KR20070100875A - 약학 조성물 및 아르기나제로 간염을 치료하는 방법 - Google Patents
약학 조성물 및 아르기나제로 간염을 치료하는 방법 Download PDFInfo
- Publication number
- KR20070100875A KR20070100875A KR1020077007829A KR20077007829A KR20070100875A KR 20070100875 A KR20070100875 A KR 20070100875A KR 1020077007829 A KR1020077007829 A KR 1020077007829A KR 20077007829 A KR20077007829 A KR 20077007829A KR 20070100875 A KR20070100875 A KR 20070100875A
- Authority
- KR
- South Korea
- Prior art keywords
- arginase
- enzyme
- pharmaceutical composition
- gly
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 102000004452 Arginase Human genes 0.000 title claims description 74
- 108700024123 Arginases Proteins 0.000 title claims description 74
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 32
- 208000006454 hepatitis Diseases 0.000 title claims description 12
- 231100000283 hepatitis Toxicity 0.000 title claims description 12
- 239000003814 drug Substances 0.000 claims abstract description 32
- 101000752037 Homo sapiens Arginase-1 Proteins 0.000 claims abstract description 12
- 102000053089 human ARG1 Human genes 0.000 claims abstract description 12
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 102000004190 Enzymes Human genes 0.000 claims description 29
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- 239000004475 Arginine Substances 0.000 claims description 15
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- 230000000694 effects Effects 0.000 claims description 14
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 5
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200410076854.4 | 2004-09-08 | ||
| CNA2004100768544A CN1745847A (zh) | 2004-09-08 | 2004-09-08 | 用精氨酸酶治疗肝炎的药物组合物和方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20070100875A true KR20070100875A (ko) | 2007-10-12 |
Family
ID=36036072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077007829A Withdrawn KR20070100875A (ko) | 2004-09-08 | 2005-09-06 | 약학 조성물 및 아르기나제로 간염을 치료하는 방법 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080299638A1 (https=) |
| EP (1) | EP1803465A4 (https=) |
| JP (1) | JP2008512399A (https=) |
| KR (1) | KR20070100875A (https=) |
| CN (1) | CN1745847A (https=) |
| WO (1) | WO2006026915A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2742497C (en) * | 2008-10-31 | 2024-01-23 | George Georgiou | Compositions of engineered human arginases and methods for treating cancer |
| AU2010242422B2 (en) * | 2009-03-26 | 2014-12-04 | The Hong Kong Polytechnic University | Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents |
| CN103184208B (zh) * | 2011-12-27 | 2015-09-16 | 拜奥生物科技（上海）有限公司 | 人精氨酸酶和定点聚乙二醇化人精氨酸酶及其应用 |
| CN106456723B (zh) * | 2014-04-29 | 2021-03-09 | 康达医药科技有限公司 | 采用精氨酸酶i调节免疫系统的方法和组合物 |
| GB2568000A (en) | 2016-08-08 | 2019-05-01 | Aerase Inc | Compositions and methods for treating cancer with arginine depletion and immuno oncology agents |
| CN120661640A (zh) | 2017-12-05 | 2025-09-19 | 伊梅尔迪卡制药公司 | 用于治疗精氨酸酶1缺乏症的方法和组合物 |
| WO2020081994A1 (en) | 2018-10-19 | 2020-04-23 | Aerase, Inc. | Arginine depletion therapy for treatment of gamt deficiency |
| KR20220082813A (ko) | 2019-08-30 | 2022-06-17 | 아이글레아 바이오테라퓨틱스, 인크. | 인간 재조합 아르기나아제 1의 제조 방법 및 이의 사용 |
| JP2023522888A (ja) * | 2020-04-17 | 2023-06-01 | バイオ－キャンサー・トリートメント・インターナショナル・リミテッド | アルギナーゼを使用してウイルス感染症を処置する方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1059127C (zh) * | 1995-07-19 | 2000-12-06 | 郝文学 | 治疗肝病的药物“疏肝酶”的制法 |
| US5780286A (en) * | 1996-03-14 | 1998-07-14 | Smithkline Beecham Corporation | Arginase II |
| US5851985A (en) * | 1996-08-16 | 1998-12-22 | Tepic; Slobodan | Treatment of tumors by arginine deprivation |
| US6183738B1 (en) * | 1997-05-12 | 2001-02-06 | Phoenix Pharamacologics, Inc. | Modified arginine deiminase |
| JP2005538709A (ja) * | 2002-06-20 | 2005-12-22 | バイオ−キャンサー・トリートメント・インターナショナル・リミテッド | アルギニンを欠乏させることによってヒト悪性腫瘍を治療する医薬品及び方法 |
| HK1053577A2 (en) * | 2002-06-20 | 2003-10-10 | Bio-Cancer Treatment International Limited | Pharmaceutical composition and method of treatment of human malignanices with arginine deprivation |
-
2004
- 2004-09-08 CN CNA2004100768544A patent/CN1745847A/zh active Pending
-
2005
- 2005-09-06 EP EP05783950A patent/EP1803465A4/en not_active Withdrawn
- 2005-09-06 WO PCT/CN2005/001411 patent/WO2006026915A1/zh not_active Ceased
- 2005-09-06 JP JP2007530572A patent/JP2008512399A/ja active Pending
- 2005-09-06 KR KR1020077007829A patent/KR20070100875A/ko not_active Withdrawn
-
2007
- 2007-03-01 US US11/680,631 patent/US20080299638A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1803465A4 (en) | 2009-08-12 |
| JP2008512399A (ja) | 2008-04-24 |
| CN1745847A (zh) | 2006-03-15 |
| WO2006026915A1 (fr) | 2006-03-16 |
| EP1803465A1 (en) | 2007-07-04 |
| US20080299638A1 (en) | 2008-12-04 |
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| PA0105 | International application |
Patent event date: 20070405 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |