KR20070100875A - 약학 조성물 및 아르기나제로 간염을 치료하는 방법 - Google Patents
약학 조성물 및 아르기나제로 간염을 치료하는 방법 Download PDFInfo
- Publication number
- KR20070100875A KR20070100875A KR1020077007829A KR20077007829A KR20070100875A KR 20070100875 A KR20070100875 A KR 20070100875A KR 1020077007829 A KR1020077007829 A KR 1020077007829A KR 20077007829 A KR20077007829 A KR 20077007829A KR 20070100875 A KR20070100875 A KR 20070100875A
- Authority
- KR
- South Korea
- Prior art keywords
- arginase
- enzyme
- pharmaceutical composition
- gly
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 102000004452 Arginase Human genes 0.000 title claims description 74
- 108700024123 Arginases Proteins 0.000 title claims description 74
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 32
- 208000006454 hepatitis Diseases 0.000 title claims description 12
- 231100000283 hepatitis Toxicity 0.000 title claims description 12
- 239000003814 drug Substances 0.000 claims abstract description 32
- 101000752037 Homo sapiens Arginase-1 Proteins 0.000 claims abstract description 12
- 102000053089 human ARG1 Human genes 0.000 claims abstract description 12
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 102000004190 Enzymes Human genes 0.000 claims description 29
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- 239000004475 Arginine Substances 0.000 claims description 15
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- 230000000694 effects Effects 0.000 claims description 14
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100768544A CN1745847A (zh) | 2004-09-08 | 2004-09-08 | 用精氨酸酶治疗肝炎的药物组合物和方法 |
| CN200410076854.4 | 2004-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20070100875A true KR20070100875A (ko) | 2007-10-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077007829A Withdrawn KR20070100875A (ko) | 2004-09-08 | 2005-09-06 | 약학 조성물 및 아르기나제로 간염을 치료하는 방법 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080299638A1 (https=) |
| EP (1) | EP1803465A4 (https=) |
| JP (1) | JP2008512399A (https=) |
| KR (1) | KR20070100875A (https=) |
| CN (1) | CN1745847A (https=) |
| WO (1) | WO2006026915A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3778885T (pt) * | 2008-10-31 | 2023-05-31 | Aerase Inc | Composições de arginases humanas modificadas e métodos para o tratamento do cancro |
| CA2756442C (en) | 2009-03-26 | 2016-03-29 | The Hong Kong Polytechnic University | Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents |
| CN103184209B (zh) * | 2011-12-27 | 2015-09-16 | 拜奥生物科技（上海）有限公司 | 人精氨酸酶和聚乙二醇化人精氨酸酶及其应用 |
| ES2897635T3 (es) * | 2014-04-29 | 2022-03-02 | Bio Cancer Treat International Ltd | Métodos y composiciones para modular el sistema inmunológico con la arginasa I |
| GB2568000A (en) | 2016-08-08 | 2019-05-01 | Aerase Inc | Compositions and methods for treating cancer with arginine depletion and immuno oncology agents |
| US11717562B2 (en) | 2017-12-05 | 2023-08-08 | Aerase, Inc. | Method and composition for treating arginase 1 deficiency |
| CA3116736A1 (en) | 2018-10-19 | 2020-04-23 | Aerase, Inc. | Arginine depletion therapy for treatment of gamt deficiency |
| CN114729344A (zh) | 2019-08-30 | 2022-07-08 | 安格利亚生物制药公司 | 人重组精氨酸酶1的生产方法及其用途 |
| CA3180529A1 (en) * | 2020-04-17 | 2021-10-21 | Bio-Cancer Treatment International Limited | Methods of treating viral infections using arginase |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1059127C (zh) * | 1995-07-19 | 2000-12-06 | 郝文学 | 治疗肝病的药物“疏肝酶”的制法 |
| US5780286A (en) * | 1996-03-14 | 1998-07-14 | Smithkline Beecham Corporation | Arginase II |
| US5851985A (en) * | 1996-08-16 | 1998-12-22 | Tepic; Slobodan | Treatment of tumors by arginine deprivation |
| US6183738B1 (en) * | 1997-05-12 | 2001-02-06 | Phoenix Pharamacologics, Inc. | Modified arginine deiminase |
| WO2004000349A1 (en) * | 2002-06-20 | 2003-12-31 | Bio-Cancer Treatment International Limited | Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation |
| HK1053577A2 (en) * | 2002-06-20 | 2003-10-10 | Bio-Cancer Treatment International Limited | Pharmaceutical composition and method of treatment of human malignanices with arginine deprivation |
-
2004
- 2004-09-08 CN CNA2004100768544A patent/CN1745847A/zh active Pending
-
2005
- 2005-09-06 KR KR1020077007829A patent/KR20070100875A/ko not_active Withdrawn
- 2005-09-06 EP EP05783950A patent/EP1803465A4/en not_active Withdrawn
- 2005-09-06 JP JP2007530572A patent/JP2008512399A/ja active Pending
- 2005-09-06 WO PCT/CN2005/001411 patent/WO2006026915A1/zh not_active Ceased
-
2007
- 2007-03-01 US US11/680,631 patent/US20080299638A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008512399A (ja) | 2008-04-24 |
| CN1745847A (zh) | 2006-03-15 |
| EP1803465A1 (en) | 2007-07-04 |
| EP1803465A4 (en) | 2009-08-12 |
| WO2006026915A1 (fr) | 2006-03-16 |
| US20080299638A1 (en) | 2008-12-04 |
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Patent event date: 20070405 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |