DE60215671D1 - Verfahren zur isolierung von terpentrilactonen (ginkgoliden, bilobaliden) aus blättern und pharmazeutische pulver aus ginkgo biloba - Google Patents
Verfahren zur isolierung von terpentrilactonen (ginkgoliden, bilobaliden) aus blättern und pharmazeutische pulver aus ginkgo bilobaInfo
- Publication number
- DE60215671D1 DE60215671D1 DE60215671T DE60215671T DE60215671D1 DE 60215671 D1 DE60215671 D1 DE 60215671D1 DE 60215671 T DE60215671 T DE 60215671T DE 60215671 T DE60215671 T DE 60215671T DE 60215671 D1 DE60215671 D1 DE 60215671D1
- Authority
- DE
- Germany
- Prior art keywords
- acceptable
- organic layer
- terpene trilactones
- ginkgo biloba
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 244000194101 Ginkgo biloba Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- MOLPUWBMSBJXER-YDGSQGCISA-N Bilobalide Natural products O([C@H]1OC2=O)C(=O)[C@H](O)[C@@]11[C@@](C(C)(C)C)(O)C[C@H]3[C@@]21CC(=O)O3 MOLPUWBMSBJXER-YDGSQGCISA-N 0.000 title 1
- 235000008100 Ginkgo biloba Nutrition 0.000 title 1
- 229930184727 ginkgolide Natural products 0.000 title 1
- 238000009413 insulation Methods 0.000 title 1
- 239000000843 powder Substances 0.000 title 1
- 239000000284 extract Substances 0.000 abstract 4
- 150000003505 terpenes Chemical class 0.000 abstract 4
- 235000007586 terpenes Nutrition 0.000 abstract 4
- 239000012044 organic layer Substances 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000012670 alkaline solution Substances 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 239000010410 layer Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000011877 solvent mixture Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US903049 | 1997-07-30 | ||
| US90304901A | 2001-07-11 | 2001-07-11 | |
| PCT/US2002/022101 WO2003006040A1 (en) | 2001-07-11 | 2002-07-11 | Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60215671D1 true DE60215671D1 (de) | 2006-12-07 |
| DE60215671T2 DE60215671T2 (de) | 2007-09-06 |
Family
ID=25416854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60215671T Expired - Lifetime DE60215671T2 (de) | 2001-07-11 | 2002-07-11 | Verfahren zur isolierung von terpentrilactonen (ginkgoliden, bilobaliden) aus blättern und pharmazeutische pulver aus ginkgo biloba |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6590109B2 (de) |
| EP (1) | EP1416949B1 (de) |
| KR (1) | KR20040031772A (de) |
| AT (1) | ATE343393T1 (de) |
| CA (1) | CA2453467A1 (de) |
| DE (1) | DE60215671T2 (de) |
| HK (1) | HK1065939A1 (de) |
| WO (1) | WO2003006040A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2823116B1 (fr) * | 2001-04-10 | 2004-11-19 | Sod Conseils Rech Applic | Procede de preparation d'une extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs |
| US6590109B2 (en) * | 2001-07-11 | 2003-07-08 | The Trustees Of Columbia University In The City Of New York | Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba |
| AU2003243158A1 (en) | 2002-03-29 | 2003-10-13 | The Trustees Of Columbia University In The City Of New York | Analogs of terpene trilactones from ginkgo biloba and related compounds and uses thereof |
| ITMI20031390A1 (it) * | 2003-07-08 | 2005-01-09 | Turispharma S R L | Metodo di estrazione di strutture molecolari attive da resine naturali e/o da oli essenziali. |
| WO2005021496A2 (en) * | 2003-08-27 | 2005-03-10 | The Trustees Of Columbia University In The City Of New York | Synthesis of derivatives of ginkgolide c |
| KR100579710B1 (ko) * | 2003-09-16 | 2006-05-15 | 학교법인조선대학교 | 은행잎에서 분리한 비듬치료 및 탈모방지용 샴푸 조성물 |
| WO2005046829A2 (en) | 2003-11-12 | 2005-05-26 | The Trustees Of Columbia University In The City Of New York | Separation of ginkgolides and bilobalide from g. biloba |
| WO2005092324A1 (en) * | 2004-03-19 | 2005-10-06 | The Trustees Of Columbia University In The City Of New York | Ginkgolide compounds, compositions, extracts, and uses thereof |
| KR100623164B1 (ko) * | 2004-07-22 | 2006-09-19 | 재단법인서울대학교산학협력재단 | 뇌신경 보호효과를 갖는 신규한 은행잎 엑스를 정제하는방법 및 이를 함유하는 조성물 |
| US20080306145A1 (en) * | 2004-11-23 | 2008-12-11 | The Trustees Of Columbia University In The City Of New York | Preparation Of Ginkgolide And F-Seco-Ginkgolide Lactols |
| WO2007002410A2 (en) * | 2005-06-22 | 2007-01-04 | The Trustees Of Columbia University In The City Of New York | Core-modified terpene trilactones from ginkgo biloba extract and biological evaluation thereof |
| CN100462006C (zh) * | 2006-02-21 | 2009-02-18 | 复旦大学 | 银杏酸在制备杀灭钉螺、防止血吸虫病的生物农药中的用途 |
| CN102199159B (zh) * | 2011-03-21 | 2013-07-03 | 贵州大学 | 从银杏根皮中分离、纯化银杏内酯c的方法 |
| JP5461614B2 (ja) | 2011-05-31 | 2014-04-02 | 株式会社Ｔｂｍ | 無機物質粉末高配合薄膜シートの製造方法 |
| CN103396421B (zh) * | 2013-08-21 | 2016-03-30 | 上海信谊百路达药业有限公司 | 一种银杏内酯c的分离纯化方法 |
| CN103524526B (zh) * | 2013-10-15 | 2016-05-25 | 上海信谊百路达药业有限公司 | 一种白果内酯的分离纯化方法 |
| CN104034826B (zh) * | 2014-07-08 | 2015-12-02 | 上海信谊百路达药业有限公司 | 一种银杏叶提取物中萜类内酯的检测方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2117429C3 (de) * | 1971-04-08 | 1982-04-01 | Fa. Dr. Willmar Schwabe, 7500 Karlsruhe | Verfahren zur Herstellung eines Injektions- bzw. Infusionspräparates mit einem Gehalt an einem Wirkstoffgemisch aus den Blättern von Ginkgo biloba |
| FR2627387B1 (fr) | 1988-02-24 | 1992-06-05 | Fabre Sa Pierre | Procede d'obtention d'un extrait de feuilles de ginkgo biloba |
| DE3940094A1 (de) * | 1989-12-04 | 1991-06-06 | Montana Ltd | Wirkstoffkonzentrate und neue wirkstoff-kombinationen aus blaettern von ginkgo biloba, ein verfahren zu ihrer herstellung und die wirkstoff-konzentrate bzw. die wirkstoff-kombinationen enthaltenden arzneimittel |
| DE3940091A1 (de) | 1989-12-04 | 1991-06-06 | Schwabe Willmar Gmbh & Co | Extrakt aus blaettern von ginkgo biloba, verfahren zu seiner herstellung und den extrakt enthaltende arzneimittel |
| DE4030758A1 (de) | 1990-09-28 | 1992-04-02 | Schwabe Willmar Gmbh & Co | Extrakt aus blaettern von ginkgo biloba, insbesondere zur intravenoesen injektion oder infusion, verfahren zu seiner herstellung und den extrakt enthaltende ampullenpraeparate |
| KR930002507A (ko) * | 1991-07-18 | 1993-02-23 | 김영중 | 식물세포 배양법에 의한 징콜라이드류의 제조방법 |
| US6274621B1 (en) * | 1995-11-09 | 2001-08-14 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Ginkgolides for inhibition of membrane expression of benzodiazepine receptors |
| US6221356B1 (en) | 1996-12-13 | 2001-04-24 | Viva America Marketing, Inc. | Method of preparation of biologically active Ginkgo biloba product |
| FR2763592B1 (fr) | 1997-05-20 | 1999-07-16 | Sod Conseils Rech Applic | Nouveaux derives glycosyles des ginkgolides, leur application en tant que medicaments et compositions pharmaceutiques les contenant |
| EP1033994A4 (de) * | 1997-11-25 | 2002-04-03 | Pharmanex Inc | Verfahren zur herstellung von bioginkgo |
| DE19756848C2 (de) * | 1997-12-19 | 2003-01-16 | Schwabe Willmar Gmbh & Co | Extrakte aus Blättern von Ginkgo biloba mit vermindertem Gehalt an 4'-O-Methylpyridoxin und Biflavonen |
| US6030621A (en) * | 1998-03-19 | 2000-02-29 | De Long; Xie | Ginkgo biloba composition, method to prepare the same and uses thereof |
| US6117431A (en) | 1999-12-03 | 2000-09-12 | Pharmline Inc. | Method for obtaining an extract from ginkgo biloba leaves |
| FR2823116B1 (fr) | 2001-04-10 | 2004-11-19 | Sod Conseils Rech Applic | Procede de preparation d'une extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs |
| US6590109B2 (en) | 2001-07-11 | 2003-07-08 | The Trustees Of Columbia University In The City Of New York | Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba |
| US6693091B2 (en) * | 2002-03-29 | 2004-02-17 | The Trustees Of Columbia University In The City Of New York | Analogs of terpene trilactones from Ginkgo biloba for bioorganic and imaging studies |
-
2002
- 2002-07-11 US US10/194,089 patent/US6590109B2/en not_active Expired - Fee Related
- 2002-07-11 EP EP02748132A patent/EP1416949B1/de not_active Expired - Lifetime
- 2002-07-11 WO PCT/US2002/022101 patent/WO2003006040A1/en active IP Right Grant
- 2002-07-11 DE DE60215671T patent/DE60215671T2/de not_active Expired - Lifetime
- 2002-07-11 CA CA002453467A patent/CA2453467A1/en not_active Abandoned
- 2002-07-11 AT AT02748132T patent/ATE343393T1/de not_active IP Right Cessation
- 2002-07-11 KR KR10-2004-7000510A patent/KR20040031772A/ko not_active Application Discontinuation
-
2003
- 2003-07-07 US US10/615,346 patent/US6844451B2/en not_active Expired - Fee Related
-
2004
- 2004-11-01 HK HK04108587A patent/HK1065939A1/xx not_active IP Right Cessation
-
2005
- 2005-01-14 US US11/036,409 patent/US20050136136A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20030031736A1 (en) | 2003-02-13 |
| US20050136136A1 (en) | 2005-06-23 |
| EP1416949A4 (de) | 2005-11-16 |
| CA2453467A1 (en) | 2003-01-23 |
| ATE343393T1 (de) | 2006-11-15 |
| DE60215671T2 (de) | 2007-09-06 |
| US20040077883A1 (en) | 2004-04-22 |
| EP1416949B1 (de) | 2006-10-25 |
| EP1416949A1 (de) | 2004-05-12 |
| HK1065939A1 (en) | 2005-03-11 |
| US6844451B2 (en) | 2005-01-18 |
| WO2003006040A1 (en) | 2003-01-23 |
| US6590109B2 (en) | 2003-07-08 |
| KR20040031772A (ko) | 2004-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |