KR20060123452A - 나프티리딘 유도체 및 무스카린 수용체의 조절자로서의이의 용도 - Google Patents
나프티리딘 유도체 및 무스카린 수용체의 조절자로서의이의 용도 Download PDFInfo
- Publication number
- KR20060123452A KR20060123452A KR1020067013734A KR20067013734A KR20060123452A KR 20060123452 A KR20060123452 A KR 20060123452A KR 1020067013734 A KR1020067013734 A KR 1020067013734A KR 20067013734 A KR20067013734 A KR 20067013734A KR 20060123452 A KR20060123452 A KR 20060123452A
- Authority
- KR
- South Korea
- Prior art keywords
- naphthyridin
- ylamine
- aliphatic
- ord
- phenyl
- Prior art date
Links
- 0 *c(cc1)ccc1-c1nc(ccnc2)c2c(C(O)=O)c1 Chemical compound *c(cc1)ccc1-c1nc(ccnc2)c2c(C(O)=O)c1 0.000 description 2
- BMHMKWXYXFBWMI-UHFFFAOYSA-N CC(c(cc1)cc2c1OCO2)=O Chemical compound CC(c(cc1)cc2c1OCO2)=O BMHMKWXYXFBWMI-UHFFFAOYSA-N 0.000 description 1
- NTPLXRHDUXRPNE-UHFFFAOYSA-N CC(c(cc1)ccc1OC)=O Chemical compound CC(c(cc1)ccc1OC)=O NTPLXRHDUXRPNE-UHFFFAOYSA-N 0.000 description 1
- MFUDNTSPFDDODU-UHFFFAOYSA-N CCOC(C(c1ccncc1NC(C(C)(C)C)=O)=O)=O Chemical compound CCOC(C(c1ccncc1NC(C(C)(C)C)=O)=O)=O MFUDNTSPFDDODU-UHFFFAOYSA-N 0.000 description 1
- MAYHAJDLOHTAAA-UHFFFAOYSA-N CCOC(C(c1cnccc1NC(C(C)(C)C)=O)=O)=O Chemical compound CCOC(C(c1cnccc1NC(C(C)(C)C)=O)=O)=O MAYHAJDLOHTAAA-UHFFFAOYSA-N 0.000 description 1
- OFXNVWAKKLTDMN-UHFFFAOYSA-N COc(cc1)ccc1-c1nc(ccnc2)c2c(C(O)=O)c1 Chemical compound COc(cc1)ccc1-c1nc(ccnc2)c2c(C(O)=O)c1 OFXNVWAKKLTDMN-UHFFFAOYSA-N 0.000 description 1
- JAFXDXBPJVPTHP-UHFFFAOYSA-N COc(cc1)ccc1-c1nc(ccnc2)c2c(N)c1 Chemical compound COc(cc1)ccc1-c1nc(ccnc2)c2c(N)c1 JAFXDXBPJVPTHP-UHFFFAOYSA-N 0.000 description 1
- JIVADFGWAPZEEM-UHFFFAOYSA-N Nc1cc(-c2cc(Cl)ccc2)nc2c1cccn2 Chemical compound Nc1cc(-c2cc(Cl)ccc2)nc2c1cccn2 JIVADFGWAPZEEM-UHFFFAOYSA-N 0.000 description 1
- NJJAPXFDSQOEDF-UHFFFAOYSA-N Nc1cc(-c2cccc(Cl)c2)nc2c1cncc2 Chemical compound Nc1cc(-c2cccc(Cl)c2)nc2c1cncc2 NJJAPXFDSQOEDF-UHFFFAOYSA-N 0.000 description 1
- NUZMTJRCTKAVME-UHFFFAOYSA-N Nc1cc(-c2ccccc2)nc2c1cccn2 Chemical compound Nc1cc(-c2ccccc2)nc2c1cccn2 NUZMTJRCTKAVME-UHFFFAOYSA-N 0.000 description 1
- QWGLTYHYDLCGKR-UHFFFAOYSA-N OC(c1cc(-c2ccc3OCOc3c2)nc2c1ccnc2)=O Chemical compound OC(c1cc(-c2ccc3OCOc3c2)nc2c1ccnc2)=O QWGLTYHYDLCGKR-UHFFFAOYSA-N 0.000 description 1
- JVPWODMAVYFOJB-UHFFFAOYSA-N OC(c1cc(-c2cccc(Cl)c2)nc2c1cccn2)=O Chemical compound OC(c1cc(-c2cccc(Cl)c2)nc2c1cccn2)=O JVPWODMAVYFOJB-UHFFFAOYSA-N 0.000 description 1
- KTDIDVQPCXJTIM-UHFFFAOYSA-N OC(c1cc(-c2ccccc2)nc2c1cccn2)=O Chemical compound OC(c1cc(-c2ccccc2)nc2c1cccn2)=O KTDIDVQPCXJTIM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52804903P | 2003-12-09 | 2003-12-09 | |
| US60/528,049 | 2003-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20060123452A true KR20060123452A (ko) | 2006-12-01 |
Family
ID=34676813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067013734A KR20060123452A (ko) | 2003-12-09 | 2004-12-07 | 나프티리딘 유도체 및 무스카린 수용체의 조절자로서의이의 용도 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7446112B2 (fr) |
| EP (1) | EP1709045A1 (fr) |
| JP (1) | JP2007513955A (fr) |
| KR (1) | KR20060123452A (fr) |
| CN (1) | CN1914204A (fr) |
