KR101486794B1 - Cosmetic effective in relaxation of striae distensae containing nano liposome glycolic acid - Google Patents

Abstract

The present invention relates to a cosmetic ingredient effective in alleviating striae distensae which contains glycolic acid made into nano liposomes. More specifically, glycolic acid, which stimulates fibroblasts to help collagen synthesis, is made into nano liposomes to be easily permeated into skin so that the effect can be maximized with a small quantity thereof and skin irritation is minimized. The cosmetic ingredient effective in alleviating striae distensae containing glycolic acid made into nano liposomes according to the present invention includes glycolic acid made into nano liposomes as an active ingredient, wherein 0.05-2 wt% of the glycolic acid made into nano liposomes is included based on the total weight thereof.

Description

COSMETIC EFFECTIVE IN RELAXATION OF STRIAE DISTENSIVE CONTAINING NANO LIPOSOME GLYCOLIC ACID BACKGROUND OF THE INVENTION 1. Field of the Invention [0001]

The present invention relates to a cosmetic useful for alleviating stretch marks containing nanoliposomalized glycolic acid. More particularly, the present invention relates to a cosmetic composition which stimulates fibroblasts to nanoliposomalize glycolic acid to facilitate penetration into the skin, The present invention relates to a cosmetic useful for minimizing skin irritation and minimizing skin stretch which can maximize the effect with a small amount.

Skin is the most outwardly located tissue of the human body, accounting for about 7% of normal adult body weight. It is a very important tissue that has chemical and physical functions while protecting the human body from external influences and interacting with the external environment.

Skin tissue is largely divided into epidermis, dermis and subcutaneous fat and they work together organically.

The dermis consists of the papillary layer which is in contact with the epidermal layer, which is about 90% of the skin, which is about 90% of the skin, and the reticular layer which is composed of the collagen fiber and the elastic fiber (elastin).

Stretch is a skin condition that can occur in both men and women, and it is known to occur especially in the belly, thighs, chest, shoulders, and calves of pregnant women and adolescents growing up.

Maternal stretch marks the biggest cause of skin enlargement due to the growth of the fetus, which increases the production and secretion of collagenase, collagenase, due to hormonal changes during pregnancy. The increase in collagenase results in the collapse of collagen tissues, resulting in red lines that degrade the elasticity of the skin corresponding to overgrowth due to the growth of the fetus.

The stretch marks of teenage youths are caused by collapse of tissue and damages of skin layer to make red lines because collagen and elasticity of skin retention factors such as skin elasticity can not cope with sudden skeletal change and change of body shape.

At the beginning of stretch marks, red color often accompanies the symptoms of itching or burning. It is slightly slacker than the normal skin and it feels rugged when touched. Over time, the skin becomes reddish due to its natural regeneration ability, and a new whitish (white) is buried in the area where it becomes red.

Citric acid (citric acid), which is an AHA (Alpha-Hydroxy Acid) used in existing patent for expansion filament, is not easy to penetrate the skin because of its high molecular weight. It has also been found that citric acid added to hydroxyethylcellulose precipitates during the manufacturing process when applied to ophthalmic and cream preparations.

Disclosure of the Invention The present invention has been conceived to solve the problems of the prior art as described above, and it is an object of the present invention to provide a skin barrier comprising glycolic acid, which stimulates fibroblasts to assist in collagen synthesis, as a component of ceramide, cholesterol, Minimizes the amount of contact with the skin through nanoliposomalization, minimizes irritation to the skin, and improves the penetration of the skin. Therefore, it can provide a superior collagen synthesis even when used in a small amount, It is an object of the present invention to provide a cosmetic useful for alleviating stretch marks containing overcomeable nano-liposomalized glycolic acid.

The problems to be solved by the present invention are not limited to those mentioned above, and other problems to be solved can be clearly understood by those skilled in the art from the following description.

To achieve the above object, the present invention provides a cosmetic useful for alleviating stretch marks containing nanoliposomalized glycolic acid, which comprises nanoliposomalized glycolic acid as an active ingredient.

In addition, cosmetics which are effective for relaxation of stretch marks containing nanoliposomized glycolic acid according to the present invention are characterized in that the nanoliposomized glycolic acid contains 0.05 to 2% by weight based on the total weight.

In addition, the cosmetic useful for alleviating stretch marks containing nanoliposomalized glycolic acid according to the present invention is characterized in that the nanoliposomalized glycolic acid is mixed with ceramide, cholesterol and fatty acid to form nanoliposomes.

In addition, the cosmetic useful for alleviating stretch marks containing nanoliposomalized glycolic acid according to the present invention comprises 0.1 to 5 parts by weight of ceramide, 0.1 to 5 parts by weight of cholesterol and 0.1 to 5 parts by weight of fatty acid, And a nano-liposome.

In addition, the cosmetic useful for alleviating stretch marks containing nanoliposomalized glycolic acid according to the present invention is characterized by further comprising at least one selected from the group consisting of allantoin, march extract, locust extract, and green tea extract .

In addition, the cosmetics effective to alleviate stretch marks containing nanoliposomized glycolic acid according to the present invention contain 0.1 to 5 parts by weight of allantoin, 0.05 to 2 parts by weight 0.05 to 2 parts by weight of the extract, and 0.05 to 2 parts by weight of the green tea extract.

In addition, the cosmetics useful for alleviating stretch marks containing nanoliposomalized glycolic acid according to the present invention are characterized by being any one of a skin preparation, a gel preparation, a rosewater preparation and a cream preparation.

According to the present cosmetic composition containing nanoliposomalized glycolic acid according to the present invention, glycolic acid which stimulates fibroblasts to help collagen synthesis is used as a component of skin barrier, such as ceramide, cholesterol , Minimizes the amount of contact with the skin through nanoliposomalization of glycolic acid including fatty acids, minimizes irritation to the skin, and improves skin permeability, which can greatly contribute to collagen synthesis even when used in small amounts, It is possible to provide a cosmetic which is effective for relaxation of stretch marks containing nano-liposomalized glycolic acid which can overcome manufacturing process and stability problem of formulation.

The effects attained by the present invention are not limited to those mentioned above, and other effects not mentioned can be clearly understood by those skilled in the art from the following description.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a conceptual diagram of a nanoliposomalization device in cosmetics which is effective for stretch-thinning containing nanoliposomalated glycolic acid according to the present invention. Fig.
Figure 2 is a graph showing the nanoliposomalization of glycolic acid in cosmetics which is effective for stretch relaxation containing nanoliposomalated glycolic acid according to the present invention.
FIG. 3 is a graph showing the effect of improving the stretch marks of Example 1 of a cosmetic useful for alleviating stretch marks containing nanoliposomalized glycolic acid according to the present invention. FIG.
FIG. 4 is a graph showing satisfaction of skin elasticity for Example 1 of a cosmetic useful for relaxation of stretch marks containing nanoliposomalized glycolic acid according to the present invention. FIG.
FIG. 5 is a graph showing the satisfaction of the moisturizing sustainability of Example 1 of a cosmetic composition effective for stretch relaxation containing nanoliposomalized glycolic acid according to the present invention. FIG.
FIG. 6 is a graph showing the preference for the cosmetic composition of Example 1 and Comparative Example 1 which is effective for stretch relaxation containing nanoliposomalized glycolic acid according to the present invention. FIG.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the following description. However, the present invention is not limited to the embodiments described herein but may be embodied in other forms. Rather, the embodiments disclosed herein are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. Like numbers refer to like elements throughout.

