KR20080105120A - 키메라 아데노바이러스 벡터 - Google Patents
키메라 아데노바이러스 벡터 Download PDFInfo
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Abstract
Description
Claims (28)
- 하기 요소들:(a) 톨-유사 수용체-3(TLR-3) 효현제를 코딩하는 핵산에 작동가능하게 연결된 제1 프로모터; 및(b) 이종 폴리펩티드를 코딩하는 핵산에 작동가능하게 연결된 제2 프로모터를 포함하는 발현 카세트를 포함하는, 키메라 아데노바이러스 발현 벡터.
- 제1항에 있어서, TLR-3 효현제를 코딩하는 핵산이 dsRNA를 코딩하는 핵산을 포함하는 것인 키메라 아데노바이러스 발현 벡터.
- 제1항에 있어서, TLR-3 효현제를 코딩하는 핵산이 서열 번호: 3, 4, 5, 8, 9, 10, 11, 및 12로 구성된 군으로부터 선택되는 서열을 포함하는 것인 키메라 아데노바이러스 발현 벡터.
- 제1항에 있어서, 이종 폴리펩티드가 HIV env 폴리펩티드인 키메라 아데노바이러스 발현 벡터.
- 제4항에 있어서, HIV env 폴리펩티드가 gp41, gp120, 및 gp160으로 구성된 군으로부터 선택되는 것인 키메라 아데노바이러스 발현 벡터.
- 제1항에 있어서, 이종 폴리펩티드가 인플루엔자 HA 폴리펩티드인 키메라 아데노바이러스 발현 벡터.
- 제1항에 있어서, 제1 프로모터 및 제2 프로모터가 동일한 것인 키메라 아데노바이러스 발현 벡터.
- 제7항에 있어서, 제1 프로모터 및 제2 프로모터가 각각 CMV 프로모터인 키메라 아데노바이러스 발현 벡터.
- 제1항의 발현 벡터 및 약제학적으로 허용가능한 담체를 포함하는 면역원성 조성물.
- 포유동물 대상자에게 제1항의 벡터를 면역학적 유효량으로 투여하는 것을 포함하되, 여기서, 면역 반응은 이종 폴리펩티드에 대한 것이고, 투여 경로는 경구, 비내, 및 점막으로 구성된 군으로부터 선택되는 것인, 면역 반응을 유도하는 방법.
- 제10항에 있어서, 이종 폴리펩티드가 가지 세포, 미세주름 세포, 및 장 상피 세포로 구성된 군으로부터 선택되는 세포에서 발현되는 것인 방법.
- 제10항에 있어서, 포유동물이 인간인 방법.
- (a) 이종 폴리펩티드를 코딩하는 핵산에 작동가능하게 연결된 프로모터를 포함하는 키메라 아데노바이러스 발현 벡터;(b) TLR-3 효현제; 및(c) 약제학적으로 허용가능한 담체를 포함하는 면역원성 조성물.
- 제13항에 있어서, 프로모터가 CMV 프로모터인 조성물.
- 제13항에 있어서, TLR-3 효현제가 dsRNA 및 폴리 I:C로 구성된 군으로부터 선택되는 것인 조성물.
- 제13항에 있어서, 이종 폴리펩티드가 HIV env 폴리펩티드인 조성물.
- 제16항에 있어서, HIV env 폴리펩티드가 gp41, gp120, 및 gp160으로 구성된 군으로부터 선택되는 것인 조성물.
- 제13항에 있어서, 이종 폴리펩티드가 인플루엔자 HA 폴리펩티드인 조성물.
- 제13항에 있어서, TLR-3 효현제가 이종 폴리펩티드 투여 48시간 이내에 투여 되는 것인 조성물.
- 제13항에 있어서, TLR-3 효현제가 서열 번호: 3, 4, 5, 8, 9, 10, 11, 및 12로 구성된 군으로부터 선택되는 서열을 포함하는 핵산인 조성물.
- 포유동물 대상자에게(a) 이종 폴리펩티드를 코딩하는 핵산에 작동가능하게 연결된 프로모터를 포함하는 키메라 아데노바이러스 발현 벡터;(b) TLR-3 효현제를 투여하는 것을 포함하며,여기서, 면역 반응은 이종 폴리펩티드에 대한 것인, 면역 반응을 유도하는 방법.
- 제21항에 있어서, 프로모터가 CMV 프로모터 및 인간 베타 액틴 프로모터로 구성된 군으로부터 선택되는 것인 방법.
- 제21항에 있어서, 이종 폴리펩티드가 HIV env 폴리펩티드인 방법.
- 제23항에 있어서, HIV env 폴리펩티드가 gp41, gp120, 및 gp160으로 구성된 군으로부터 선택되는 것인 방법.
- 제21항에 있어서, 이종 폴리펩티드가 인플루엔자 HA 폴리펩티드인 방법.
- 제21항에 있어서, TLR-3 효현제가 dsRNA인 방법.
- 제21항에 있어서, TLR-3 효현제가 키메라 아데노바이러스 발현 벡터 투여 48시간 이내에 투여되는 것인 방법.
- 서열 번호: 1, 2, 3, 7, 14, 15 , 16, 또는 17에 기재된 서열을 포함하는 단리된 핵산.
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PCT/US2007/005386 WO2007100908A2 (en) | 2006-02-28 | 2007-02-28 | Chimeric adenoviral vectors |
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