KR20080062224A - Cosmetic composition for alleviating skin irritation comprising rumex crispus l. extract stabilized in nanoliposome - Google Patents

Abstract

A cosmetic composition comprising the extract of Rumex crispus L. is provided to minimize skin irritation caused by cosmetic materials such as lactic acid, glycolic acid, salicylic acid or retinol, and enhance the skin-irritation effects by increasing permeation effects of the extract through stabilization in nanoliposome. A cosmetic composition comprises 0.01-40 wt.% of the extract of Rumex crispus L. based on the total weight of nanoliposome. The nanoliposome is prepared by using a mixture of polyol, surfactant, phospholipid, oil component, fatty acid and water, and is formulated as solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation or spray.

Description

Cosmetic composition for alleviating skin irritation with an anti-liposomal extract stabilized with nanoliposomes {Cosmetic Composition for alleviating Skin Irritation Comprising Rumex Crispus L. Extract Stabilized in Nanoliposome}

The present invention relates to a cosmetic composition, and more particularly, to a cosmetic composition for alleviating skin irritation, including nanoliposomes stabilized by inclusion of an extract.

The skin is an organ that is in constant contact with the external environment. Its main function is to act as a protective barrier against water loss. The stratum corneum of the epidermis is located on the outermost side of the skin and suppresses the loss of moisture and electrolytes out of the skin, thereby preventing the drying of the skin and providing a normal biochemical metabolism of the skin. In addition, it plays an important role in protecting the human body from external physical damage and chemicals or preventing the invasion of bacteria and viruses into the skin.

Contact dermatitis is a local inflammatory reaction that occurs on the skin when an external irritant is applied to the skin. Clinical symptoms include irritation and erythema such as itching, stinging, and burning. Inflammatory stimuli such as erythema, edema, etc., and histologically, edema is found in the dermis and monocytes are observed in the epidermis and dermis. Contact dermatitis may also include irritant contact dermatitis, allergic contact dermatitis, sensory irritation, and phototoxic dermatitis, depending on the clinical symptoms or mechanism of expression. It can be divided into, but the clear distinction between them is difficult and there are many conflicts. A common process for a substance to cause skin irritation is that the substance penetrates the skin, interacts with epidermal or dermal cells to activate the immune system, resulting in an inflammatory response.

In general, many skin-related products contain substances that can cause irritation or inflammation, and more than 10% of people who use personal care products complain of side effects to the skin. A survey of consumers found that over 50% consider themselves sensitive skin. Moreover, recent cosmetics are focused on functional cosmetics (cosmeceutical) that can have a real effect on the skin, so skin side effects due to the use of personal care products such as cosmetics are expected to increase gradually.

Therefore, various methods for alleviating skin irritation have been attempted, for example, a method for removing substances causing skin irritation has been attempted. However, this research is limited because the functional raw material itself often acts as a stimulus source. That is, lactic acid, glycolic acid, glycolic acid, salicylcic acid, retinoid, etc. are included in cosmetics for promoting skin cell regeneration or anti-wrinkle effect, but cause skin irritation. Accordingly, in recent years, many studies have been conducted to relieve stimulation by neutralizing acidity by adding strong alkalis such as NaOH or KOH to stimulus-inducing functional raw materials, but such a prescription has a problem of lowering the efficacy of existing raw materials.

Accordingly, the present inventors studied to find a stimulant-releasing substance having an anti-inflammatory effect while maintaining the effect of a functional raw material as it is, and as a result, by extracting the sorbus widely used in folk medicine from the prior patent application and using it as a cosmetic ingredient. It has been confirmed that it shows excellent skin irritation effect.

Applicant of the present patent application has been applied for and registered a cosmetic composition for alleviating skin irritation containing the extract as an active ingredient (Registration No. 10-638053).

 However, the extracts are not only unstable itself but also have a big problem in the stability of the cosmetics, such as precipitation of the contents, color change, etc. when applying the cosmetics.

The present inventors have diligently researched to solve such stability problems and develop cosmetic compositions with improved skin irritation-reducing effects. The present invention has been completed.

An object of the present invention is to provide a cosmetic composition for alleviating skin irritation comprising nanoliposomes stabilized by inclusion of the Soru-Ji extract as an active ingredient.

According to an aspect of the present invention, the present invention provides a cosmetic composition for alleviating skin irritation comprising nanoliposomes stabilized by inclusion of Rumex crispus extract as an active ingredient.

Rumex crispus is called perennial herb, which is called yangje-geun, candid, and muzzle. It is a perennial herb that grows dry in midsummer and grows again when cool. Young leaves are eaten as herbs and are effective for ringworm, athlete's foot, eczema, etc. Since ancient times, it has been used in skin diseases such as amelioration, scabies and skin cancer, and it is also used for cystitis and colitis. In the fall, the roots were rolled round and dried in the sun, called Yangje-geun, which was substituted for the Chinese medicine called rhubarb.

Soru-Ji extract, the active ingredient of the cosmetic composition of the present invention, has a cytostimulatory and anti-inflammatory effect from a stimulus source.

In the present invention, the extract is derived from various organs or parts (eg, leaves, flowers, roots, stems, branches, shells, fruits, etc.) of the sarcasm, preferably all organs of the sarcasm. Means an extract obtained from the whole of the grass.

The extracts of the present invention can be obtained using various extraction methods known in the art, preferably, water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol, etc.), It can be obtained as an extraction solvent by selecting any one of the extraction solvent consisting of a mixture of the lower alcohol and water, acetone, ethyl acetate, chloroform and 1,3-butylene glycol.

On the other hand, it will be apparent to those skilled in the art that the extracts of the present invention can be obtained by extracting Soru-Jin extracts having substantially the same effect using not only the aforementioned extraction solvent but also other extraction solvents.

In addition, the extract of the present invention includes not only the extract by the above-described extraction solvent, but also the extract that has undergone a conventional purification process. Obtained by various additional purification methods, such as, for example, separation using an ultrafiltration membrane having a constant molecular weight cut-off value, separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity). The fraction is also included in the extract of the present invention.

Soruja extract of the present invention may be prepared in a powder state by an additional process such as vacuum distillation and freeze drying or spray drying.

According to a preferred embodiment of the present invention, the extract is 0.001-40% by weight, more preferably 0.1-25% by weight based on the total weight of nanoliposomes.

As used herein, the term "nanoliposomes" refers to liposomes having an average particle diameter of 1-100 nm as having the form of conventional liposomes. According to a preferred embodiment of the invention, the average particle diameter of the nanoliposomes is 30-70 nm. When the average particle diameter of the nanoliposomes exceeds 70 nm, the improvement of skin penetration and the improvement of formulation stability are very weak among the technical effects to be achieved in the present invention.

Nanoliposomal system has the advantage of dissolving various kinds of poorly soluble substances and stabilizing unstable substances to maximize skin penetration effect.

As used herein, the term 'envelopment' means that the nanoliposome is wrapped in the extract of Soru-lung, and the Soru-lung extract is contained in the nano-liposome.

The preparation of nanoliposomes can be accomplished through various methods known in the art, but most preferably, a mixture comprising the above components is applied to a high pressure homogenizer. The preparation of nanoliposomes by high pressure homogenizer can be carried out under various conditions (eg pressure, frequency, etc.) depending on the desired particle size, preferably 1-5 times high pressure homogenizer under 600-1200 bar pressure. Nanoliposomes are prepared by passing through.

In the composition of the present invention, the content of the nanoliposomes is preferably 0.1-20.0% by weight based on the total weight of the cosmetic composition. If the content of the nanoliposome is less than 0.1% by weight can not expect a clear skin irritation effect, when the content exceeds 20.0% by weight does not appear to increase the apparent effect of increasing the content.

The nanoliposomes of the present invention are prepared by a mixture comprising polyols, surfactants, phospholipids, oily ingredients, fatty acids and water, and are characterized by not using monohydric alcohols (eg ethanol). If monohydric alcohol is added, the stability of nanoliposomes is not used.

The polyol used in the nanoliposome of the present invention is not particularly limited, and preferably, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, methylpropanediol, isoprene glycol, pentylene glycol, erythritol, ziitol and Sorbitol, most preferably propylene glycol. The amount used is 10-80% by weight, preferably 30-70% by weight based on the total weight of the nanoliposomes.