| AU (1) | AU2004297241A1 (fr) |
| CA (1) | CA2548009A1 (fr) |
| IL (1) | IL176215A0 (fr) |
| MX (1) | MXPA06006532A (fr) |
| NO (1) | NO20063132L (fr) |
| RU (1) | RU2006124559A (fr) |
| WO (1) | WO2005056552A1 (fr) |
| ZA (1) | ZA200604721B (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011217561B2 (en) * | 2010-02-22 | 2016-04-21 | Merck Patent Gmbh | Hetarylaminonaphthyridines |
| US8507494B2 (en) | 2010-04-30 | 2013-08-13 | Merck Sharp & Dohme Corp. | Heterocyclic quinolizine derived M1 receptor positive allosteric modulators |
| US8815902B2 (en) | 2010-06-15 | 2014-08-26 | Merck Sharp & Dohme Corp. | Tetrahydroquinoline amide M1 receptor positive allosteric modulators |
| EP2582241B1 (fr) | 2010-06-15 | 2016-04-06 | Merck Sharp & Dohme Corp. | Compposés de phénanthrolinone fusionnés hétérocycliques utiles comme modulateurs allostériques positifs du récepteur m1 |
| WO2012003147A1 (fr) | 2010-07-01 | 2012-01-05 | Merck Sharp & Dohme Corp. | Modulateurs allostériques positifs du récepteur m1 de l'isoindolone |
| WO2012158473A1 (fr) | 2011-05-17 | 2012-11-22 | Merck Sharp & Dohme Corp. | Modulateurs allostériques positifs du récepteur m1 au n-méthyl tétrahydro-quinoline |
| US8940765B2 (en) | 2011-05-17 | 2015-01-27 | Merck Sharp & Dohme Corp. | N-linked quinolineamide M1 receptor positive allosteric modulators |
| EP2709451B1 (fr) | 2011-05-17 | 2015-12-30 | Merck Sharp & Dohme Corp. | Modulateurs allostériques positifs du récepteur m1 contenant des lactames liés à n |
| JP2016508487A (ja) * | 2013-01-28 | 2016-03-22 | ヴィアメット ファーマスーティカルズ，インコーポレイテッド | 金属酵素阻害剤化合物 |
| CN107427506A (zh) | 2014-10-14 | 2017-12-01 | 拉霍拉敏感及免疫学研究所 | 低分子量蛋白酪氨酸磷酸酶的抑制剂及其用途 |
| US10435403B2 (en) | 2015-06-09 | 2019-10-08 | Bayer Pharma Aktiengesellschaft | Positive allosteric modulators of muscarinic M2 receptor |
| CN105646462B (zh) * | 2016-01-19 | 2019-04-05 | 河南大学 | 芸香宁碱衍生物、其制备方法及应用 |
| WO2017160670A1 (fr) * | 2016-03-16 | 2017-09-21 | Merck Sharp & Dohme Corp. | Modulateurs allostériques positifs du récepteur m1 et procédés pour les utiliser |
| JP2019524722A (ja) | 2016-07-11 | 2019-09-05 | バイエル・ファルマ・アクティエンゲゼルシャフト | ７−置換１−ピリジル−ナフチリジン−３−カルボン酸アミドおよびその使用 |
| JOP20190045A1 (ar) * | 2016-09-14 | 2019-03-14 | Bayer Ag | مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها. |
| EP3296298A1 (fr) * | 2016-09-14 | 2018-03-21 | Bayer Pharma Aktiengesellschaft | 1-aryl-naphtyridin-3-ylcarboxamides substitués en position 7 et leur utilisation |
| EA038451B1 (ru) * | 2016-12-06 | 2021-08-30 | Байер Акциенгезельшафт | 7-замещенные 1-арил-нафтиридин-3-амиды карбоновых кислот и их применение |
| EP3619210A4 (fr) | 2017-05-01 | 2020-12-02 | Sanford Burnham Prebys Medical Discovery Institute | Inhibiteurs de la protéine tyrosine phosphatase de faible poids moléculaire (lmptp) et utilisations associées |
| US9855255B1 (en) | 2017-05-26 | 2018-01-02 | King Saud University | Substituted naphthyridinyl hydrazines as anti-liver cancer agents |
| IL301739A (en) | 2020-10-05 | 2023-05-01 | Enliven Therapeutics Inc | 5- and 6-Azaindole compounds for inhibition of BCR-ABL tyrosine kinases |
| IL302807A (en) | 2020-11-18 | 2023-07-01 | Deciphera Pharmaceuticals Llc | GCN2 and PERK kinase inhibitors and methods of using them |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6166203A (en) * | 1998-02-26 | 2000-12-26 | Neurogen Corporation | Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands |
| WO1999043681A1 (fr) * | 1998-02-26 | 1999-09-02 | Neurogen Corporation | Pyridines heteroaryle fondues substituees 4-(4-piperidylmethylamino); ligands du recepteur cerebral gaba |
| GB9822450D0 (en) * | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
| AU2910600A (en) * | 1999-02-12 | 2000-08-29 | Smithkline Beecham Plc | Phenyl urea and phenyl thiourea derivatives |
| US6613776B2 (en) * | 2000-09-15 | 2003-09-02 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| CA2422367C (fr) * | 2000-09-15 | 2010-05-18 | Vertex Pharmaceuticals Incorporated | Composes de pyrazole pouvant etre utilises comme inhibiteurs de la proteine kinase |
| US6660731B2 (en) * | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6610677B2 (en) * | 2000-09-15 | 2003-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| KR100947185B1 (ko) * | 2000-12-21 | 2010-03-15 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제 억제제로서 유용한 피라졸 화합물 및 이를 포함하는 조성물 |
| ITMI20012060A1 (it) * | 2001-10-05 | 2003-04-05 | Recordati Chem Pharm | Nuovi eterocilcli n-acilati |
| US7153889B2 (en) * | 2002-11-12 | 2006-12-26 | Abbott Laboratories | Bicyclic-substituted amines as histamine-3 receptor ligands |
-
2004
- 2004-12-07 EP EP04817977A patent/EP1709045A1/fr not_active Withdrawn
- 2004-12-07 WO PCT/US2004/040839 patent/WO2005056552A1/fr active Application Filing
- 2004-12-07 CN CNA2004800412909A patent/CN1914204A/zh active Pending
- 2004-12-07 KR KR1020067013734A patent/KR20060123452A/ko not_active Application Discontinuation
- 2004-12-07 AU AU2004297241A patent/AU2004297241A1/en not_active Abandoned
- 2004-12-07 MX MXPA06006532A patent/MXPA06006532A/es unknown
- 2004-12-07 JP JP2006543920A patent/JP2007513955A/ja not_active Withdrawn
- 2004-12-07 US US11/005,944 patent/US7446112B2/en not_active Expired - Fee Related
- 2004-12-07 RU RU2006124559/04A patent/RU2006124559A/ru not_active Application Discontinuation
- 2004-12-07 CA CA002548009A patent/CA2548009A1/fr not_active Abandoned
-
2006
- 2006-06-08 ZA ZA200604721A patent/ZA200604721B/xx unknown
- 2006-06-08 IL IL176215A patent/IL176215A0/en unknown
- 2006-07-05 NO NO20063132A patent/NO20063132L/no not_active Application Discontinuation
-
2008
- 2008-06-26 US US12/215,367 patent/US20090042928A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004297241A1 (en) | 2005-06-23 |
| US20050171141A1 (en) | 2005-08-04 |
| US7446112B2 (en) | 2008-11-04 |
| RU2006124559A (ru) | 2008-01-20 |
| MXPA06006532A (es) | 2006-08-23 |
| IL176215A0 (en) | 2006-10-05 |
| ZA200604721B (en) | 2008-03-26 |
| EP1709045A1 (fr) | 2006-10-11 |
| JP2007513955A (ja) | 2007-05-31 |
| CA2548009A1 (fr) | 2005-06-23 |
| CN1914204A (zh) | 2007-02-14 |
| US20090042928A1 (en) | 2009-02-12 |
| WO2005056552A1 (fr) | 2005-06-23 |
| NO20063132L (no) | 2006-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |