KR20010102428A - 인자 ｘａ 억제제로서의 피라졸-３-온 유도체 - Google Patents

인자 ｘａ 억제제로서의 피라졸-３-온 유도체 Download PDF

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Publication number
KR20010102428A
KR20010102428A KR1020017011000A KR20017011000A KR20010102428A KR 20010102428 A KR20010102428 A KR 20010102428A KR 1020017011000 A KR1020017011000 A KR 1020017011000A KR 20017011000 A KR20017011000 A KR 20017011000A KR 20010102428 A KR20010102428 A KR 20010102428A
Authority
KR
South Korea
Prior art keywords
formula
ylmethyl
compound
phenyl
isopropyl
Prior art date
Application number
KR1020017011000A
Other languages
English (en)
Korean (ko)
Inventor
도르쉬디터
유라스지크호르스트
메데르스키베르너
차클라키디스크리스토스
부르지거한스
베르노타트-다니엘로프스키자비네
멜쩨르귀도
Original Assignee
플레믹 크리스티안
메르크 파텐트 게엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 플레믹 크리스티안, 메르크 파텐트 게엠베하 filed Critical 플레믹 크리스티안
Publication of KR20010102428A publication Critical patent/KR20010102428A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020017011000A 1999-03-03 2000-02-29 인자 ｘａ 억제제로서의 피라졸-３-온 유도체 KR20010102428A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19909237.0 1999-03-03
DE19909237A DE19909237A1 (de) 1999-03-03 1999-03-03 Pyrazol-3-on-derivate
PCT/EP2000/001695 WO2000051989A1 (de) 1999-03-03 2000-02-29 Pyrazol-3-on-derivate als faktor xa inhibitoren

Publications (1)

Publication Number Publication Date
KR20010102428A true KR20010102428A (ko) 2001-11-15

Family

ID=7899522

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017011000A KR20010102428A (ko) 1999-03-03 2000-02-29 인자 ｘａ 억제제로서의 피라졸-３-온 유도체

Country Status (17)

Country Link
EP (1) EP1157010A1 (de)
JP (1) JP2002538143A (de)
KR (1) KR20010102428A (de)
CN (1) CN1342148A (de)
AU (1) AU2916500A (de)
BR (1) BR0008608A (de)
CA (1) CA2364908A1 (de)
CZ (1) CZ20013164A3 (de)
DE (1) DE19909237A1 (de)
HU (1) HUP0200242A3 (de)
MX (1) MXPA01008844A (de)
NO (1) NO20014234L (de)
PL (1) PL350941A1 (de)
RU (1) RU2001126566A (de)
SK (1) SK12152001A3 (de)
WO (1) WO2000051989A1 (de)
ZA (1) ZA200108064B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455525B1 (en) 1999-11-04 2002-09-24 Cephalon, Inc. Heterocyclic substituted pyrazolones
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
JPWO2005012255A1 (ja) * 2003-08-01 2006-09-14 三菱ウェルファーマ株式会社 炎症性関節疾患の治療剤
DE102008020113A1 (de) 2008-04-23 2009-10-29 Bayer Schering Pharma Aktiengesellschaft Substituierte Dihydropyrazolone und ihre Verwendung
DE102005019712A1 (de) 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone und ihre Verwendung
DE102006050513A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substitiuierte Dihydropyrazolone und ihre Verwendung
DE102006050516A1 (de) * 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dihydropyrazolone und ihre Verwendung
DE102006050515A1 (de) 2006-10-26 2008-04-30 Bayer Healthcare Ag Substituierte Dipyridiyl-dihydropyrazolone und ihre Verwendung
DE102007044032A1 (de) 2007-09-14 2009-03-19 Bayer Healthcare Ag Substituierte heterocyclische Verbindungen und ihre Verwendung
DE102007048447A1 (de) 2007-10-10 2009-04-16 Bayer Healthcare Ag Substituierte Dihydropyrazolthione und ihre Verwendung
DE102010044131A1 (de) 2010-11-18 2012-05-24 Bayer Schering Pharma Aktiengesellschaft Substituiertes Natrium-1H-pyrazol-5-olat

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612353A (en) * 1995-06-07 1997-03-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
JP3994453B2 (ja) * 1995-10-13 2007-10-17 日産化学工業株式会社 ピラゾロン類

Also Published As

Publication number Publication date
ZA200108064B (en) 2003-01-02
RU2001126566A (ru) 2004-02-27
AU2916500A (en) 2000-09-21
CN1342148A (zh) 2002-03-27
CA2364908A1 (en) 2000-09-08
PL350941A1 (en) 2003-02-24
NO20014234L (no) 2001-10-24
HUP0200242A3 (en) 2002-12-28
EP1157010A1 (de) 2001-11-28
DE19909237A1 (de) 2000-09-07
JP2002538143A (ja) 2002-11-12
SK12152001A3 (sk) 2002-03-05
NO20014234D0 (no) 2001-08-31
HUP0200242A2 (hu) 2002-11-28
WO2000051989A1 (de) 2000-09-08
BR0008608A (pt) 2002-01-02
MXPA01008844A (es) 2002-05-14
CZ20013164A3 (cs) 2001-12-12

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Legal Events

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