Fig. 1 is a conceptual view of a nanoliposome-forming device in cosmetics which is effective for stretch-reducing the nano-liposomized glycolic acid according to the present invention, and Fig. 2 is a schematic view of a nano-liposomized glycolic acid- FIG. 3 is a graph showing the effect of improving the stretch marks of Example 1 of a cosmetic material effective for stretch-reducing with nanoliposomalized glycolic acid according to the present invention, and FIG. Is a graph showing the satisfaction of skin elasticity with respect to Example 1 of a cosmetic effective in stretch-reducing with nanoliposomized glycolic acid according to the present invention, and Fig. 5 is a graph showing the satisfaction FIG. 6 is a graph showing the satisfaction of the moisturizing sustainability with respect to Example 1 of cosmetics effective for stretch loosening, and FIG. Another is a graph showing the affinity for the Comparative Example 1 and Example 1 of cosmetic effective for mitigating stretch containing the nanoliposome Chemistry glycolic acid.

The cosmetics which are effective for relaxation of stretch marks containing nanoliposomalized glycolic acid according to the present invention may comprise nanoliposomalized glycolic acid as an active ingredient.

Glycolic Acid, which has a relatively small molecular weight (76) compared to citric acid (citric acid) having a molecular weight of 192, is a natural ingredient extracted mainly from sugarcane and stimulates fibroblasts to help in the synthesis of collagen, Is known to be a component of skin brightening effect, but its direct use may be limited because it is low in acidity and may cause instability in the prescription and irritation to the skin.

Accordingly, the present invention minimizes the amount of contact with the skin through minimization of nanoliposomes of glycolic acid including ceramide, cholesterol, and fatty acid which constitute skin barrier, thereby minimizing irritation to the skin, It improves the penetration power and helps the collagen synthesis to be superior even when used in a small amount, and it is configured to overcome the manufacturing process and stability problem of the formulation.

More specifically, the cosmetic material effective for alleviating stretch marks containing nanoliposomalized glycolic acid according to the present invention can be formed by nanoliposomized glycolic acid mixed with glycolic acid, ceramide, cholesterol, fatty acid, etc. .

Glycolic acid is made into a nanoliposome using an apparatus as shown in the conceptual diagram of the nanoliposome formation apparatus of FIG. That is, when lipid components such as ceramide, cholesterol, and fatty acid, which constitute the stratum corneum of the skin, are mixed with glycolic acid as a key ingredient and heated and stirred to increase the activity, lipid components collect glycolic acid as a key ingredient, . When a micro-tube is passed through a pressurized pump system, a small size glycolic acid liposome is formed due to the activity of stressed contents. This process is repeated several times, and a nano-sized liposome having a multi- do. The glycolic acid nanoparticle size determination test was performed using a ZETASIZER 3000HSA [Malvern Instruments Ltd. England; and Figure 2 shows the nanoliposomalization of glycolic acid.

The mixing ratio of the lipid component such as ceramide, cholesterol, and fatty acid and glycolic acid as a core component is 0.1 to 5 parts by weight of ceramide, 0.1 to 5 parts by weight of cholesterol and 0.1 to 5 parts by weight of fatty acid to 0.1 to 20 parts by weight of glycolic acid Can be configured.

In addition to the above-mentioned substances, lecithin is used as a constituent substance which becomes a base upon the formation of liposomes in the nanoliposomalization of glycolic acid, and it is preferably composed of 10 to 50 parts by weight with respect to 0.1 to 20 parts by weight of the glycolic acid. Lecithin is a component of phospholipids and is one of the constituent components of the liposome membrane. It is a natural surfactant harmless to the skin and helps safe penetration of the active ingredient into the skin.

The composition may further comprise fatty acid esters, vegetable oils and vitamin E derivatives in addition to the ceramide, cholesterol, and fatty acids. The composition may further comprise 1 to 10 parts by weight of a fatty acid ester, 1 to 5 parts by weight of a vegetable oil And vitamin E derivatives in an amount of 0.01 to 1 part by weight.

The cosmetic material useful for alleviating stretch marks containing nanoliposomalized glycolic acid according to the present invention may comprise 0.05 to 2% by weight of the nanoliposomalized glycolic acid based on the total weight of the cosmetic, and may be an allantoin, Position hyaluronan extract, and green tea extract.

0.1 to 5 parts by weight of allantoin, 0.05 to 2 parts by weight of mallow extract, 0.05 to 2 parts by weight of extract of locust bean, and 0.05 to 2 parts by weight of extract of oriental jelly, respectively, in 0.05 to 2 parts by weight of nanoliposomalized glycolic acid. To 2 parts by weight of the green tea extract, and 0.05 to 2 parts by weight of the green tea extract.

In the present invention, the allantoin is a white crystalline material widely distributed in plants and animals such as tobacco seed, sugar beet, wheat embryo, and urine as a purine base metabolite. The allantoin is an annual plant belonging to the genus Porphyra The scientific name is Portulaca oleracea, and the above-mentioned Witch Hazel is a plant of about six species belonging to the genus Hamamelis (科 科 Hamamelidaceae). The green tea is not fermented, It refers to the leaves of tea trees.

The extract used in the present invention can be obtained through various methods known in the art. Preferably, the extract can be obtained by leaching from the marigold, the positional hadgel and green tea, the leaching solution obtained by transferring the leach, or the concentrate obtained by partially or completely concentrating the leaching solution , Or an extract obtained by drying the concentrate again and a chemical substance itself exhibiting a main effect contained in the extract.

As the extraction solvent in the present invention, any one or a mixture of two or more selected from the group consisting of water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol, propylene glycol, dichloromethane and hexane may be used have.

In addition, the extract of the present invention includes not only the extraction method described above, but also the extract extracted by other methods. For example, separation using an ultrafiltration membrane having a constant molecular weight cut-off value; Fractions obtained by various purification methods, such as separation by chromatography produced for various chromatography, for example, separation by size, charge, hydrophobicity or affinity, are also included in the extract of the present invention. Therefore, the present invention is not particularly limited to the method of extracting the complex extract.

On the other hand, the cosmetics available for alleviating stretch marks containing nanoliposomalized glycolic acid according to the present invention can be composed of any one of a skin preparation, a gel preparation, a rosewater and a cream preparation. That is, according to the present invention, it can be formulated into a cosmetic for applying a skin such as a skin preparation, a gel, a rooient, a cream, etc., and various concentrations of nanoliposomalized glycolic acid can be used according to a desired formulation.

The skin agent comprises 0.050 to 2.000% by weight of nanoliposomalated glycolic acid in the composition of 0.100 to 20.000% by weight of glycolic acid, 0.100 to 5.000% by weight of ceramide, 0.100 to 5.000% by weight of cholesterol and 0.100 to 5.000% by weight of fatty acid, 0.050 ~ 2.000% by weight of extracts, 0.050 ~ 2.000% by weight of extracts, 0.050 ~ 2.000% by weight of extracts of locusts, 0.050 ~ 2.000% by weight of green tea extracts and other surfactants, moisturizers and preservatives.

Wherein the gelatin is 0.050 to 2.000 wt% of nanoliposomalized glycolic acid, 0.100 to 5.000 wt% of allantoin, 0.100 to 20.000 wt% of glycolic acid, 0.100 to 5.000 wt% of ceramide, 0.100 to 5.000 wt% of cholesterol, 0.050 ~ 2.000 wt.% Of mashin extract, 0.050 ~ 2.000 wt.% Of positional hazel extract, 0.050 ~ 2.000 wt.% Of green tea extract, and other thickeners, surfactants, moisturizers and preservatives can be selectively used and the remainder is composed of purified water .

Wherein the ointment agent comprises 0.050 to 2.000 wt.% Of nanoliposomalated glycolic acid composed of 0.100 to 20.000 wt.% Of glycolic acid, 0.100 to 5.000 wt.% Of ceramide, 0.100 to 5.000 wt.% Of cholesterol and 0.100 to 5.000 wt.% Of fatty acid, A vegetable oil, a silicone oil, a higher fatty acid and an ester, a surfactant, a surfactant, a surfactant, a surfactant, an antioxidant, an antioxidant, an antioxidant, Moisturizer and preservative can be used selectively, and the remainder is composed of purified water.

The cream preparation contains 0.050 to 2.000% by weight of nanoliposomized crystallic acid composed of 0.100 to 20.000% by weight of glycolic acid, 0.100 to 5.000% by weight of ceramide, 0.100 to 5.000% by weight of cholesterol and 0.100 to 5.000% by weight of fatty acid, 5.000% by weight of the extract, 0.050% to 2.000% by weight of the extract of marjoram, 0.050 to 2.000% by weight of the extract of oriental jelly, 0.050 to 2.000% by weight of the green tea extract, vegetable oils, vegetable oils, silicone oil, higher fatty acids and esters, , Preservatives can be used selectively, and the remainder is composed of purified water.

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in more detail with reference to examples of cosmetics which are effective for relaxation of stretch marks containing nanoliposomized glycolic acid according to the present invention.

[Example 1]

1. Preparation of Nano-Liposome Glycolic Acid

Nanoliposomal glycolic acid was prepared by the ingredients and ratios shown in Table 1 below.

Compounding ingredient Blending ratio (% by weight) Purified water To 100 lecithin 10,000 to 50,000 Fatty acid ester 1.000 ~ 10.000 Ceramide 0.100 to 5.000 cholesterol 0.100 to 5.000 fatty acid 0.100 to 5.000 Glycolic acid 0.100 to 20,000 vegetable oil 1.000 ~ 5.000 Vitamin E derivative 0.010 to 1.000

2. As an example of a cosmetic composition effective for alleviating stretch marks containing the nanoliposomalized glycolic acid according to the present invention using the nanoliposome glycolic acid (hereinafter, referred to as " nano GCA ") prepared as described above, Creams were prepared according to the ingredients and ratios in Table 2.

Compounding ingredient Blending ratio (% by weight) Purified water To 100 Fatty acid ester 1.000 ~ 10.000 Glycol 0.500 ~ 5.000 silicon 0.100 to 2.000 Monoester 0.100 to 2.000 Vitamin derivative 0.010 to 1.000 Nano GCA * 0.050 to 2.000 Allantoin 0.100 to 5.000 Marchia extract 0.050 to 2.000 Location of Hazel extract 0.050 to 2.000 Tea tea weight 0.050 to 2.000 High moisture polymer 0.100 to 5.000 Polysorbate 0.100 to 5.000

[ Test Example  One] Stretch  Improvement effect, satisfaction of skin elasticity, satisfaction of moisturizing sustainability evaluation

- Questionnaire: 100 women in their 20s and 40s who completed breastfeeding period after giving birth

- Test method: In the morning / evening, after applying the massage to the area where the stomach is formed such as the stomach and thigh, after 4 weeks use survey

- Questionnaire contents: Effect of improvement of stretch marks, satisfaction of skin elasticity, satisfaction of moisturizing sustainability

Results: As shown in the graph showing the effect of improving the stretch marks of Example 1 of the cosmetic composition effective for relaxation of stretch marks containing nanoliposomalized glycolic acid according to the present invention shown in FIG. 3, about 85% or more Fig. 4 is a graph showing the satisfaction of skin elasticity with respect to Example 1 of a cosmetic useful for relaxation of stretch marks containing nanoliposomalized glycolic acid according to the present invention. As can be seen in the graph, about 90% or more of the subjects of the questionnaire were satisfied with the satisfaction of the skin elasticity, satisfaction and generally satisfied, and Figure 5 shows that the nanoliposomized glycolic acid- In the graph showing the satisfaction of the moisturizing sustainability of Example 1 of cosmetics available for stretch release, As can be seen, about 85% or more of the questionnaires were satisfied with satisfactory, satisfactory and generally satisfactory satisfaction of the moisturizing sustainability.

[Test Example 2] Comparative test of the preference of Example 1 and Comparative Example 1

In this test, nano-liposomized glycolic acid according to Example 1 of the present invention which is useful for relaxation of stretch marks containing nanoliposomalized glycolic acid according to the present invention and nanoliposomalized glycolic acid ([Table 2] Nano GCA ') was replaced by a conventional glycolic acid, the cream prepared in the same manner as in Example 1 was evaluated as Comparative Example 1, and the relative preference was evaluated.

