KR20040072635A - 각막 상피형 시트, 및 그의 제조 방법 - Google Patents
각막 상피형 시트, 및 그의 제조 방법 Download PDFInfo
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- KR20040072635A KR20040072635A KR10-2004-7007655A KR20047007655A KR20040072635A KR 20040072635 A KR20040072635 A KR 20040072635A KR 20047007655 A KR20047007655 A KR 20047007655A KR 20040072635 A KR20040072635 A KR 20040072635A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3666—Epithelial tissues other than skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Oral & Maxillofacial Surgery (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
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- Dermatology (AREA)
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- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Tents Or Canopies (AREA)
- External Artificial Organs (AREA)
- Adornments (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (18)
- 구강 점막 상피 세포 유래의 세포가 중층화한 세포층으로 이루어지는 각막 상피형 시트.
- 제1항에 있어서,최표층(最表層)의 세포가 각화되어 있지 않은 것을 특징으로 하는 각막 상피형 시트.
- 제1항 또는 제2항에 있어서,최표층의 세포가 편평 형상인 것을 특징으로 하는 각막 상피형 시트.
- 제1항 내지 제3항 중 어느 한 항에 있어서,배리어 기능을 구비하는 것을 특징으로 하는 각막 상피형 시트.
- 콜라겐층 상에, 구강 점막 상피 세포 유래의 세포가 중층화한 세포층이 형성된 것을 특징으로 하는 각막 상피 이식용 시트.
- 제5항에 있어서,상기 세포층의 최표층의 세포가 각화되어 있지 않은 것을 특징으로 하는 각막 상피 이식용 시트.
- 제5항 또는 제6항에 있어서,상기 세포층의 최표층의 세포가 편평 형상인 것을 특징으로 하는 각막 상피 이식용 시트.
- 제5항 내지 제7항 중 어느 한 항에 있어서,상기 콜라겐층이 양막(羊膜) 유래인 것을 특징으로 하는 각막 상피 이식용 시트.
- 제5항 내지 제7항 중 어느 한 항에 있어서,상기 콜라겐층이 상피를 제거한 양막으로 이루어지는 것을 특징으로 하는 각막 상피 이식용 시트.
- 제5항 내지 제9항 중 어느 한 항에 있어서,배리어 기능을 가지는 것을 특징으로 하는 각막 상피 이식용 시트.
- a) 콜라겐층 상에서 구강 점막 상피 세포를 배양하는 단계; 및b) 구강 점막 상피 세포를 증식시켜 중층화한 후, 최표층을 공기에 접촉시키는 단계를 포함하는 각막 상피형 시트의 제조 방법.
- 제11항에 있어서,상기 단계 a)가 지지 세포의 공존 하에 실시되는 것을 특징으로 하는 각막 상피형 시트의 제조 방법.
- 제11항에 있어서,상기 단계 a)가 지지 세포의 공존 하에, 상기 지지 세포와 상기 콜라겐층 사이에, 지지 세포가 통과할 수 없는 세공 크기(pore size)의 격리막이 존재하는 상태에서 실시되는 것을 특징으로 하는 각막 상피형 시트의 제조 방법.
- 제11항 내지 제13항 중 어느 한 항에 있어서,상기 콜라겐층이 양막 유래인 것을 특징으로 하는 각막 상피형 시트의 제조 방법.
- 제11항 내지 제13항 중 어느 한 항에 있어서,상기 콜라겐층이 상피를 제거한 양막으로 이루어지는 것을 특징으로 하는 각막 상피형 시트의 제조 방법.
- 제1 용기 내에 지지 세포를 접종하여, 지지 세포의 층을 형성시키는 단계;상기 지지 세포가 통과할 수 없는 세공 크기(pore size)의 격리막으로 이루어지는 바닥면을 가지는 제2 용기를, 상기 바닥면이 배양액 중에 잠기도록 상기 제1 용기 내에 배치하는 단계;상기 제2 용기의 바닥면 상에 콜라겐층을 형성시키는 단계;상기 콜라겐층 상에 구강 점막 상피 세포를 접종하는 단계;상기 구강 점막 상피 세포를 배양하여 중층화시키는 단계; 및중층화한 구강 점막 상피 세포의 최표층을 공기에 접촉시키는 단계를 포함하는 각막 상피형 시트의 제조 방법.
- 제16항에 있어서,상기 콜라겐층이 양막 유래인 것을 특징으로 하는 각막 상피형 시트의 제조 방법.
- 제16항에 있어서,상기 콜라겐층이 상피를 제거한 양막으로 이루어지는 것을 특징으로 하는 각막 상피형 시트의 제조 방법.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JPJP-P-2001-00352675 | 2001-11-19 | ||
JP2001352675 | 2001-11-19 | ||
PCT/JP2002/011857 WO2003043542A1 (en) | 2001-11-19 | 2002-11-13 | Ectocornea-like sheet and method of constructing the same |
Publications (2)
Publication Number | Publication Date |
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KR20040072635A true KR20040072635A (ko) | 2004-08-18 |
KR100940765B1 KR100940765B1 (ko) | 2010-02-10 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020047007655A KR100940765B1 (ko) | 2001-11-19 | 2002-11-13 | 각막 상피형 시트, 및 그의 제조 방법 |
Country Status (11)
Country | Link |
---|---|
US (3) | US20050003532A1 (ko) |
EP (1) | EP1454600B1 (ko) |
JP (1) | JP4392855B2 (ko) |
KR (1) | KR100940765B1 (ko) |
CN (1) | CN100360095C (ko) |
AT (1) | ATE522185T1 (ko) |
AU (1) | AU2002343774A1 (ko) |
CA (1) | CA2466903A1 (ko) |
DE (1) | DE2780078T9 (ko) |
ES (1) | ES2372814T3 (ko) |
WO (1) | WO2003043542A1 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20170002194U (ko) | 2016-03-29 | 2017-06-21 | 다나제약 주식회사 | 분할형 의료 패치 |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4576545B2 (ja) * | 2004-05-27 | 2010-11-10 | 独立行政法人理化学研究所 | 羊膜由来因子による胚性幹細胞の培養方法 |
CN101014375A (zh) * | 2004-06-30 | 2007-08-08 | 阿如布勒斯特有限公司 | 角膜上皮片及其制作方法 |
WO2006129673A1 (ja) * | 2005-05-30 | 2006-12-07 | Arblast Co., Ltd. | 組織再建用材料及びその使用 |
ES2437865T3 (es) | 2005-07-25 | 2014-01-14 | Foundation For Biomedical Research And Innovation | Composición en forma de lámina |
WO2007023750A1 (ja) | 2005-08-26 | 2007-03-01 | National University Corporation University Of Toyama | 乾燥羊膜及び羊膜の乾燥処理方法 |
WO2007029676A1 (ja) * | 2005-09-07 | 2007-03-15 | Arblast Co., Ltd. | 生体組織シート及びその作製方法 |
CN1916166B (zh) * | 2006-09-08 | 2010-08-11 | 北京赛尔泰和生物医药科技有限公司 | 自体角膜上皮的制备方法 |
JP5181172B2 (ja) * | 2007-02-21 | 2013-04-10 | 国立大学法人富山大学 | 培養重層上皮シートの作製方法 |
WO2009110647A1 (en) * | 2008-03-03 | 2009-09-11 | Modern Cell & Tissue Technologies Inc. | Tissue sheet of cornea or conjunctiva using nasal mucosa epithelium |
KR100996846B1 (ko) | 2008-03-03 | 2010-11-26 | 주식회사 엠씨티티 | 비점막 상피세포를 이용한 각막 또는 결막 조직 시트 |
MX2010010213A (es) | 2008-03-19 | 2010-10-05 | Senju Pharma Co | Peptido parcial de lacritina. |
CN102725399B (zh) * | 2009-12-18 | 2015-03-11 | 上海赛傲生物技术有限公司 | 制备多能干细胞的材料和方法 |
DE102010001271B8 (de) * | 2010-01-27 | 2012-12-06 | Urotiss Gmbh | Vernähbares Gewebetransplantatkonstrukt zur Rekonstruktion eines menschlichen oder tierischen Organs |
CN101757690B (zh) * | 2010-02-05 | 2013-04-24 | 陕西瑞盛生物科技有限公司 | 一种制备组织工程角膜的方法 |
US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
WO2016114242A1 (ja) | 2015-01-13 | 2016-07-21 | 国立大学法人大阪大学 | 表面外胚葉系細胞から誘導された角膜上皮様細胞 |
US10531957B2 (en) | 2015-05-21 | 2020-01-14 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
CN105238691A (zh) * | 2015-11-13 | 2016-01-13 | 张志华 | 一种用于人工角膜重建的细胞种植模型 |
WO2017183655A1 (ja) * | 2016-04-20 | 2017-10-26 | 京都府公立大学法人 | 培養上皮シートの製造方法 |
CN108567995A (zh) * | 2017-03-10 | 2018-09-25 | 上海睿泰生物科技股份有限公司 | 一种用于角膜疾病治疗的上皮细胞片的制备方法及其应用 |
CN107335096A (zh) * | 2017-07-11 | 2017-11-10 | 上海白衣缘生物工程有限公司 | 一种复合口腔粘膜上皮细胞的口腔补片制备方法 |
CN113143584B (zh) * | 2021-03-09 | 2023-07-28 | 河南省立眼科医院 | 动物角膜上皮细胞收集及低温保存手持设备、收集方法 |
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US5032508A (en) | 1988-09-08 | 1991-07-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
US4888291A (en) * | 1987-06-19 | 1989-12-19 | President And Fellows Of Harvard College | Human epithelium originating from cell cultures |
US5015584A (en) * | 1987-10-14 | 1991-05-14 | Board Of Regents, The University Of Texas System | Epidermal graft system |
US5827641A (en) * | 1992-11-13 | 1998-10-27 | Parenteau; Nancy L. | In vitro cornea equivalent model |
WO1997045533A1 (en) * | 1996-05-28 | 1997-12-04 | The Regents Of The University Of Michigan | Engineering oral tissues |
US6143315A (en) * | 1997-07-24 | 2000-11-07 | Wang; Ming X. | Biochemical contact lens for treating injured corneal tissue |
CN1296102C (zh) * | 2000-04-27 | 2007-01-24 | 雷·瑞芳·蔡 | 上皮干细胞的扩展方法 |
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2002
- 2002-11-13 CA CA002466903A patent/CA2466903A1/en not_active Abandoned
- 2002-11-13 CN CNB028230116A patent/CN100360095C/zh not_active Expired - Lifetime
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- 2002-11-13 AU AU2002343774A patent/AU2002343774A1/en not_active Abandoned
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- 2002-11-13 KR KR1020047007655A patent/KR100940765B1/ko active IP Right Grant
- 2002-11-13 DE DE02780078T patent/DE2780078T9/de active Active
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2004
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2005
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20170002194U (ko) | 2016-03-29 | 2017-06-21 | 다나제약 주식회사 | 분할형 의료 패치 |
Also Published As
Publication number | Publication date |
---|---|
CN1589126A (zh) | 2005-03-02 |
WO2003043542A1 (en) | 2003-05-30 |
CN100360095C (zh) | 2008-01-09 |
ES2372814T3 (es) | 2012-01-26 |
ATE522185T1 (de) | 2011-09-15 |
US20050287126A1 (en) | 2005-12-29 |
CA2466903A1 (en) | 2003-05-30 |
KR100940765B1 (ko) | 2010-02-10 |
DE02780078T1 (de) | 2005-01-13 |
EP1454600A1 (en) | 2004-09-08 |
AU2002343774A1 (en) | 2003-06-10 |
US20140220102A1 (en) | 2014-08-07 |
EP1454600B1 (en) | 2011-08-31 |
DE2780078T9 (de) | 2005-05-19 |
JP4392855B2 (ja) | 2010-01-06 |
EP1454600A4 (en) | 2010-04-07 |
US20050003532A1 (en) | 2005-01-06 |
JPWO2003043542A1 (ja) | 2005-03-10 |
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