Surfactants used in the preparation of the nanoliposomes of the present invention may be any known in the art, for example, anionic surfactants, cationic surfactants, amphoteric surfactants and nonionic surfactants may be used. , Preferably anionic surfactants and nonionic surfactants are used. Specific examples of anionic surfactants include alkylacylglutamate, alkylphosphates, alkyllactylates, dialkylphosphates, alkyllactates and trialkylphosphates. Specific examples of nonionic surfactants include alkoxylated alkyl ethers, alkoxylated alkyl esters, alkylpolyglycosides, polyglyceryl esters and sugar esters. Preferably, it is a mixture of said anionic surfactant and nonionic surfactant. More preferably, the anionic surfactant is alkyl lactate, and the nonionic surfactant is polysorbate. Most preferably, the alkyl lactate is sodium stearoyl lactate. The amount of the surfactant to be used is generally 0.1-10% by weight, preferably 0.3-5.0% by weight based on the total weight of the nanoliposomes.

Phospholipids, another component used in the preparation of the nanoliposomes of the present invention, are used as amphoteric lipids, including natural phospholipids (eg, egg yolk lecithin or soy lecithin, sphingomyelin) and synthetic phospholipids (eg dipalmitoyl). Phosphatidylcholine or hydrogenated lecithin), preferably lecithin. Most preferably, the lecithin is hydrogenated lecithin. In preparing the nanoliposomes of the present invention, the amount of lecithin used is 0.5-8% by weight, preferably 2-8% by weight, based on the total weight of the nanoliposomes.

The oil component used in the preparation of the nanoliposomes of the present invention may be various oils known in the art, for example, hydrocarbon-based oils such as hexadecane and paraffin oil, isopropyl myristate and Animal oils such as synthetic oils of the same ester type, silicone oils such as dimethicone and cyclomethicone series, sunflower oil, corn oil, soybean oil, avocado oil, sesame oil, jojoba oil, nut oil, squalane and fish oil. Sphingonoid lipids, such as ethoxylated alkylether based oils, propoxylated alkylether based oils, phytosphingosine, sphingosine and sphinginine, cerebrosides, cholesterol, cytosterols, cholesteryl sulfates, cytosine _{Sterylsulfate} , C _10-40 fatty alcohol or ceramide. Preferably, hydrocarbon oils such as hexadecane and paraffin oil, silicone oils such as dimethicone and cyclomethicone, or sunflower oil, corn oil, soybean oil, avocado oil, sesame oil, jojoba oil, nut oil, squalane and It is a copper vegetable oil such as fish oil. Preferred among hydrocarbon oils are paraffin oils, preferred isopropyl myristate among ester oils, dimethicone is preferred among silicone oils, and nut oils and squalanes are preferred among animal and vegetable oils. More preferably, it is paraffin oil, isopropyl myristate, dimethicone, squalane or nut oil, most preferably a mixture of the five oils. The amount used is 2-30% by weight based on the total weight of nanoliposomes, preferably 3-20.0% by weight.

The fatty acids used in the preparation of the nanoliposomes of the present invention are higher fatty acids, preferably saturated or unsaturated fatty acids of the C _12-22 alkyl chain, such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid and linoleic acid. It includes. Most preferably stearic acid. The content of fatty acid is 0.05-3.0% by weight, preferably 0.1-1.0% by weight relative to the total weight of nanoliposomes.

The water used in the preparation of the nanoliposomes of the present invention is generally deionized distilled water, the amount of which is used is 3.0-20% by weight based on the total weight of the nanoliposomes.

The components included in the cosmetic composition of the present invention include components conventionally used in cosmetic compositions in addition to nanoliposomes including the extracts as an active ingredient, such as stabilizers, solubilizers, vitamins, pigments and flavorings. Adjuvants, and carriers.

The cosmetic composition for alleviating the skin irritation of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, interfaces It may be formulated as an active agent-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, spray, and the like. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylene glycol, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, Crystalline cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The present invention relates to a cosmetic composition comprising a nanoliposome stabilized by inclusion of an extract of Soru-Ji extract, and more particularly, to a cosmetic composition for alleviating skin irritation comprising the nano-liposome stabilized by inclusion of an extract of So-Ru-Ji extract as an active ingredient. will be.

The cosmetic composition of the present invention has the effect of greatly reducing skin irritation caused by cosmetic raw materials and preventing and treating inflammation developed by skin irritation. This fact is specified in the following examples.

Furthermore, in the cosmetic composition of the present invention, since the extract is contained by the nanoliposomes, the skin penetration effect is greatly increased, the skin irritation relieving effect is greatly improved, and the stability of the formulation is also greatly improved.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident.

Preparation Example 1 Preparation of Soru-Zip Extract

1 kg of finely cut Rumex crispus was precipitated in an aqueous solution of ethyl alcohol and water at 7: 3 (v / v) for 5 days, filtered over 300 mesh, and then vacuum dried at 80 ° C. using a vacuum concentrator. Concentrated. Thus obtained powder was 33.3 g, which was dissolved in 1,3-butylene glycol for easy application to the product again. Soruja powder was dissolved in 10% by weight in 30% 1,3-butylene glycol solution was used in the present invention.

Preparation Example 2 Preparation of Nanoliposomes Containing Soru-Zip Extract

To prepare nanoliposomes, phase B was added to phase A in the composition of Table 1 below, followed by uniform wetting, followed by phase C addition and heat mixing to 70-80 ° C. The solution was passed through a high-pressure homogenizer (Microfluidizer M-110F, Microfluidics International Corporation) 2-4 times under conditions of 600-1000 bar, cooled, and surrounded by stabilizer by inclusion of the extract of Soru-Jin (Preparation Example 1). Particle sized nanoliposomes were obtained.

Preparation of Nanoliposomes Prize ingredient Content (% by weight) A glycerin To 100 B Hydrogenated lecithin 5.0 Floating paraffin 1.0 Macadamia Nut Oil 1.0 Squalane 1.0 Dimethicone 1.0 Isopropyl myristate 1.0 Sodium Stearoyl Lactate 0.5 Polysorbate-80 0.5 Stearic acid 0.5 C Soru-Jin Extract [Manufacturing Example 1] 20.0 Potassium hydroxide Quantity Purified water 5.0

Production Example  3. Rumor  Extracts In a hurry  Stabilized Nanoliposomes  Preparation of cosmetic composition containing

Comparative Example 1. Preparation of a cosmetic composition comprising the extract

A cosmetic composition (Comparative Example 1) comprising the extract of Soru-Ji extract and a cosmetic composition (Preparation Example 3) comprising the nanoliposome stabilized by inclusion of the extract of Soru-Ji was prepared in the following composition.

Preparation Example 3 and Comparative Example 1 ingredient Preparation Example 3 Comparative Example 1 Content (% by weight) Content (% by weight) Nanoliposome containing Soru-Ji extract [Preparation Example 2] 10.0 (containing 2% of the creeper extract) - Rumor  extract[ Production Example  One] - 2.0 A Cetostearyl alcohol 2.0 2.0 Glyceryl Stearate 1.5 1.5 Mikey-Crystalline 0.7 0.7 Squalane 5.0 5.0 Liquid paraffin 3.0 3.0 Trioctanoine 5.0 5.0 Polysorbate 1.2 1.2 Sorbitan stearate 0.5 0.5 Tocopherol Acetate 0.2 0.2 Micromethicone 3.0 3.0 BHT 0.05 0.05 B glycerin 4.0 4.0 1,3-butylene glycol 2.0 2.0 EDTA-2Na 0.05 0.05 Purified water To 100 To 100 Incense, preservative Quantity Quantity

Experimental Example  1. Determination of the stability of the formulation

The stability test for the cosmetic composition (Preparation Example 3) containing the nanoliposomes stabilized by inclusion of the above-mentioned Soru-Ji extract of the present invention was carried out by the following method.

