JP2003516393A5 - - Google Patents

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Publication number
JP2003516393A5
JP2003516393A5 JP2001543517A JP2001543517A JP2003516393A5 JP 2003516393 A5 JP2003516393 A5 JP 2003516393A5 JP 2001543517 A JP2001543517 A JP 2001543517A JP 2001543517 A JP2001543517 A JP 2001543517A JP 2003516393 A5 JP2003516393 A5 JP 2003516393A5
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JP
Japan
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oxo
compound
acid
substituted
embedded image
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JP2001543517A
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English (en)
Japanese (ja)
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JP5021131B2 (ja
JP2003516393A (ja
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Priority claimed from PCT/US2000/033260 external-priority patent/WO2001042216A2/en
Publication of JP2003516393A publication Critical patent/JP2003516393A/ja
Publication of JP2003516393A5 publication Critical patent/JP2003516393A5/ja
Application granted granted Critical
Publication of JP5021131B2 publication Critical patent/JP5021131B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2001543517A 1999-12-08 2000-12-08 カスパーゼインヒビターおよびその使用 Expired - Fee Related JP5021131B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16981299P 1999-12-08 1999-12-08
US60/169,812 1999-12-08
PCT/US2000/033260 WO2001042216A2 (en) 1999-12-08 2000-12-08 Caspase inhibitors and uses thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2007315252A Division JP2008101019A (ja) 1999-12-08 2007-12-05 カスパーゼインヒビターおよびその使用
JP2011234386A Division JP2012021032A (ja) 1999-12-08 2011-10-25 カスパーゼインヒビターおよびその使用

Publications (3)

Publication Number Publication Date
JP2003516393A JP2003516393A (ja) 2003-05-13
JP2003516393A5 true JP2003516393A5 (https=) 2008-01-31
JP5021131B2 JP5021131B2 (ja) 2012-09-05

Family

ID=22617272

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2001543517A Expired - Fee Related JP5021131B2 (ja) 1999-12-08 2000-12-08 カスパーゼインヒビターおよびその使用
JP2007315252A Withdrawn JP2008101019A (ja) 1999-12-08 2007-12-05 カスパーゼインヒビターおよびその使用
JP2011234386A Withdrawn JP2012021032A (ja) 1999-12-08 2011-10-25 カスパーゼインヒビターおよびその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2007315252A Withdrawn JP2008101019A (ja) 1999-12-08 2007-12-05 カスパーゼインヒビターおよびその使用
JP2011234386A Withdrawn JP2012021032A (ja) 1999-12-08 2011-10-25 カスパーゼインヒビターおよびその使用

Country Status (24)

