KR20040031772A - 은행의 잎 및 약제학적 분말로부터 테르펜트리락톤(징코라이드, 빌로바라이드)을 분리하는 방법 - Google Patents

은행의 잎 및 약제학적 분말로부터 테르펜트리락톤(징코라이드, 빌로바라이드)을 분리하는 방법 Download PDF

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Publication number
KR20040031772A
KR20040031772A KR10-2004-7000510A KR20047000510A KR20040031772A KR 20040031772 A KR20040031772 A KR 20040031772A KR 20047000510 A KR20047000510 A KR 20047000510A KR 20040031772 A KR20040031772 A KR 20040031772A
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KR
South Korea
Prior art keywords
extract
plant material
terpene trilactone
solution
separating
Prior art date
Application number
KR10-2004-7000510A
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English (en)
Korean (ko)
Inventor
딕 앤드리스 리츠블라우
존 베르게르
니나 베로바
코지 나카니시
Original Assignee
더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 filed Critical 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕
Publication of KR20040031772A publication Critical patent/KR20040031772A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR10-2004-7000510A 2001-07-11 2002-07-11 은행의 잎 및 약제학적 분말로부터 테르펜트리락톤(징코라이드, 빌로바라이드)을 분리하는 방법 KR20040031772A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90304901A 2001-07-11 2001-07-11
US09/903,049 2001-07-11
PCT/US2002/022101 WO2003006040A1 (fr) 2001-07-11 2002-07-11 Procede d'isolation de trilactones terpenes (ginkgolides, bilobalide) a partir de feuilles et de poudres pharmaceutiques de ginkgo biloba

Publications (1)

Publication Number Publication Date
KR20040031772A true KR20040031772A (ko) 2004-04-13

Family

ID=25416854

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2004-7000510A KR20040031772A (ko) 2001-07-11 2002-07-11 은행의 잎 및 약제학적 분말로부터 테르펜트리락톤(징코라이드, 빌로바라이드)을 분리하는 방법

Country Status (8)

Country Link
US (3) US6590109B2 (fr)
EP (1) EP1416949B1 (fr)
KR (1) KR20040031772A (fr)
AT (1) ATE343393T1 (fr)
CA (1) CA2453467A1 (fr)
DE (1) DE60215671T2 (fr)
HK (1) HK1065939A1 (fr)
WO (1) WO2003006040A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823116B1 (fr) * 2001-04-10 2004-11-19 Sod Conseils Rech Applic Procede de preparation d'une extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs
US6590109B2 (en) * 2001-07-11 2003-07-08 The Trustees Of Columbia University In The City Of New York Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba
AU2003243158A1 (en) 2002-03-29 2003-10-13 The Trustees Of Columbia University In The City Of New York Analogs of terpene trilactones from ginkgo biloba and related compounds and uses thereof
ITMI20031390A1 (it) * 2003-07-08 2005-01-09 Turispharma S R L Metodo di estrazione di strutture molecolari attive da resine naturali e/o da oli essenziali.
WO2005021496A2 (fr) * 2003-08-27 2005-03-10 The Trustees Of Columbia University In The City Of New York Synthese de derives de ginkgolide c
KR100579710B1 (ko) * 2003-09-16 2006-05-15 학교법인조선대학교 은행잎에서 분리한 비듬치료 및 탈모방지용 샴푸 조성물
WO2005046829A2 (fr) 2003-11-12 2005-05-26 The Trustees Of Columbia University In The City Of New York Séparation des gingolides d'avec le g.biloba
WO2005092324A1 (fr) * 2004-03-19 2005-10-06 The Trustees Of Columbia University In The City Of New York Composes, compositions et extraits de ginkgolides et utilisations
KR100623164B1 (ko) * 2004-07-22 2006-09-19 재단법인서울대학교산학협력재단 뇌신경 보호효과를 갖는 신규한 은행잎 엑스를 정제하는방법 및 이를 함유하는 조성물
US20080306145A1 (en) * 2004-11-23 2008-12-11 The Trustees Of Columbia University In The City Of New York Preparation Of Ginkgolide And F-Seco-Ginkgolide Lactols
WO2007002410A2 (fr) * 2005-06-22 2007-01-04 The Trustees Of Columbia University In The City Of New York Trilactones terpeniques d'extrait de ginkgo biloba a noyau modifie et evaluation biologique desdites trilactones
CN100462006C (zh) * 2006-02-21 2009-02-18 复旦大学 银杏酸在制备杀灭钉螺、防止血吸虫病的生物农药中的用途
CN102199159B (zh) * 2011-03-21 2013-07-03 贵州大学 从银杏根皮中分离、纯化银杏内酯c的方法
JP5461614B2 (ja) 2011-05-31 2014-04-02 株式会社Ｔｂｍ 無機物質粉末高配合薄膜シートの製造方法
CN103396421B (zh) * 2013-08-21 2016-03-30 上海信谊百路达药业有限公司 一种银杏内酯c的分离纯化方法
CN103524526B (zh) * 2013-10-15 2016-05-25 上海信谊百路达药业有限公司 一种白果内酯的分离纯化方法
CN104034826B (zh) * 2014-07-08 2015-12-02 上海信谊百路达药业有限公司 一种银杏叶提取物中萜类内酯的检测方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117429C3 (de) * 1971-04-08 1982-04-01 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Verfahren zur Herstellung eines Injektions- bzw. Infusionspräparates mit einem Gehalt an einem Wirkstoffgemisch aus den Blättern von Ginkgo biloba
FR2627387B1 (fr) 1988-02-24 1992-06-05 Fabre Sa Pierre Procede d'obtention d'un extrait de feuilles de ginkgo biloba
DE3940094A1 (de) * 1989-12-04 1991-06-06 Montana Ltd Wirkstoffkonzentrate und neue wirkstoff-kombinationen aus blaettern von ginkgo biloba, ein verfahren zu ihrer herstellung und die wirkstoff-konzentrate bzw. die wirkstoff-kombinationen enthaltenden arzneimittel
DE3940091A1 (de) 1989-12-04 1991-06-06 Schwabe Willmar Gmbh & Co Extrakt aus blaettern von ginkgo biloba, verfahren zu seiner herstellung und den extrakt enthaltende arzneimittel
DE4030758A1 (de) 1990-09-28 1992-04-02 Schwabe Willmar Gmbh & Co Extrakt aus blaettern von ginkgo biloba, insbesondere zur intravenoesen injektion oder infusion, verfahren zu seiner herstellung und den extrakt enthaltende ampullenpraeparate
KR930002507A (ko) * 1991-07-18 1993-02-23 김영중 식물세포 배양법에 의한 징콜라이드류의 제조방법
US6274621B1 (en) * 1995-11-09 2001-08-14 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Ginkgolides for inhibition of membrane expression of benzodiazepine receptors
US6221356B1 (en) 1996-12-13 2001-04-24 Viva America Marketing, Inc. Method of preparation of biologically active Ginkgo biloba product
FR2763592B1 (fr) 1997-05-20 1999-07-16 Sod Conseils Rech Applic Nouveaux derives glycosyles des ginkgolides, leur application en tant que medicaments et compositions pharmaceutiques les contenant
EP1033994A4 (fr) * 1997-11-25 2002-04-03 Pharmanex Inc Methodes de preparation de bioginko
DE19756848C2 (de) * 1997-12-19 2003-01-16 Schwabe Willmar Gmbh & Co Extrakte aus Blättern von Ginkgo biloba mit vermindertem Gehalt an 4'-O-Methylpyridoxin und Biflavonen
US6030621A (en) * 1998-03-19 2000-02-29 De Long; Xie Ginkgo biloba composition, method to prepare the same and uses thereof
US6117431A (en) 1999-12-03 2000-09-12 Pharmline Inc. Method for obtaining an extract from ginkgo biloba leaves
FR2823116B1 (fr) 2001-04-10 2004-11-19 Sod Conseils Rech Applic Procede de preparation d'une extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs
US6590109B2 (en) 2001-07-11 2003-07-08 The Trustees Of Columbia University In The City Of New York Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba
US6693091B2 (en) * 2002-03-29 2004-02-17 The Trustees Of Columbia University In The City Of New York Analogs of terpene trilactones from Ginkgo biloba for bioorganic and imaging studies

Also Published As

Publication number Publication date
US20030031736A1 (en) 2003-02-13
US20050136136A1 (en) 2005-06-23
EP1416949A4 (fr) 2005-11-16
CA2453467A1 (fr) 2003-01-23
ATE343393T1 (de) 2006-11-15
DE60215671T2 (de) 2007-09-06
US20040077883A1 (en) 2004-04-22
EP1416949B1 (fr) 2006-10-25
EP1416949A1 (fr) 2004-05-12
HK1065939A1 (en) 2005-03-11
US6844451B2 (en) 2005-01-18
WO2003006040A1 (fr) 2003-01-23
US6590109B2 (en) 2003-07-08
DE60215671D1 (de) 2006-12-07

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