KR100904697B1 - 카스파제 저해제 및 그 용도 - Google Patents
카스파제 저해제 및 그 용도Info
- Publication number
- KR100904697B1 KR100904697B1 KR1020027007337A KR20027007337A KR100904697B1 KR 100904697 B1 KR100904697 B1 KR 100904697B1 KR 1020027007337 A KR1020027007337 A KR 1020027007337A KR 20027007337 A KR20027007337 A KR 20027007337A KR 100904697 B1 KR100904697 B1 KR 100904697B1
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- KR
- South Korea
- Prior art keywords
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- compound
- hydrogen
- oxo
- acid
- Prior art date
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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| JP4428926B2 (ja) * | 2001-05-23 | 2010-03-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼインヒビターおよびそれらの使用 |
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| WO2010039534A2 (en) | 2008-09-23 | 2010-04-08 | Georgetown University | Viral and fungal inhibitors |
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| US9045524B2 (en) | 2009-05-21 | 2015-06-02 | Novagenesis Foundation | Selective caspase inhibitors and uses thereof |
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| WO2011094426A1 (en) | 2010-01-29 | 2011-08-04 | The United State Of America, As Represented By The Secretary, Department Of Health & Human Services | Caspase inhibitors |
| US9116157B2 (en) | 2010-11-05 | 2015-08-25 | Brandeis University | Ice-cleaved alpha-synuclein as a biomarker |
| AU2012236655B2 (en) | 2011-03-28 | 2016-09-22 | Deuterx, Llc, | 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds |
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| CN106749045B (zh) * | 2017-03-03 | 2020-02-14 | 上海交通大学 | 一种d-氨基酸氧化酶抑制剂及其制法和应用 |
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| JP2023518027A (ja) * | 2020-03-13 | 2023-04-27 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | Gpx4化合物及び組成物、並びにそれを使用する治療方法 |
| JP7566405B2 (ja) * | 2020-08-05 | 2024-10-15 | エルジー・ケム・リミテッド | 変形性関節症の緩和又は治療するためのカスパーゼ阻害剤の使用 |
| KR102670554B1 (ko) * | 2022-01-04 | 2024-05-30 | 주식회사 이노보테라퓨틱스 | 캐스파제 저해제로서의 신규한 이소인돌리논 유도체 화합물 |
| KR20250128292A (ko) * | 2022-09-26 | 2025-08-27 | 엣지와이즈 테라퓨틱스, 인크. | 1,4-디하이드로퀴나졸리논 화합물 및 이의 용도 |
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| CN121194963A (zh) | 2023-03-27 | 2025-12-23 | 艾知怀斯治疗学公司 | 喹啉酮酰胺类化合物及其用途 |
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2000
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- 2000-12-07 CO CO00093694A patent/CO5261609A1/es not_active Application Discontinuation
- 2000-12-08 AU AU24283/01A patent/AU2428301A/en not_active Abandoned
- 2000-12-08 CN CNA2008101443995A patent/CN101348455A/zh active Pending
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- 2000-12-08 WO PCT/US2000/033260 patent/WO2001042216A2/en not_active Ceased
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- 2000-12-08 CZ CZ20021970A patent/CZ20021970A3/cs unknown
- 2000-12-08 EP EP00988026A patent/EP1244626A2/en not_active Withdrawn
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2002
- 2002-05-31 ZA ZA200204390A patent/ZA200204390B/xx unknown
- 2002-06-05 NO NO20022656A patent/NO324776B1/no not_active IP Right Cessation
- 2002-06-06 IS IS6411A patent/IS6411A/is unknown
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2006
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2008
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2009
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2010
- 2010-05-21 AU AU2010202075A patent/AU2010202075B2/en not_active Ceased
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2011
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