To test the stability of the cosmetics, the examples and comparative examples were kept in an opaque glass container in a constant temperature bath at 45 ° C. for 12 weeks and stored in a completely shaded refrigerator kept at 4 ° C. After storage for 12 weeks in a container, the degree of separation and discoloration were measured. The results are summarized in the following [Table 3]. At this time, product separation and discoloration were classified into six grades and evaluated.

 0: no change, 1: very little separation (discoloration), 2: little separation (discoloration), 3: little severe separation (discoloration), 4: severely separation (discoloration), 5: very severe separation (discoloration)

Separation and discoloration Preparation Example 3 Comparative Example 1 45 ℃ 0 2.3 4 ℃ 0 0

As can be seen in Table 3, Preparation Example 3 was stable at 45 ° C. without discoloration or separation, but Comparative Example 1, which was used in direct formulation without using Soru-Zip extract in nanoliposomes, was used at 45 ° C. Not only is the extract unstable due to a slight separation and discoloration, but it can be seen that the extracts were introduced into the formulation and the formulation itself became unstable.

Experimental Example 2. Anti-inflammatory effect evaluation method-Carrageenan Foot Edema

1 hour after administering 10-100 mg / kg of rat liposomal extract [Preparation Example 1] and nanoliposomes [Preparation Example 2] stabilized by incorporating the extracts obtained in Preparation Example 1 and Preparation Example 2 Thereafter, 0.5 ml of 0.1% carrageenan solution (Sigma) was injected into the hind paw of the experimental animal to induce inflammation. Changes in the paw volume of rats were measured immediately after carrageenan injection and 4 hours after injection. The results are shown in Table 4 below.

 Anti-inflammatory effect Dose (mg) % Inhibition Nanoliposome containing Soru-Ji extract [Preparation Example 2] Soru-Jin Extract [Manufacturing Example 1] 10 34.4 20.2 30 47.6 31.7 50 63.9 48.6 100 79.1 57.3

Looking at the above [Table 4], Soru-Jung extract showed an anti-inflammatory effect. In particular, nanoliposomes stabilized by inclusion of Soru-Ji extract showed a remarkably excellent anti-inflammatory effect.

Experimental Example 3. Skin Penetration Effect

The skin penetration effect of the cosmetic composition (Preparation Example 3) containing the nanoliposomes stabilized by inclusion of the rubbing extract of the present invention was measured.

Dermal Equivalent (DE) Preparation-Human Normal Fibroblasts 1 × 10 ⁵ cells / mL (Korea Cell Line Bank) are prepared by inoculating the following medium and incubating at 5% CO ₂ , 37 ° C. for 7 days. The medium composition is as follows. Gel-like collagen aqueous solution (3 mg / mL), 5-fold DMEM concentrated medium and neutralization buffer solution (2.2% NaHCO ₃ , 200 mM / L HEPES, 0.05N NaOH) were 7: 2: 1, respectively. Prepare by mixing.

The culture was placed inside the plate separated by the inside and the outside by a membrane made of 3 μm porous polycarbonate. EGF (Epidernal growth factor) BPE (Bovine Pituitary Extract) was inoculated by inoculating epidermal keratinocyte 1 X 10 ⁵ cell / mL cells on the surface of the skin equivalent (DE) cultured with fibroblasts. K-SFM medium (Keratinocyte serum-free medium, Sigma) was added to the inside and outside and incubated for 7 days. Then, discard the medium inside the plate so that the air comes into contact with the surface of the cultured cells, and put the medium mixed with the same amount of K-SFM containing 10% FBS (Fetal Bovine Serum) and DMEM without EGF. Weekly cultures yielded artificial skin with multiple epidermis and dermis. Here, Preparation Example 3 and Comparative Example 1 of the present invention were applied to the artificial skin tissue of the top layer, and after 4 hours of incubation, the amount of infiltrated phytoncide was analyzed by HPLC. The test results are shown in the following [Table 5].

Amount of Soruja Extract in Medium (%) Preparation Example 3 Comparative Example 1 0.8% 1.9%

Experimental results As shown in [Table 5], the cosmetic composition containing the nanoliposome stabilized by inclusion of the rubbing extract of the present invention (Preparation Example 3) is compared to the skin composition using the rubbing extract as it is (comparative example 1). It can be seen that the penetration effect is excellent. This is because the average particle size of the nanoliposomes of the present invention is very small, 30-70 nm, so that skin penetration is easy. Therefore, as can be seen in the anti-inflammatory effect of Experimental Example 2, Preparation Example 3 of the present invention can be seen that the skin penetration effect is superior to Comparative Preparation Example showing a remarkably excellent anti-inflammatory effect.

Experimental Example  4. Comparison of skin irritation relief effect in human application

For 20 women in their 20s and 30s, 5% lactic acid was added as a stimulant to Preparation Example 3, Comparative Example 1 and Control Example (contents containing no extracts). Ten days of use were used to compare the mitigating effects of lactic acid-induced irritation. Each morning and evening were used, and then questionnaires were marked for irritation and intensity. Evaluation of the test results was performed once a day, and divided into subjective and objective stimuli, and the results are shown in [Table 6] below.

Objective irritation: Visually discernible stimuli that appear externally (erythema, rashes, blisters, peeling skin, etc.)

Subjective irritation: stimulus that manifests itself as subjective feeling, such as itching, stinging, or burning

The numerical values are classified into unstimulated, hard and strong stimuli for each stimulus and weighted to 1, 2, and 3 points, respectively.

(E.g., 1 point if itching is unstimulated, 6 points if burning is 2 with strong stimulation)

Test substance Subjective stimulation Objective stimulus Sum Control 29 17 46 Preparation Example 3 8 7 15 Comparative Example 1 13 10 23

As can be seen from [Table 6], it can be seen that the cosmetics containing 2.0% of Sorruja stabilized with the nanoliposomes obtained according to Preparation Example 2 of the present invention have an excellent effect of alleviating the skin irritation caused by 5% lactic acid. . Hereinafter, based on the results of the above experimental example, to present a cosmetic composition containing the nanoliposomes stabilized by inclusion of the rubbing extract extract of the present invention. However, the composition of the present invention is not intended to be limited to the following formulation examples.

Formulation Example 1. Flexible lotion (skin lotion)

As shown in Table 7, a flexible lotion including nanoliposomes stabilized by inclusion of an extract of Soru-Zi was prepared according to a conventional method.

ingredient Content (% by weight) Nanoliposome containing Soru-Ji extract [Preparation Example 2] 1.0 glycerin 6.0 1,3-butylene glycol 3.0 PEG 1500 1.0 Allantoin 0.1 DL-panthenol 0.3 EDTA-2Na 0.02 Benzophenone-9 0.04 Sodium hyaluronate 5.0 ethanol 10.0 Octicdodeceth-16 0.2 Polysorbate 20 0.2 Preservative, fragrance, coloring a very small amount Purified water Remaining amount Sum 100

Formulation Example 2. Nutritional Lotion (Milk Lotion)

As shown in Table 8, a nutritious lotion including nanoliposomes stabilized by inclusion of the extract of Soru-Ji was prepared according to a conventional method.

ingredient Content (% by weight) Nanoliposome containing Soru-Ji extract [Preparation Example 2] 3.0 Glyceryl Stearate SE 1.5 Stearyl alcohol 1.5 lanolin 1.5 Polysorbate 1.3 Sorbita stearate 0.5 Cured Vegetable Oil 1.0 Mineral oil 5.0 Squalane 3.0 Trioctanoine 2.0 Dimethicone 0.8 Tocopherol Acetate 0.5 Carboxyvinyl Polymer 0.12 glycerin 5.0 1,3-butylene glycol 3.0 Sodium hyaluronate 5.0 Triethanolamine 0.12 Preservative, fragrance, coloring a very small amount Purified water Remaining amount Sum 100

Formulation Example 3. Nutrition Cream

As shown in Table 9, a nutritive cream containing nanoliposomes stabilized by inclusion of an extract of Soru-Ji was prepared according to a conventional method.

