KR20050013260A - 카스파제 억제제 및 이의 용도 - Google Patents
카스파제 억제제 및 이의 용도Info
- Publication number
- KR20050013260A KR20050013260A KR10-2004-7021300A KR20047021300A KR20050013260A KR 20050013260 A KR20050013260 A KR 20050013260A KR 20047021300 A KR20047021300 A KR 20047021300A KR 20050013260 A KR20050013260 A KR 20050013260A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- disease
- halo
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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| US8987306B2 (en) * | 2005-06-07 | 2015-03-24 | The Trustees Of The University Of Pennsylvania | Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold |
| KR20080038369A (ko) | 2005-07-28 | 2008-05-06 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 프로드럭 |
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| US20100092556A1 (en) * | 2006-12-11 | 2010-04-15 | Kristin Arnold | Alfuzosin formulations, methods of making, and methods of use |
| FR2923160B1 (fr) | 2007-11-02 | 2013-07-26 | Pasteur Institut | Composes destines a prevenir ou traiter une infection virale. |
| US9116157B2 (en) | 2010-11-05 | 2015-08-25 | Brandeis University | Ice-cleaved alpha-synuclein as a biomarker |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
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| ES2751652T3 (es) | 2014-05-12 | 2020-04-01 | Conatus Pharmaceuticals Inc | Tratamiento con inhibidor de caspasa emricasan de las complicaciones por las enfermedades hepáticas crónicas |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| JP2019500397A (ja) | 2015-12-31 | 2019-01-10 | クオナトウス ファーマシューティカルズ，インコーポレイテッド | カスパーゼ阻害剤を肝疾患の治療に使用する方法 |
| RU2019113150A (ru) | 2016-10-05 | 2020-11-06 | Новартис Аг | Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения |
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| US5756466A (en) | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5847135A (en) | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
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2003
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- 2003-06-27 BR BR0312232-8A patent/BR0312232A/pt not_active IP Right Cessation
- 2003-06-27 CN CNB038187930A patent/CN100503572C/zh not_active Expired - Fee Related
- 2003-06-27 EP EP03762231A patent/EP1539701A1/en not_active Withdrawn
- 2003-06-27 AR ARP030102352A patent/AR040350A1/es unknown
- 2003-06-27 KR KR10-2004-7021300A patent/KR20050013260A/ko not_active Ceased
- 2003-06-27 CA CA002493646A patent/CA2493646A1/en not_active Abandoned
- 2003-06-27 RU RU2005102094/04A patent/RU2005102094A/ru unknown
- 2003-06-27 US US10/609,147 patent/US7553852B2/en not_active Expired - Fee Related
- 2003-06-27 AU AU2003248758A patent/AU2003248758A1/en not_active Abandoned
- 2003-06-27 PL PL03374598A patent/PL374598A1/xx not_active Application Discontinuation
- 2003-06-27 JP JP2004518103A patent/JP4616643B2/ja not_active Expired - Fee Related
- 2003-06-27 NZ NZ537807A patent/NZ537807A/en unknown
- 2003-06-27 TW TW092117681A patent/TW200404783A/zh unknown
- 2003-06-27 WO PCT/US2003/020557 patent/WO2004002961A1/en not_active Ceased
- 2003-06-30 UY UY27872A patent/UY27872A1/es unknown
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2005
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2009
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2010
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Also Published As
| Publication number | Publication date |
|---|---|
| BR0312232A (pt) | 2005-05-10 |
| WO2004002961A1 (en) | 2004-01-08 |
| US20040072850A1 (en) | 2004-04-15 |
| EP1539701A1 (en) | 2005-06-15 |
| JP4616643B2 (ja) | 2011-01-19 |
| TW200404783A (en) | 2004-04-01 |
| US7553852B2 (en) | 2009-06-30 |
| RU2005102094A (ru) | 2006-02-27 |
| NZ537807A (en) | 2007-05-31 |
| UY27872A1 (es) | 2003-12-31 |
| JP2010143942A (ja) | 2010-07-01 |
| CN100503572C (zh) | 2009-06-24 |
| CA2493646A1 (en) | 2004-01-08 |
| PE20040728A1 (es) | 2004-10-23 |
| MXPA05000069A (es) | 2005-04-11 |
| US8129381B2 (en) | 2012-03-06 |
| CN1675184A (zh) | 2005-09-28 |
| AU2003248758A1 (en) | 2004-01-19 |
| US20090281128A1 (en) | 2009-11-12 |
| NO20050851L (no) | 2005-03-29 |
| AR040350A1 (es) | 2005-03-30 |
| JP2005533825A (ja) | 2005-11-10 |
| PL374598A1 (en) | 2005-10-31 |
| IL165986A0 (en) | 2006-01-15 |
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