KR20040015206A - 코르티코트로핀 방출 인자 (crf)의 길항제로서의 접합피리미딘 - Google Patents
코르티코트로핀 방출 인자 (crf)의 길항제로서의 접합피리미딘 Download PDFInfo
- Publication number
- KR20040015206A KR20040015206A KR10-2003-7014160A KR20037014160A KR20040015206A KR 20040015206 A KR20040015206 A KR 20040015206A KR 20037014160 A KR20037014160 A KR 20037014160A KR 20040015206 A KR20040015206 A KR 20040015206A
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- South Korea
- Prior art keywords
- methyl
- dihydro
- formula
- compound
- pyrrolo
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
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- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0465—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0110570.9 | 2001-04-30 | ||
GB0110567A GB0110567D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0110569.1 | 2001-04-30 | ||
GB0110570A GB0110570D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0110567.5 | 2001-04-30 | ||
GB0110569A GB0110569D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0117420.0 | 2001-07-17 | ||
GB0117420A GB0117420D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117401.0 | 2001-07-17 | ||
GB0117399A GB0117399D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117399.6 | 2001-07-17 | ||
GB0117401A GB0117401D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0203201A GB0203201D0 (en) | 2002-02-11 | 2002-02-11 | Chemical compounds |
GB0203201.9 | 2002-02-11 | ||
GB0206834A GB0206834D0 (en) | 2002-03-22 | 2002-03-22 | Chemical compounds |
GB0206834.4 | 2002-03-22 | ||
PCT/GB2002/002029 WO2002088095A1 (en) | 2001-04-30 | 2002-04-30 | Fused pyrimidines as antagonists of the corticotropin releasing factor (crf) |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20040015206A true KR20040015206A (ko) | 2004-02-18 |
Family
ID=27571152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR10-2003-7014160A KR20040015206A (ko) | 2001-04-30 | 2002-04-30 | 코르티코트로핀 방출 인자 (crf)의 길항제로서의 접합피리미딘 |
Country Status (19)
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1395591B1 (en) * | 2001-06-12 | 2008-06-04 | Glaxo Group Limited | Corticotropin releasing factor antagonists |
GB0117396D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
WO2004062665A1 (en) * | 2003-01-16 | 2004-07-29 | Sb Pharmco Puerto Rico Inc | Heteroaryl- substituted pyrrolo` 2, 3- b! pyridine derivatives as crf receptor antagonists |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
AU2004235907B2 (en) * | 2003-05-05 | 2007-08-30 | F. Hoffmann La-Roche Ag | Fused pyrimidine derivatives with CRF activity |
ATE374190T1 (de) | 2003-08-12 | 2007-10-15 | Hoffmann La Roche | Tetrahydrochinazolinderivate als cfr-antagonisten |
CN1835753A (zh) | 2003-08-12 | 2006-09-20 | 弗·哈夫曼-拉罗切有限公司 | 作为促皮质释放素(cfr)拮抗剂的螺-取代的四氢喹唑啉 |
RU2394035C2 (ru) * | 2003-12-22 | 2010-07-10 | Эс Би ФАРМКО ПУЭРТО РИКО ИНК. | Антагонисты crf-рецепторов и способы, относящиеся к ним |
CA2552598A1 (en) * | 2004-01-06 | 2005-07-21 | Taisho Pharmaceutical Co., Ltd. | Thienopyrimidine and thienopyridine derivatives substituted with cyclic amino group |
CN1926140A (zh) * | 2004-03-05 | 2007-03-07 | 大正制药株式会社 | 吡咯并嘧啶衍生物 |
RU2389731C2 (ru) | 2004-06-02 | 2010-05-20 | Такеда Фармасьютикал Компани Лимитед | Конденсированное гетероциклическое соединение |
US20070293670A1 (en) * | 2004-06-25 | 2007-12-20 | Taisho Pharmaceutical Co., Ltd. | Pyrrolopyrimidine and Pyrrolopyridine Derivatives Substituted with Tetrahydropyridine as Crf Antagonists |
EP1802621B1 (en) * | 2004-10-19 | 2009-05-06 | SmithKline Beecham (Cork) Limited | Crf receptor antagonists and methods relating thereto |
GB0519957D0 (en) * | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
US8088779B2 (en) * | 2005-09-30 | 2012-01-03 | Smithkline Beecham (Cork) Limited | Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists |
DE602007011628D1 (de) | 2006-07-06 | 2011-02-10 | Array Biopharma Inc | Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren |
US8063050B2 (en) * | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
AU2007269052B2 (en) * | 2006-07-06 | 2014-10-23 | Array Biopharma Inc. | Cyclopenta [D] pyrimidines as AKT protein kinase inhibitors |
SI2054418T1 (sl) | 2006-07-06 | 2012-02-29 | Array Biopharma Inc | Dihidrotieno pirimidini kot AKT protein kinazni inhibitorji |
WO2008008895A1 (en) * | 2006-07-13 | 2008-01-17 | Smithkline Beecham Corporation | Gpr119 agonists for the treatment of diabetes and related disorders |
DE102007004303A1 (de) | 2006-08-04 | 2008-02-07 | Osram Opto Semiconductors Gmbh | Dünnfilm-Halbleiterbauelement und Bauelement-Verbund |
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EP1383747B1 (en) | 2008-02-20 |
DE60225127T2 (de) | 2009-02-19 |
HUP0304054A2 (hu) | 2004-04-28 |
IL158062A0 (en) | 2004-03-28 |
US20040176400A1 (en) | 2004-09-09 |
AU2002253357B2 (en) | 2006-08-24 |
EP1383747A1 (en) | 2004-01-28 |
NO20034836L (no) | 2003-10-29 |
AR033295A1 (es) | 2003-12-10 |
BR0209267A (pt) | 2004-06-15 |
CA2446514A1 (en) | 2002-11-07 |
PL366934A1 (en) | 2005-02-07 |
JP2004528349A (ja) | 2004-09-16 |
NO20034836D0 (no) | 2003-10-29 |
MXPA03009938A (es) | 2005-09-07 |
US7279474B2 (en) | 2007-10-09 |
ES2301633T3 (es) | 2008-07-01 |
DE60225127D1 (en) | 2008-04-03 |
ATE386727T1 (de) | 2008-03-15 |
CN1649848A (zh) | 2005-08-03 |
CZ20032946A3 (en) | 2004-05-12 |
WO2002088095A1 (en) | 2002-11-07 |
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