ingredient Content (% by weight) Nanoliposome containing Soru-Ji extract [Preparation Example 2] 3.0 Lipophilic monostearate 2.0 Cetearyl Alcohol 2.2 Stearic acid 1.5 Beeswax 1.0 Polysorbate 60 1.5 Sorbitan stearate 0.6 Cured Vegetable Oil 1.0 Squalane 3.0 Mineral oil 5.0 Trioctanoine 5.0 Dimethicone 1.0 glycerin 5.0 Betaine 3.0 Triethanolamine 1.0 Sodium hyaluronate 4.0 Preservative, fragrance, coloring a very small amount Purified water Remaining amount Sum 100

Formulation Example 4 Massage Cream

A massage cream including a nanoliposome stabilized by inclusion of an extract of Sorbus extract as shown in Table 10 was prepared according to a conventional method.

ingredient Content (% by weight) Nanoliposome containing Soru-Ji extract [Preparation Example 2] 3.0 Lipophilic Monostearic Acid Glycerin 1.5 Stearyl alcohol 1.5 Stearic acid 0.1 Polysorbate 60 1.5 Sorbitan stearate 0.6 Isostearyl Isosterate 5.0 Squalane 5.0 Mineral oil 35.0 Dimethicone 0.5 Hydroxyethyl cellulose 0.12 glycerin 6.0 Triethanolamine 0.7 Preservative, fragrance, coloring a very small amount Purified water Remaining amount Sum 100

Formulation Example 5. Essence

As shown in Table 11 below, an essence including nanoliposomes stabilized by inclusion of an extract of Soru-Zi was prepared according to a conventional method.

ingredient Content (% by weight) Nanoliposome containing Soru-Ji extract [Preparation Example 2] 3.0 glycerin 10.0 Betaine 5.0 PEG 1500 2.0 Allantoin 0.1 DL-panthenol 0.3 EDTA-2Na 0.02 Benzophenone-9 0.04 Hydroxyethyl cellulose 0.1 Sodium hyaluronate 8.0 Carboxyvinyl Polymer 0.2 Triethanolamine 0.18 Octyldodecanol 0.3 Octyldodeceth-16 0.4 ethanol 6.0 Preservative, fragrance, coloring a very small amount Purified water Remaining amount Sum 100

Formulation Example 6 Pack

As shown in Table 12, a pack including nanoliposomes stabilized by inclusion of an extract of Soru-Zi was prepared according to a conventional method.

ingredient Content (% by weight) Nanoliposome containing Soru-Ji extract [Preparation Example 2] 3.0 Polyvinyl alcohol 15.0 Cellulose gum 0.15 glycerin 3.0 PEG 1500 2.0 Chicdestrin 0.15 DL-panthenol 0.4 Allantoin 0.1 Glycyrisin Monoammonium 0.3 Nicotinamide 0.5 ethanol 6.0 PEG 40 Cured Castor Oil 0.3 Preservative, fragrance, coloring a very small amount Purified water Remaining amount Sum 100

As described above, the present invention provides a cosmetic composition comprising a nanoliposome stabilized by inclusion of the Sorujeuk extract. The cosmetic composition of the present invention alleviates skin irritation caused by skin irritant raw materials contained in general cosmetics and functional cosmetics.

Applicant of the present invention applied for and registered a skin irritation cosmetic composition containing soruja extract as an active ingredient (Registration Patent No. 638053), the present invention stabilizing the extract from Soruju extract with nanoliposomes than the registered patent Penetration effect is better than about 10 times or more can be confirmed through Experimental Example 3.

In other words, in the cosmetic composition of the present invention, the extract of Soru-Jin is contained by the nanoliposomes, so the skin penetration effect is greatly increased, the skin irritation-reducing effect is greatly improved, and the stability of the formulation is also greatly improved.

Claims (4)

A cosmetic composition for alleviating skin irritation comprising nanoliposomes stabilized by inclusion of Rumex crispus L. extract as an active ingredient. The cosmetic composition for alleviating skin irritation according to claim 1, wherein the extract is contained in an amount of 0.01-40% by weight based on the total weight of nanoliposomes. The cosmetic composition for alleviating skin irritation of claim 1, wherein the nanoliposomes are prepared by a mixture comprising a polyol, a surfactant, a phospholipid, an oily component, a fatty acid, and water. The composition of claim 1 wherein the cosmetic composition consists of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray A cosmetic composition for alleviating skin irritation, which has a formulation selected from the group.