Country Link
US (4) US7517987B2 (https=)
EP (4) EP2308846A3 (https=)
JP (3) JP5021131B2 (https=)
KR (3) KR100904697B1 (https=)
CN (2) CN101348455A (https=)
AP (1) AP2002002535A0 (https=)
AR (1) AR026748A1 (https=)
AU (3) AU2428301A (https=)
BR (1) BR0016282A (https=)
CA (2) CA2393710C (https=)
CO (1) CO5261609A1 (https=)
CZ (1) CZ20021970A3 (https=)
EA (1) EA200200645A1 (https=)
HU (1) HUP0300782A3 (https=)
IL (1) IL150077A0 (https=)
IS (1) IS6411A (https=)
MX (1) MXPA02005779A (https=)
NO (2) NO324776B1 (https=)
NZ (2) NZ519424A (https=)
PL (1) PL356066A1 (https=)
SK (1) SK8072002A3 (https=)
TW (1) TWI275586B (https=)
WO (1) WO2001042216A2 (https=)
ZA (1) ZA200204390B (https=)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1176941C (zh) 1999-04-09 2004-11-24 西托维亚公司 Caspase抑制剂及其应用
US6723711B2 (en) 1999-05-07 2004-04-20 Texas Biotechnology Corporation Propanoic acid derivatives that inhibit the binding of integrins to their receptors
CN1235875C (zh) 1999-08-27 2006-01-11 西托维亚公司 取代的α-羟基酸天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
AR026748A1 (es) * 1999-12-08 2003-02-26 Vertex Pharma Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
JP4428926B2 (ja) * 2001-05-23 2010-03-10 バーテックス ファーマシューティカルズ インコーポレイテッド カスパーゼインヒビターおよびそれらの使用
WO2003070701A2 (en) 2002-02-15 2003-08-28 Cytokinetics, Inc. Syntheses of quinazolinones
US7960398B2 (en) 2002-04-19 2011-06-14 Vertex Pharmaceuticals Incorporated Regulation of TNF-alpha
US7214800B2 (en) 2002-05-09 2007-05-08 Cytokinetics, Inc. Compounds, compositions, and methods
CA2485148A1 (en) 2002-05-09 2003-11-20 Cytokinetics, Inc. Pyrimidinone compounds, compositions and methods
EP1513820A4 (en) 2002-05-23 2006-09-13 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
WO2003106426A1 (en) 2002-06-14 2003-12-24 Cytokinetics, Inc. Compounds, compositions, and methods
PE20040728A1 (es) 2002-06-28 2004-10-23 Vertex Pharma Inhibidores de caspasa
AU2003256805A1 (en) 2002-07-23 2004-02-09 Cytokinetics, Inc. Compounds compositions and methods
WO2004034972A2 (en) 2002-09-30 2004-04-29 Cytokinetics, Inc. Compounds, compositions, and methods
TW200500343A (en) * 2002-12-20 2005-01-01 Vertex Pharma Caspase inhibitors and uses thereof
PE20050159A1 (es) * 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
WO2004113305A2 (en) * 2003-06-16 2004-12-29 Vertex Pharmaceuticals Incorporated Diamino substituted quinazoline derivatives as promoters of smn2
EP1692112A4 (en) 2003-12-08 2008-09-24 Cytokinetics Inc COMPOUNDS, COMPOSITIONS, AND METHODS
SG150547A1 (en) 2004-03-12 2009-03-30 Vertex Pharma Processes and intermediates
MXPA06013256A (es) * 2004-05-15 2007-02-08 Vertex Pharma Tratamiento de crisis convulsivas utilizando inhibidores ice.
CA2567080A1 (en) 2004-05-27 2005-12-15 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
ATE543803T1 (de) 2004-11-24 2012-02-15 Vertex Pharma 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren
KR20080038369A (ko) 2005-07-28 2008-05-06 버텍스 파마슈티칼스 인코포레이티드 카스파제 억제제 프로드럭
US8034822B2 (en) * 2006-03-08 2011-10-11 Takeda San Diego, Inc. Glucokinase activators
AR063417A1 (es) * 2006-11-01 2009-01-28 Astrazeneca Ab Compuestos inhibidores del activador de plasminogeno tipo 1(pai-1)
US8163779B2 (en) * 2006-12-20 2012-04-24 Takeda San Diego, Inc. Glucokinase activators
US8173645B2 (en) 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
DK2288615T3 (en) 2008-05-21 2017-09-04 Genesis Tech Ltd SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF
WO2010017408A1 (en) * 2008-08-06 2010-02-11 The Buck Institute For Age Research Caspase inhibitors and uses thereof
WO2010039534A2 (en) 2008-09-23 2010-04-08 Georgetown University Viral and fungal inhibitors
WO2010039545A2 (en) * 2008-09-23 2010-04-08 Georgetown University 1,2-benzisothiazolinone and isoindolinone derivatives
US9045524B2 (en) 2009-05-21 2015-06-02 Novagenesis Foundation Selective caspase inhibitors and uses thereof
WO2010138585A1 (en) * 2009-05-29 2010-12-02 Merck Sharp & Dohme Corp. Pyrimidinones as pde10 inhibitors
EP2470336B1 (en) 2009-08-25 2013-08-14 Lasermax Roll Systems, Inc. System and method for inline cutting and stacking of sheets for formation of books
US8882099B2 (en) 2009-08-25 2014-11-11 Lasermax Roll Systems, Inc. System and method for inline cutting and stacking of sheets for formation of books
WO2011094426A1 (en) 2010-01-29 2011-08-04 The United State Of America, As Represented By The Secretary, Department Of Health & Human Services Caspase inhibitors
US9116157B2 (en) 2010-11-05 2015-08-25 Brandeis University Ice-cleaved alpha-synuclein as a biomarker
AU2012236655B2 (en) 2011-03-28 2016-09-22 Deuterx, Llc, 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds
EP2697246B1 (en) 2011-04-15 2018-03-07 Genesis Technologies Limited Selective cysteine protease inhibitors and uses thereof
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
US9428472B2 (en) 2011-08-16 2016-08-30 Georgetown University Methods of treating bacterial infections with 1,2-benzisothiazolinone and isoindolinone derivatives
CA2935495C (en) 2013-01-14 2021-04-20 Deuterx, Llc 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives
EP2968334A4 (en) * 2013-03-14 2016-08-03 Deuterx Llc 3- (SUBSTITIERTES-4-OXO-quinazolin-3 (4H) -yl) -3-deutero-PIPERIDINE-2,6-DIONE DERIVATIVES
WO2014160592A2 (en) * 2013-03-27 2014-10-02 Merck Sharp & Dohme Corp. FACTOR XIa INHIBITORS
US9809603B1 (en) 2015-08-18 2017-11-07 Deuterx, Llc Deuterium-enriched isoindolinonyl-piperidinonyl conjugates and oxoquinazolin-3(4H)-yl-piperidinonyl conjugates and methods of treating medical disorders using same
WO2018133870A1 (zh) 2017-01-23 2018-07-26 正大天晴药业集团股份有限公司 作为Caspase抑制剂的联环化合物
CN106749045B (zh) * 2017-03-03 2020-02-14 上海交通大学 一种d-氨基酸氧化酶抑制剂及其制法和应用
WO2019070906A1 (en) * 2017-10-04 2019-04-11 Wright Aaron T PROBE FOR SELECTIVELY CHARACTERIZING ENZYMES INVOLVED IN XENOBIOTIC METABOLISM AND METHOD FOR MANUFACTURING AND USING SAME
JP2023518027A (ja) * 2020-03-13 2023-04-27 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク Gpx4化合物及び組成物、並びにそれを使用する治療方法
JP7566405B2 (ja) * 2020-08-05 2024-10-15 エルジー・ケム・リミテッド 変形性関節症の緩和又は治療するためのカスパーゼ阻害剤の使用
KR102670554B1 (ko) * 2022-01-04 2024-05-30 주식회사 이노보테라퓨틱스 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물
KR20250128292A (ko) * 2022-09-26 2025-08-27 엣지와이즈 테라퓨틱스, 인크. 1,4-디하이드로퀴나졸리논 화합물 및 이의 용도
WO2024206345A1 (en) 2023-03-27 2024-10-03 Edgewise Therapeutics, Inc. Quinazoline dione compounds and uses thereof
CN121194963A (zh) 2023-03-27 2025-12-23 艾知怀斯治疗学公司 喹啉酮酰胺类化合物及其用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
FR2582514B1 (fr) 1985-05-30 1988-02-19 Rhone Poulenc Sante Medicaments a base d'amides, nouveaux amides et leur preparation
EP0627926B1 (en) 1992-02-21 1998-08-05 Merck & Co., Inc. (a New Jersey corp.) PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME
US5714484A (en) * 1993-12-08 1998-02-03 Prototek, Inc. α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5847135A (en) 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
GB2292149A (en) 1994-08-09 1996-02-14 Ferring Res Ltd Peptide inhibitors of pro-interleukin-1beta converting enzyme
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
JPH11505532A (ja) * 1995-05-10 1999-05-21 カイロサイエンス・リミテッド 金属プロテアーゼとtnfの放出を抑制するペプチド化合物およびその治療的使用
US6252076B1 (en) * 1996-05-04 2001-06-26 Yuhan Corporation Process for preparation of pyrimidine derivatives
US6063794A (en) * 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
WO1998016502A1 (en) * 1996-10-11 1998-04-23 Warner-Lambert Company ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
NZ334906A (en) * 1996-10-11 2000-09-29 Basf Ag A sulphonamido pentanoic acid derivative useful as an interleukin-1-beta converting enzyme inhibitor
WO1998018781A2 (en) * 1996-10-28 1998-05-07 Versicor, Inc. Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents
US6972296B2 (en) 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
DK1176956T3 (da) 1999-05-07 2008-05-26 Encysive Pharmaceuticals Inc Carboxylsyrederivater, som inhiberer bindingen af integriner til deres receptorer
BR0010349B1 (pt) * 1999-05-07 2011-10-04 derivados de ácido propanóico que inibem a ligação de integrinas aos seus receptores.
AR026748A1 (es) * 1999-12-08 2003-02-26 Vertex Pharma Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis
US7410956B2 (en) * 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
US7960398B2 (en) * 2002-04-19 2011-06-14 Vertex Pharmaceuticals Incorporated Regulation of TNF-alpha

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