KR20070106767A - 바이러스 감염을 치료하기 위한 트리시클릭-뉴클레오시드화합물 - Google Patents

바이러스 감염을 치료하기 위한 트리시클릭-뉴클레오시드화합물 Download PDF

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Publication number
KR20070106767A
KR20070106767A KR1020077020680A KR20077020680A KR20070106767A KR 20070106767 A KR20070106767 A KR 20070106767A KR 1020077020680 A KR1020077020680 A KR 1020077020680A KR 20077020680 A KR20077020680 A KR 20077020680A KR 20070106767 A KR20070106767 A KR 20070106767A
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KR
South Korea
Prior art keywords
methyl
ribofuranosyl
benzo
dihydro
group
Prior art date
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Withdrawn
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KR1020077020680A
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English (en)
Korean (ko)
Inventor
제쎄 디 케이처
크리스토퍼 돈 로버츠
세바스티안 요하네스 라인하르트 리에르
샤오링 쳉
마리야 프르하브크
비벡 쿠마르 라즈완시
로날드 콘래드 그리피스
김정우
Original Assignee
제네랩스 테크놀로지스, 인코포레이티드
길리애드 사이언시즈, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 제네랩스 테크놀로지스, 인코포레이티드, 길리애드 사이언시즈, 인코포레이티드 filed Critical 제네랩스 테크놀로지스, 인코포레이티드
Publication of KR20070106767A publication Critical patent/KR20070106767A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/22—Pteridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020077020680A 2005-02-28 2006-02-28 바이러스 감염을 치료하기 위한 트리시클릭-뉴클레오시드화합물 Withdrawn KR20070106767A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65746305P 2005-02-28 2005-02-28
US60/657,463 2005-02-28

Publications (1)

Publication Number Publication Date
KR20070106767A true KR20070106767A (ko) 2007-11-05

Family

ID=36570903

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020077020680A Withdrawn KR20070106767A (ko) 2005-02-28 2006-02-28 바이러스 감염을 치료하기 위한 트리시클릭-뉴클레오시드화합물
KR1020077021265A Withdrawn KR20070106781A (ko) 2005-02-28 2006-02-28 바이러스 감염을 치료하기 위한 트리시클릭-뉴클레오시드프로드러그

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020077021265A Withdrawn KR20070106781A (ko) 2005-02-28 2006-02-28 바이러스 감염을 치료하기 위한 트리시클릭-뉴클레오시드프로드러그

Country Status (18)

Country Link
US (4) US7524825B2 (https=)
EP (2) EP1853618A1 (https=)
JP (2) JP2008531704A (https=)
KR (2) KR20070106767A (https=)
CN (2) CN101142226A (https=)
AP (2) AP2007004128A0 (https=)
AR (1) AR058419A1 (https=)
AU (2) AU2006218705A1 (https=)
BR (2) BRPI0607770A2 (https=)
CA (2) CA2597685A1 (https=)
EA (2) EA200701849A1 (https=)
HR (2) HRP20070436A2 (https=)
IL (2) IL184954A0 (https=)
MX (2) MX2007010460A (https=)
NO (2) NO20074613L (https=)
TW (1) TW200640474A (https=)
WO (2) WO2006093986A1 (https=)
ZA (1) ZA200707410B (https=)

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Also Published As

Publication number Publication date
EA200701849A1 (ru) 2008-02-28
EA200701850A1 (ru) 2008-02-28
US20060194749A1 (en) 2006-08-31
JP2008531703A (ja) 2008-08-14
EP1853618A1 (en) 2007-11-14
US20090253648A1 (en) 2009-10-08
AP2007004118A0 (en) 2007-08-31
WO2006093986A1 (en) 2006-09-08
ZA200707410B (en) 2008-10-29
MX2007010460A (es) 2007-11-08
TW200640474A (en) 2006-12-01
WO2006093987A1 (en) 2006-09-08
NO20074915L (no) 2007-11-20
AP2007004128A0 (en) 2007-08-31
AR058419A1 (es) 2008-02-06
NO20074613L (no) 2007-11-27
CN101142226A (zh) 2008-03-12
CN101128474A (zh) 2008-02-20
JP2008531704A (ja) 2008-08-14
MX2007010463A (es) 2007-11-08
US7534771B2 (en) 2009-05-19
IL184954A0 (en) 2007-12-03
CA2597683A1 (en) 2006-09-08
CA2597685A1 (en) 2006-09-08
HRP20070436A2 (hr) 2008-02-29
HRP20070435A9 (en) 2008-09-30
EP1853617A1 (en) 2007-11-14
HRP20070435A2 (hr) 2008-02-29
BRPI0607769A2 (pt) 2009-10-06
US20090208457A1 (en) 2009-08-20
IL184955A0 (en) 2007-12-03
KR20070106781A (ko) 2007-11-05
BRPI0607770A2 (pt) 2009-06-13
AU2006218705A1 (en) 2006-09-08
US20060252715A1 (en) 2006-11-09
AU2006218704A1 (en) 2006-09-08
US7524825B2 (en) 2009-04-28

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