—ORGANIC CHEMISTRY
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    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

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  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
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JP2010501176A 2007-03-26 2008-03-26 可溶性ｉｌ−１７ｒａ／ｒｃ融合タンパク質および関連する方法 Withdrawn JP2010522564A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11/691,000 US20070249533A1 (en) 2005-09-28 2007-03-26 Il-17a and il-17f antagonists and methods of using the same
US90855407P 2007-03-28 2007-03-28
US98382207P 2007-10-30 2007-10-30
PCT/US2008/058190 WO2008118930A1 (en) 2007-03-26 2008-03-26 Soluble il-17ra/rc fusion proteins and related methods

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JP2010522564A true JP2010522564A (ja) 2010-07-08
JP2010522564A5 JP2010522564A5 (enExample) 2011-04-21

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US (4) US7790676B2 (enExample)
EP (1) EP2125880A1 (enExample)
JP (1) JP2010522564A (enExample)
KR (1) KR20100015750A (enExample)
CN (1) CN101679497A (enExample)
AU (1) AU2008230843B2 (enExample)
CA (1) CA2679588A1 (enExample)
EA (1) EA200901154A1 (enExample)
IL (1) IL200808A0 (enExample)
MX (1) MX2009010273A (enExample)
WO (1) WO2008118930A1 (enExample)

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JP2015535427A (ja) * 2012-11-20 2015-12-14 ノバルティス アーゲー ポリペプチドを高収量で発現するための最適化発現カセット
WO2019216422A1 (ja) * 2018-05-10 2019-11-14 学校法人東京理科大学 制御性Ｔ細胞増加剤、クロストリジウム・クラスターＸＩＶａ菌の増殖促進剤、及び炎症性又はアレルギー性の疾患又は症状の予防、治療、又は改善のための組成物

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JP2010522564A (ja) 2007-03-26 2010-07-08 ザイモジェネティクス， インコーポレイテッド 可溶性ｉｌ−１７ｒａ／ｒｃ融合タンパク質および関連する方法
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JPWO2011096438A1 (ja) * 2010-02-03 2013-06-10 国立大学法人 東京大学 腸疾患の治療方法及び治療用医薬組成物
EP2569335B1 (en) * 2010-05-14 2018-08-22 Orega Biotech Methods of treating and/or preventing cell proliferation disorders with il-17 antagonists
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EP2670426B1 (en) 2011-01-31 2017-05-10 The General Hospital Corporation Multimodal trail molecules and uses in cellular therapies
ES2608835T3 (es) * 2011-04-13 2017-04-17 Bristol-Myers Squibb Company Proteínas de fusión Fc que comprenden nuevos enlazadores o disposiciones
UA117218C2 (uk) 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
CN102688503A (zh) * 2012-06-20 2012-09-26 中国农业大学 一种促进狐狸增重的药物组合物
CN102688504A (zh) * 2012-06-20 2012-09-26 中国农业大学 一种促进水貂增重的药物组合物
WO2014018113A1 (en) 2012-07-24 2014-01-30 The General Hospital Corporation Oncolytic virus therapy for resistant tumors
WO2014035474A1 (en) 2012-08-30 2014-03-06 The General Hospital Corporation Compositions and methods for treating cancer
EP3082834B1 (en) 2013-12-11 2020-03-11 The General Hospital Corporation DBA Massachusetts Stem cell delivered oncolytic herpes simplex virus and methods for treating brain tumors
CN107857818A (zh) * 2017-08-07 2018-03-30 上海科新生物技术股份有限公司 一种针对IL‑17和TNF‑α的双特异性融合蛋白
CN116751277A (zh) * 2023-01-10 2023-09-15 武汉爱博泰克生物科技有限公司 利用毕赤酵母表达活性重组人il-17a蛋白的方法
KR20240141144A (ko) * 2023-03-17 2024-09-25 주식회사 큐로젠 자가면역질환 치료용 신규 융합단백질
CN121081604A (zh) * 2025-03-26 2025-12-09 中国科学院上海营养与健康研究所 Il-17rel融合蛋白在炎症性肠病治疗中的应用

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