KR20070072924A - 화학적으로 개질된 인간 성장 호르몬 콘쥬게이트 - Google Patents

화학적으로 개질된 인간 성장 호르몬 콘쥬게이트 Download PDF

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Publication number
KR20070072924A
KR20070072924A KR1020077011730A KR20077011730A KR20070072924A KR 20070072924 A KR20070072924 A KR 20070072924A KR 1020077011730 A KR1020077011730 A KR 1020077011730A KR 20077011730 A KR20077011730 A KR 20077011730A KR 20070072924 A KR20070072924 A KR 20070072924A
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KR
South Korea
Prior art keywords
hgh
peg
poly
ethylene glycol
growth hormone
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KR1020077011730A
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English (en)
Korean (ko)
Inventor
로리 에프. 핀
웨이 라오
네드 알. 시겔
Original Assignee
파마시아 코포레이션
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Application filed by 파마시아 코포레이션 filed Critical 파마시아 코포레이션
Publication of KR20070072924A publication Critical patent/KR20070072924A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
KR1020077011730A 2001-11-20 2002-11-20 화학적으로 개질된 인간 성장 호르몬 콘쥬게이트 KR20070072924A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33190701P 2001-11-20 2001-11-20
US60/331,907 2001-11-20

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020047007708A Division KR20050044858A (ko) 2001-11-20 2002-11-20 화학적으로 개질된 인간 성장 호르몬 콘쥬게이트

Publications (1)

Publication Number Publication Date
KR20070072924A true KR20070072924A (ko) 2007-07-06

Family

ID=23295870

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020077011730A KR20070072924A (ko) 2001-11-20 2002-11-20 화학적으로 개질된 인간 성장 호르몬 콘쥬게이트
KR1020047007708A KR20050044858A (ko) 2001-11-20 2002-11-20 화학적으로 개질된 인간 성장 호르몬 콘쥬게이트

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020047007708A KR20050044858A (ko) 2001-11-20 2002-11-20 화학적으로 개질된 인간 성장 호르몬 콘쥬게이트

Country Status (25)

Country Link
EP (1) EP1453859A2 (hr)
JP (2) JP2005525302A (hr)
KR (2) KR20070072924A (hr)
CN (1) CN1608079A (hr)
AP (1) AP2004003050A0 (hr)
AU (1) AU2002356990A1 (hr)
BR (1) BR0214451A (hr)
CA (1) CA2467731A1 (hr)
CO (1) CO5580794A2 (hr)
EA (2) EA200700431A1 (hr)
EC (1) ECSP045114A (hr)
GE (1) GEP20063860B (hr)
HR (1) HRP20040448A2 (hr)
HU (1) HUP0500997A2 (hr)
IL (1) IL162031A0 (hr)
IS (1) IS7268A (hr)
MA (1) MA27544A1 (hr)
MX (1) MXPA04004809A (hr)
NO (1) NO20042182L (hr)
OA (1) OA13063A (hr)
PL (1) PL374354A1 (hr)
RS (1) RS53104A (hr)
TN (1) TNSN04090A1 (hr)
WO (1) WO2003044056A2 (hr)
ZA (1) ZA200403907B (hr)

Cited By (1)

* Cited by examiner, † Cited by third party
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KR101104574B1 (ko) * 2008-05-14 2012-01-11 성균관대학교산학협력단 폴리에틸렌글리콜로 화학적으로 수식된 인간 성장 호르몬, 이의 제조방법 및 용도

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EP1546235B1 (en) 2002-09-09 2021-10-20 Nektar Therapeutics Water-soluble polymer alkanals
US20040142870A1 (en) * 2002-11-20 2004-07-22 Finn Rory F. N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof
US20050281778A1 (en) * 2003-03-28 2005-12-22 Myung-Ok Park Human growth hormone conjugated with biocompatible polymer
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US7524813B2 (en) 2003-10-10 2009-04-28 Novo Nordisk Health Care Ag Selectively conjugated peptides and methods of making the same
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CN103690936A (zh) 2004-12-22 2014-04-02 Ambrx公司 经修饰的人类生长激素
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US20080317670A1 (en) 2005-12-14 2008-12-25 Ambrx, Inc. Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides
WO2008003750A2 (en) * 2006-07-07 2008-01-10 Novo Nordisk Health Care Ag New protein conjugates and methods for their preparation
CN101108895B (zh) * 2006-07-19 2011-10-26 北京键凯科技有限公司 聚乙二醇乙醛衍生物及其与药物的结合物
AU2007310777A1 (en) 2006-10-26 2008-05-02 Novo Nordisk A/S IL-21 variants
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AU2008353850B2 (en) * 2008-04-03 2014-08-21 Biosteed Gene Expression Tech. Co., Ltd. Double-stranded polyethylene glycol modified growth hormone, preparation method and application thereof
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JP5766118B2 (ja) * 2008-09-11 2015-08-19 ウェルズ ファーゴ バンク ナショナル アソシエイション ポリマー性アルファ−ヒドロキシアルデヒドおよびケトン反応剤ならびに抱合方法
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101104574B1 (ko) * 2008-05-14 2012-01-11 성균관대학교산학협력단 폴리에틸렌글리콜로 화학적으로 수식된 인간 성장 호르몬, 이의 제조방법 및 용도

Also Published As

Publication number Publication date
EA200400565A1 (ru) 2005-06-30
HRP20040448A2 (en) 2006-02-28
WO2003044056A2 (en) 2003-05-30
IS7268A (is) 2004-05-17
AU2002356990A1 (en) 2003-06-10
ECSP045114A (es) 2004-07-23
MXPA04004809A (es) 2004-08-11
NO20042182L (no) 2004-08-11
JP2006321808A (ja) 2006-11-30
BR0214451A (pt) 2006-05-30
CN1608079A (zh) 2005-04-20
AP2004003050A0 (en) 2004-06-30
EP1453859A2 (en) 2004-09-08
RS53104A (en) 2006-10-27
EA008505B1 (ru) 2007-06-29
EA200700431A1 (ru) 2008-02-28
ZA200403907B (en) 2007-12-27
WO2003044056A3 (en) 2003-08-21
TNSN04090A1 (fr) 2006-06-01
HUP0500997A2 (en) 2007-11-28
GEP20063860B (en) 2006-06-26
IL162031A0 (en) 2005-11-20
OA13063A (en) 2006-11-10
CO5580794A2 (es) 2005-11-30
CA2467731A1 (en) 2003-05-30
KR20050044858A (ko) 2005-05-13
PL374354A1 (en) 2005-10-17
JP2005525302A (ja) 2005-08-25
MA27544A1 (fr) 2005-10-03

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