Compounding ingredient Blending ratio (% by weight) Purified water To 100 Fatty acid ester 1.000 ~ 10.000 Glycol 0.500 ~ 5.000 silicon 0.100 to 2.000 Monoester 0.100 to 2.000 Vitamin derivative 0.010 to 1.000 Glycolic Acid 0.001 to 0.500 Allantoin 0.100 to 5.000 Marchia extract 0.050 to 2.000 Location of Hazel extract 0.050 to 2.000 Tea tea weight 0.050 to 2.000 High moisture polymer 0.100 to 5.000 Polysorbate 0.100 to 5.000

- Questionnaire: 100 women in their 20s and 40s who completed breastfeeding period after giving birth

- Test method: Apply for 4 weeks in the morning and evening after applying to the thigh with stretch marks. For the left thigh, use the cream of Example 1 and the right thigh with the same symptoms as the stretch on the left thigh. The cream of Comparative Example 1 was applied to the stretch marks of the region,

- Questionnaire contents: Reason for selection and selection of preferred embodiment 1 and comparative example 1

Results: As can be seen from the graph showing the preference for the cosmetic material effective for the stretch-relaxation containing the nanoliposomized glycolic acid according to the present invention of Example 1 and Comparative Example 1 of Fig. 6, 72% preferred to use Example 1 and 5.5% more preferred than 13% who preferred to use Comparative Example 1. The reason for selecting Example 1 was that there was no irritation, moisturizing power was maintained longer than Comparative Example 1, and in particular, a white line appeared to be white and the boundary was softened. On the other hand, The skin was smooth and smooth.

The subject to be tested of Comparative Example 1 was selected to have a feeling of simplicity rather than efficacy of the stretch-reducing effect of Example 1. In contrast to Example 1, Comparative Example 1 contained a glycolic acid prototype other than liposomized glycolic acid, The low viscosity can make the feeling feel smooth and the skin can be temporarily smoothed because the exfoliation is improved more.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the invention. Therefore, it is to be understood that the present invention is not limited to the above-described embodiments. Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims. It is also to be understood that the invention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the appended claims.

Claims (7)

Which comprises nanoliposomalated glycolic acid as an active ingredient,
The nano liposomized glycolic acid may be,
A cosmetic useful for alleviating stretch marks containing nanoliposomalated glycolic acid, characterized in that it contains 0.05 to 2% by weight, based on the total weight, of glycolic acid mixed with ceramide, cholesterol and fatty acid to form nanoliposomes.
delete delete The method according to claim 1,
The nano liposomized glycolic acid may be,
0.1 to 5 parts by weight of said ceramide, 0.1 to 5 parts by weight of said cholesterol and 0.1 to 5 parts by weight of said fatty acid are blended with 0.1 to 20 parts by weight of said glycolic acid to form nanoliposomalized glycolic acid. Cosmetics available for stretch relaxation.
The method according to claim 1,
Wherein the composition further comprises at least one selected from the group consisting of alginic acid, allantoin, hyaluronic acid extract, locust hyaluronic acid extract and green tea extract, which is effective for alleviating stretch marks containing nanoliposomalized glycolic acid.
6. The method of claim 5,
Wherein 0.05 to 2 parts by weight of the allantoin extract, 0.05 to 2 parts by weight of the hatchery extract, 0.05 to 2 parts by weight of the hatchery extract and 0.05 to 2 parts by weight of the green tea extract are contained in 0.05 to 2 parts by weight of the nanoliposomalized To 2 parts by weight of a nanoliposomalized glycolic acid.
The method according to any one of claims 1 to 5,
A cosmetic useful for alleviating stretch marks containing nanoliposomalized glycolic acid, wherein the cosmetic composition is any one of a skin preparation, a gel preparation, a rosewater, and a cream preparation.

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