KR20060110305A - Ｅｇｆ 수용체에 대한 항체를 함유하는 약학적 제제 - Google Patents

Ｅｇｆ 수용체에 대한 항체를 함유하는 약학적 제제 Download PDF

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Publication number
KR20060110305A
KR20060110305A KR1020067010225A KR20067010225A KR20060110305A KR 20060110305 A KR20060110305 A KR 20060110305A KR 1020067010225 A KR1020067010225 A KR 1020067010225A KR 20067010225 A KR20067010225 A KR 20067010225A KR 20060110305 A KR20060110305 A KR 20060110305A
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KR
South Korea
Prior art keywords
formulation
salt
polyoxyethylene
mmol
solution
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KR1020067010225A
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English (en)
Korean (ko)
Inventor
한스-크리스티안 말러
로베르트 뮐러
Original Assignee
메르크 파텐트 게엠베하
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34609304&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20060110305(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 메르크 파텐트 게엠베하 filed Critical 메르크 파텐트 게엠베하
Publication of KR20060110305A publication Critical patent/KR20060110305A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
KR1020067010225A 2003-11-26 2004-10-26 Ｅｇｆ 수용체에 대한 항체를 함유하는 약학적 제제 KR20060110305A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10355251.0 2003-11-26
DE10355251A DE10355251A1 (de) 2003-11-26 2003-11-26 Pharmazeutische Zubereitung enthaltend einen Antikörper gegen den EGF-Rezeptor

Publications (1)

Publication Number Publication Date
KR20060110305A true KR20060110305A (ko) 2006-10-24

Family

ID=34609304

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020067010225A KR20060110305A (ko) 2003-11-26 2004-10-26 Ｅｇｆ 수용체에 대한 항체를 함유하는 약학적 제제

Country Status (31)

Country Link
US (2) US20050175611A1 (el)
EP (1) EP1687031B1 (el)
JP (1) JP2007512266A (el)
KR (1) KR20060110305A (el)
CN (1) CN1886158B (el)
AR (1) AR047949A1 (el)
AT (1) ATE457740T1 (el)
AU (1) AU2004298728B2 (el)
BR (1) BRPI0416986A (el)
CA (1) CA2547060A1 (el)
CO (1) CO5690620A2 (el)
CY (1) CY1110344T1 (el)
DE (2) DE10355251A1 (el)
DK (1) DK1687031T3 (el)
EC (1) ECSP066662A (el)
ES (1) ES2339671T3 (el)
HK (1) HK1095534A1 (el)
IL (1) IL175727A0 (el)
MX (1) MXPA06005901A (el)
MY (1) MY145214A (el)
NZ (1) NZ548129A (el)
PE (1) PE20050586A1 (el)
PL (1) PL1687031T3 (el)
PT (1) PT1687031E (el)
RU (1) RU2381036C2 (el)
SG (1) SG150550A1 (el)
SI (1) SI1687031T1 (el)
TW (1) TWI322693B (el)
UA (1) UA90460C2 (el)
WO (1) WO2005058365A1 (el)
ZA (1) ZA200605219B (el)

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US7879328B2 (en) * 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
JP5905184B2 (ja) * 2005-10-13 2016-04-20 ヒューマン ジノーム サイエンシーズ， インコーポレイテッドＨｕｍａｎ Ｇｅｎｏｍｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 自己抗体陽性疾患を有する患者の処置に使用するための方法および組成物
US9168286B2 (en) * 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
HUE034269T2 (en) 2005-12-29 2018-02-28 Janssen Biotech Inc Human anti-IL-23 antibodies, preparations, methods and applications
US8211649B2 (en) * 2006-03-31 2012-07-03 Human Genome Sciences, Inc. Methods of diagnosing and prognosing hodgkin's lymphoma
CN101426817B (zh) * 2006-04-21 2013-07-10 诺华有限公司 拮抗性抗-cd40抗体药物组合物
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WO2008079818A2 (en) * 2006-12-21 2008-07-03 Soluprin Pharmaceuticals, Inc. Intravenous administration of water soluble analgesic formulations
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KR20090056543A (ko) * 2007-11-30 2009-06-03 주식회사 녹십자 Ｂ형 간염 바이러스(ｈｂｖ) 중화 인간 항체를 포함하는약학적 제제
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CN101797383A (zh) * 2009-02-05 2010-08-11 哈药集团生物工程有限公司 一种单克隆抗体的水针制剂
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JP2014529330A (ja) * 2011-06-16 2014-11-06 ディーエスエム アイピー アセッツ ビー．ブイ． 単一ユニットクロマトグラフィー抗体精製
AR087305A1 (es) 2011-07-28 2014-03-12 Regeneron Pharma Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
TWI589299B (zh) 2011-10-11 2017-07-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法
CN107233569B (zh) 2011-10-25 2021-08-31 普罗西纳生物科学有限公司 抗体制剂和方法
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Also Published As

Publication number Publication date
PE20050586A1 (es) 2005-08-15
WO2005058365A1 (de) 2005-06-30
DE10355251A1 (de) 2005-06-23
IL175727A0 (en) 2006-09-05
PT1687031E (pt) 2010-05-21
EP1687031A1 (de) 2006-08-09
PL1687031T3 (pl) 2010-06-30
CA2547060A1 (en) 2005-06-30
DK1687031T3 (da) 2010-05-31
AU2004298728A1 (en) 2005-06-30
MXPA06005901A (es) 2006-06-27
TWI322693B (en) 2010-04-01
EP1687031B1 (de) 2010-02-17
ES2339671T3 (es) 2010-05-24
UA90460C2 (ru) 2010-05-11
DE502004010783D1 (de) 2010-04-01
CN1886158A (zh) 2006-12-27
RU2381036C2 (ru) 2010-02-10
TW200531702A (en) 2005-10-01
ZA200605219B (en) 2007-04-25
HK1095534A1 (en) 2007-05-11
CY1110344T1 (el) 2015-01-14
ATE457740T1 (de) 2010-03-15
NZ548129A (en) 2010-09-30
ECSP066662A (es) 2006-10-25
SG150550A1 (en) 2009-03-30
AU2004298728B2 (en) 2010-09-16
RU2006122638A (ru) 2008-01-10
US20110177068A1 (en) 2011-07-21
JP2007512266A (ja) 2007-05-17
MY145214A (en) 2012-01-13
AR047949A1 (es) 2006-03-15
CO5690620A2 (es) 2006-10-31
CN1886158B (zh) 2011-09-07
US20050175611A1 (en) 2005-08-11
SI1687031T1 (sl) 2010-04-30
BRPI0416986A (pt) 2007-02-06

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