KR20080016890A - 티게사이클린의 결정 고체 형태 및 이의 제조 방법 - Google Patents

티게사이클린의 결정 고체 형태 및 이의 제조 방법 Download PDF

Info

Publication number
KR20080016890A
KR20080016890A KR1020077030562A KR20077030562A KR20080016890A KR 20080016890 A KR20080016890 A KR 20080016890A KR 1020077030562 A KR1020077030562 A KR 1020077030562A KR 20077030562 A KR20077030562 A KR 20077030562A KR 20080016890 A KR20080016890 A KR 20080016890A
Authority
KR
South Korea
Prior art keywords
tigecycline
type
powder diffraction
ray powder
suitable solvent
Prior art date
Application number
KR1020077030562A
Other languages
English (en)
Korean (ko)
Inventor
라리타 크리쉬난
수보드 에스. 데쉬무크
안토니 하드필드
제임스 더블유. 후앙
맨칭 쉐리 쿠
Original Assignee
와이어쓰
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37026996&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20080016890(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 와이어쓰 filed Critical 와이어쓰
Publication of KR20080016890A publication Critical patent/KR20080016890A/ko

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
KR1020077030562A 2005-05-27 2006-05-25 티게사이클린의 결정 고체 형태 및 이의 제조 방법 KR20080016890A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68495505P 2005-05-27 2005-05-27
US60/684,955 2005-05-27

Publications (1)

Publication Number Publication Date
KR20080016890A true KR20080016890A (ko) 2008-02-22

Family

ID=37026996

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077030562A KR20080016890A (ko) 2005-05-27 2006-05-25 티게사이클린의 결정 고체 형태 및 이의 제조 방법

Country Status (28)

Country Link
US (1) US8372995B2 (sl)
EP (1) EP1890996B1 (sl)
JP (2) JP2008545717A (sl)
KR (1) KR20080016890A (sl)
CN (1) CN101248038B (sl)
AR (1) AR057649A1 (sl)
AU (1) AU2006251954A1 (sl)
BR (1) BRPI0610653A2 (sl)
CA (1) CA2609875C (sl)
CL (1) CL2006001266A1 (sl)
CR (1) CR9540A (sl)
DK (1) DK1890996T3 (sl)
EC (1) ECSP078055A (sl)
ES (1) ES2415518T3 (sl)
GT (1) GT200600227A (sl)
HK (1) HK1113786A1 (sl)
IL (1) IL187359A (sl)
MX (1) MX2007014735A (sl)
NO (1) NO20076005L (sl)
PE (1) PE20070024A1 (sl)
PL (1) PL1890996T3 (sl)
PT (1) PT1890996E (sl)
RU (1) RU2478612C2 (sl)
SI (1) SI1890996T1 (sl)
SV (1) SV2008002542A (sl)
TW (1) TWI421232B (sl)
WO (1) WO2006128150A2 (sl)
ZA (1) ZA200710151B (sl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007120913A2 (en) * 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
EP2016045B1 (en) 2006-04-24 2014-10-29 Teva Pharmaceutical Industries, Ltd. A tigecycline crystalline form and processes for its preparation
EP2236491A3 (en) 2006-11-29 2010-11-03 Teva Pharmaceutical Industries, Ltd. Crystalline form of tigecycline and processes for preparation thereof
BRPI0706517A2 (pt) * 2006-11-30 2011-03-29 Teva Pharma processos para preparação de f 9-haloacetamidominociclinas
PT103661B (pt) * 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
AT13157U1 (de) * 2007-04-24 2013-07-15 Teva Pharma Tigecyclin, kristalline Formen und Herstellungsverfahren dafür
WO2008155405A1 (en) 2007-06-21 2008-12-24 Sandoz Ag Crystalline solid forms
EP2220032A1 (en) * 2007-11-14 2010-08-25 Sandoz AG Novel solvate
CN101861300B (zh) * 2007-11-14 2014-07-09 桑多斯股份公司 盐酸替吉环素的晶型
WO2009070799A1 (en) * 2007-11-29 2009-06-04 Teva Pharmaceutical Industries Ltd. Processes for preparation of crystalline tigecycline form ii
WO2009092680A2 (en) * 2008-01-23 2009-07-30 Sandoz Ag Antibiotic compounds
ITMI20080807A1 (it) 2008-05-05 2009-11-06 Antibioticos Spa Procedimento per la preparazione di tigeciclina in forma amorfa
TW202332671A (zh) * 2008-05-23 2023-08-16 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
WO2010070093A1 (en) 2008-12-18 2010-06-24 Sandoz Ag Crystalline form c of tigecycline dihydrochloride and methods for its preparation
PT104350A (pt) 2009-01-23 2010-07-23 Hovione Farmaci Ncia S A Processo de isolamento de tigeciclina
CN102746183B (zh) 2011-04-20 2014-12-17 胡梨芳 替加环素结晶水合物及其制备方法和用途
CN102295576A (zh) * 2011-06-29 2011-12-28 赵军旭 替加环素的晶型及其制备方法
CN102898325B (zh) * 2011-07-29 2015-07-08 江苏奥赛康药业股份有限公司 替加环素晶体及其制备方法
CN102924322B (zh) * 2012-11-05 2014-09-17 赵军旭 一种替加环素的新晶型及其制备方法
CN103833590A (zh) * 2012-11-26 2014-06-04 石药集团中奇制药技术（石家庄）有限公司 替加环素晶型及其制备方法
CN109563035B (zh) * 2016-06-22 2021-07-20 山东亨利医药科技有限责任公司 9-氨基甲基取代的四环素类化合物的晶型及其制备方法
US11492342B2 (en) 2020-11-03 2022-11-08 Landos Biopharma, Inc. Crystalline forms of piperazine-1,4-diylbis((6-(1H-benzo[d]imidazo-2-yl)pyridin-2yl)methanone)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2168254T3 (es) 1991-10-04 2002-06-16 American Cyanamid Co Nuevas 7-sustituidas-9-(amino sustituido)-6-desmetil-6-desoxitetraciclinas.
US5284963A (en) 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
SG47520A1 (en) 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5328902A (en) 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5420272A (en) 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
US20020048610A1 (en) * 2000-01-07 2002-04-25 Cima Michael J. High-throughput formation, identification, and analysis of diverse solid-forms
PE20061107A1 (es) * 2005-03-14 2006-12-08 Wyeth Corp Composiciones de tigeciclina y metodos para su preparacion
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion

Also Published As

Publication number Publication date
CN101248038B (zh) 2014-03-05
US8372995B2 (en) 2013-02-12
GT200600227A (es) 2007-01-12
CA2609875A1 (en) 2006-11-30
SI1890996T1 (sl) 2013-06-28
HK1113786A1 (en) 2008-10-17
EP1890996A2 (en) 2008-02-27
EP1890996B1 (en) 2013-04-24
NO20076005L (no) 2008-02-22
AU2006251954A1 (en) 2006-11-30
CA2609875C (en) 2014-01-07
BRPI0610653A2 (pt) 2010-07-13
IL187359A0 (en) 2008-04-13
RU2007143160A (ru) 2009-07-10
SV2008002542A (es) 2008-02-22
PE20070024A1 (es) 2007-02-06
CR9540A (es) 2008-02-21
CN101248038A (zh) 2008-08-20
WO2006128150A2 (en) 2006-11-30
TW200720232A (en) 2007-06-01
PL1890996T3 (pl) 2013-08-30
JP2008545717A (ja) 2008-12-18
PT1890996E (pt) 2013-06-24
CL2006001266A1 (es) 2008-05-16
WO2006128150A3 (en) 2007-03-08
AR057649A1 (es) 2007-12-12
US20070123497A1 (en) 2007-05-31
RU2478612C2 (ru) 2013-04-10
MX2007014735A (es) 2008-02-15
IL187359A (en) 2013-04-30
DK1890996T3 (da) 2013-05-13
JP2013100354A (ja) 2013-05-23
ES2415518T3 (es) 2013-07-25
ZA200710151B (en) 2010-05-26
TWI421232B (zh) 2014-01-01
ECSP078055A (es) 2008-01-23

Similar Documents

Publication Publication Date Title
KR20080016890A (ko) 티게사이클린의 결정 고체 형태 및 이의 제조 방법
WO2017008773A1 (en) Crystalline forms of obeticholic acid
WO2020232325A1 (en) Solid state forms of tafamidis and salts thereof
US20100160264A1 (en) Crystalline solid forms
WO2020185812A1 (en) Solid state forms of ripretinib
US20110124893A1 (en) Antibiotic compounds
US20160168166A1 (en) A process for preparing rifaximin k
IL265180A (en) New polymorphs and new solid states of thiacomycin b
ES2773502T3 (es) Nuevo polimorfo de clorhidrato de ivabradina y método para su preparación
JP2013510098A (ja) 特定の結晶性水和物、その医薬組成物、ならびにその調製方法および使用方法
WO2021237004A1 (en) Solid state forms of aprocitentan and process for preparation thereof
EP4034256A1 (en) Solid state forms of lucerastat salts and process for preparation thereof
WO2019130354A1 (en) Polymorphic forms of (9-[(r)-2-[[(s)-[[(s)-1- (isopropoxycarbonyl)ethyl]amino]phenoxy phosphinyl]methoxy]propyl] adenine and pharmaceutically acceptable salts thereof
EP2220032A1 (en) Novel solvate
WO2023096954A9 (en) Solid state forms of nirogacestat salts
EP4188922A1 (en) Solid state forms of ensartinib and ensartinib salts
Joshi et al. Solid-state characterization of thiocolchicoside
WO2024069574A1 (en) Solid state forms of denifanstat
CZ20001404A3 (cs) Nové polymorfní formy cipamfylinu

Legal Events

Date Code Title Description
SUBM Surrender of laid-open application requested