KR20030032060A - 심부정맥의 치료에 유용한 신규 옥사비스피딘 화합물 - Google Patents

심부정맥의 치료에 유용한 신규 옥사비스피딘 화합물 Download PDF

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Publication number
KR20030032060A
KR20030032060A KR10-2003-7004638A KR20037004638A KR20030032060A KR 20030032060 A KR20030032060 A KR 20030032060A KR 20037004638 A KR20037004638 A KR 20037004638A KR 20030032060 A KR20030032060 A KR 20030032060A
Authority
KR
South Korea
Prior art keywords
compound
added
solution
oxa
diazabicyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR10-2003-7004638A
Other languages
English (en)
Korean (ko)
Inventor
마그누스 뵈르스네
데이비드 클라딩보엘
프리티오프 폰텐
게르트 스트란드룬트
Original Assignee
아스트라제네카 아베
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/SE2000/001994 external-priority patent/WO2001028992A2/en
Application filed by 아스트라제네카 아베 filed Critical 아스트라제네카 아베
Publication of KR20030032060A publication Critical patent/KR20030032060A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR10-2003-7004638A 2000-10-02 2001-10-01 심부정맥의 치료에 유용한 신규 옥사비스피딘 화합물 Withdrawn KR20030032060A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PH12000002701 2000-10-02
PH1-2000-02701 2000-10-02
PCT/SE2000/001994 WO2001028992A2 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias
SEPCT/SE00/01994 2000-10-13
PCT/SE2001/002129 WO2002028863A1 (en) 2000-10-02 2001-10-01 New oxabispidine compound useful in the treatment of cardiac arrhythmias

Publications (1)

Publication Number Publication Date
KR20030032060A true KR20030032060A (ko) 2003-04-23

Family

ID=52573779

Family Applications (2)

Application Number Title Priority Date Filing Date
KR10-2003-7004638A Withdrawn KR20030032060A (ko) 2000-10-02 2001-10-01 심부정맥의 치료에 유용한 신규 옥사비스피딘 화합물
KR1020037004639A Expired - Fee Related KR100812920B1 (ko) 2000-10-02 2001-10-01 옥사비스피딘 제조를 위한 신규 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020037004639A Expired - Fee Related KR100812920B1 (ko) 2000-10-02 2001-10-01 옥사비스피딘 제조를 위한 신규 방법

Country Status (22)

Country Link
US (5) US6936712B1 (https=)
EP (3) EP1330462A1 (https=)
JP (2) JP4248873B2 (https=)
KR (2) KR20030032060A (https=)
CN (3) CN1468244A (https=)
AR (1) AR030756A1 (https=)
AU (3) AU2001292504B2 (https=)
BR (2) BR0114366A (https=)
CA (2) CA2422810A1 (https=)
CZ (1) CZ294217B6 (https=)
EE (1) EE200300131A (https=)
HU (1) HUP0302288A3 (https=)
IL (3) IL154803A0 (https=)
IS (1) IS6744A (https=)
MX (2) MXPA03002759A (https=)
NO (2) NO20031414L (https=)
NZ (2) NZ524573A (https=)
PL (1) PL364047A1 (https=)
RU (1) RU2003107668A (https=)
SK (1) SK3862003A3 (https=)
WO (2) WO2002028863A1 (https=)
ZA (2) ZA200301757B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
JP2008543750A (ja) * 2005-06-13 2008-12-04 アストラゼネカ アクチボラグ 心不整脈の処置用の新規オキサビスピジン化合物
US20100222335A1 (en) * 2005-06-20 2010-09-02 Astrazeneca Ab Process For The Preparation Of N,N'-Disubstituted Oxabispidines
WO2006137772A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab New physical form of n,n´- disubstituted oxabispidines
CA2610093A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the preparation of sulfonic acid salts of oxabispidines
AR054391A1 (es) * 2005-06-20 2007-06-20 Astrazeneca Ab Procedimiento para la preparacion de 3,7- dihidroxi-1,5-diazaciclooctanos
CN103319423B (zh) * 2013-06-28 2015-10-28 江苏师范大学 一种3,7-双芳基-1,5-二氧-3,7-二氮杂环辛烷的合成方法
KR20150082070A (ko) 2014-01-06 2015-07-15 (주)신비넷 위치 인식 시스템 및 그 시스템에서의 위치 인식을 위한 장치 및 방법
EP3059229A1 (en) 2015-02-17 2016-08-24 Evonik Degussa GmbH Method for the epoxidation of an olefin with hydrogen peroxide
CN115054728B (zh) * 2022-07-18 2023-11-07 中国科学院大学宁波华美医院 一种仿生骨组织工程支架材料及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3503939A (en) * 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
DE2428792A1 (de) * 1974-06-14 1976-01-02 Knoll Ag Neue antiarrhythmika
DE3112055A1 (de) * 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
DE3234697A1 (de) * 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue diazabicyclo-(3,3,1)-nonane
DE3732094A1 (de) * 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
DE3902357A1 (de) 1989-01-27 1990-08-02 Hoechst Ag Verwendung von rheniumorganischen verbindungen zur oxidation von c-c-mehrfachbindungen, darauf basierende oxidationsverfahren und neue rheniumorganische verbindungen
US5140033A (en) * 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) * 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5468858A (en) * 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
US5831099A (en) * 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
US5939568A (en) 1997-01-31 1999-08-17 The Scripps Research Institute Accelerated catalysis of olefinic epoxidations
SE9704709D0 (sv) 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
CZ20013608A3 (cs) * 1999-04-09 2002-05-15 Astrazeneca Ab Adamantanové deriváty
AUPQ274199A0 (en) 1999-09-09 1999-09-30 Ericsson Australia Pty Ltd Information transmission rate control across a core network
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate

Also Published As

Publication number Publication date
EP1900741A1 (en) 2008-03-19
CN1468244A (zh) 2004-01-14
PL364047A1 (en) 2004-12-13
CN1468245A (zh) 2004-01-14
US20090240051A1 (en) 2009-09-24
MXPA03002759A (es) 2003-07-28
US20090036675A1 (en) 2009-02-05
WO2002028863A1 (en) 2002-04-11
IL154803A0 (en) 2003-10-31
SK3862003A3 (en) 2003-10-07
JP2004510776A (ja) 2004-04-08
ZA200301757B (en) 2004-02-05
CA2421776A1 (en) 2002-04-11
NZ524574A (en) 2004-11-26
BR0114367A (pt) 2003-12-09
AU2001292504B2 (en) 2006-09-07
KR20030032061A (ko) 2003-04-23
HUP0302288A2 (hu) 2003-10-28
EP1900741A8 (en) 2010-08-04
IL154802A0 (en) 2003-10-31
US20040039199A1 (en) 2004-02-26
NO20031414L (no) 2003-05-26
US6936712B1 (en) 2005-08-30
RU2003107668A (ru) 2004-11-27
NO20031414D0 (no) 2003-03-27
US20050171100A1 (en) 2005-08-04
BR0114366A (pt) 2003-08-12
AR030756A1 (es) 2003-09-03
IS6744A (is) 2003-03-13
CA2422810A1 (en) 2002-04-11
JP4248873B2 (ja) 2009-04-02
EP1330462A1 (en) 2003-07-30
WO2002028863A8 (en) 2003-06-05
ZA200302202B (en) 2004-06-28
JP2004510775A (ja) 2004-04-08
NO20031413L (no) 2003-05-22
KR100812920B1 (ko) 2008-03-11
IL154803A (en) 2008-03-20
CZ2003923A3 (cs) 2003-08-13
NO20031413D0 (no) 2003-03-27
HUP0302288A3 (en) 2004-11-29
MXPA03002679A (es) 2003-06-24
CZ294217B6 (cs) 2004-10-13
AU9250401A (en) 2002-04-15
NZ524573A (en) 2004-11-26
US7439355B2 (en) 2008-10-21
EE200300131A (et) 2003-06-16
EP1330461A1 (en) 2003-07-30
CN1243754C (zh) 2006-03-01
CN1793146A (zh) 2006-06-28
AU2001292503A1 (en) 2002-04-15
WO2002028864A1 (en) 2002-04-11

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20030401

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid