KR20010034487A - 섬유 혹의 hi 루프내에 이종성 펩타이드 에피토프를함유하는 아데노바이러스 벡터 - Google Patents

섬유 혹의 hi 루프내에 이종성 펩타이드 에피토프를함유하는 아데노바이러스 벡터 Download PDF

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Publication number
KR20010034487A
KR20010034487A KR1020007008593A KR20007008593A KR20010034487A KR 20010034487 A KR20010034487 A KR 20010034487A KR 1020007008593 A KR1020007008593 A KR 1020007008593A KR 20007008593 A KR20007008593 A KR 20007008593A KR 20010034487 A KR20010034487 A KR 20010034487A
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South Korea
Prior art keywords
fiber
cells
adenovirus
gene
recombinant
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KR1020007008593A
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English (en)
Korean (ko)
Inventor
쿠리엘데이비드티
크라스니크빅터엔
드미트리예프이고르
Original Assignee
피터 브이. 오`네일
유에이비 리서치 파운데이션
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Publication of KR20010034487A publication Critical patent/KR20010034487A/ko
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/14011Baculoviridae
    • C12N2710/14111Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
KR1020007008593A 1998-02-06 1999-02-05 섬유 혹의 hi 루프내에 이종성 펩타이드 에피토프를함유하는 아데노바이러스 벡터 Withdrawn KR20010034487A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7394798P 1998-02-06 1998-02-06
US60/073,947 1998-02-06
US9980198P 1998-09-10 1998-09-10
US60/099,801 1998-09-10
PCT/US1999/002549 WO1999039734A1 (en) 1998-02-06 1999-02-05 Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob

Publications (1)

Publication Number Publication Date
KR20010034487A true KR20010034487A (ko) 2001-04-25

Family

ID=26755086

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007008593A Withdrawn KR20010034487A (ko) 1998-02-06 1999-02-05 섬유 혹의 hi 루프내에 이종성 펩타이드 에피토프를함유하는 아데노바이러스 벡터

Country Status (11)

Country Link
US (1) US7297542B2 (https=)
EP (1) EP1053013A4 (https=)
JP (1) JP2002507391A (https=)
KR (1) KR20010034487A (https=)
CN (1) CN1304316A (https=)
AU (1) AU744252B2 (https=)
BR (1) BR9908613A (https=)
CA (1) CA2327545A1 (https=)
IL (1) IL137681A0 (https=)
NO (1) NO20003956L (https=)
WO (1) WO1999039734A1 (https=)

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US6395875B1 (en) * 1999-01-25 2002-05-28 Brookhaven Science Associates Llc Recombinant soluble adenovirus receptor
US7157266B2 (en) * 1999-01-25 2007-01-02 Brookhaven Science Associates Llc Structure of adenovirus bound to cellular receptor car
US7560527B1 (en) 1999-11-25 2009-07-14 Transgene S.A. Modified adenovirus fibre and uses
CN1230441C (zh) 2000-04-12 2005-12-07 安盛药业有限公司 结合整联蛋白的肽衍生物
JP3635462B2 (ja) 2000-05-31 2005-04-06 国立医薬品食品衛生研究所長 アデノウイルスベクター
JP2003534805A (ja) 2000-05-31 2003-11-25 ユニバーシティ オブ サスカチュワン 変化した親和性を有する改変ウシアデノウイルス
NO20004795D0 (no) 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
WO2003006491A2 (en) 2001-07-10 2003-01-23 Amersham Health As Peptide-based compounds for targeting intergin receptors
EP1446479B1 (en) 2001-09-29 2012-08-15 Chae-Ok Yun Recombinant adenovirus with enhanced therapeutic effect and pharmaceutical composition comprising said recombinant adenovirus
US20060228334A1 (en) * 2002-07-10 2006-10-12 Manuel Rosa-Calatrava Modified adenoviral fiber with ablated to cellular receptors
US20060281090A1 (en) * 2003-05-01 2006-12-14 University Of Washington Uw Tech Transfer- Invention Licensing Capsid-modified adenovirus vectors and methods of using the same
US7611868B2 (en) 2003-05-14 2009-11-03 Instituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Recombinant modified adenovirus fiber protein
US20070104732A1 (en) * 2003-10-24 2007-05-10 Bernard Massie Ligand-pseudoreceptor system for generation of adenoviral vectors with altered tropism
CA2552262C (en) 2004-02-02 2016-04-19 The University Of British Columbia Scodaphoresis and methods and apparatus for moving and concentrating particles
US8529744B2 (en) 2004-02-02 2013-09-10 Boreal Genomics Corp. Enrichment of nucleic acid targets
US10337054B2 (en) 2004-02-02 2019-07-02 Quantum-Si Incorporated Enrichment of nucleic acid targets
US7473418B2 (en) 2004-03-25 2009-01-06 Cell Genesys, Inc. Pan cancer oncolytic vectors and methods of use thereof
DE102004021584A1 (de) * 2004-05-03 2005-12-01 Stefan Kochanek Modifizierte virale Vektorpartikel
US7776322B2 (en) 2004-08-16 2010-08-17 Stefan Kochanek Modified viral vector particles
CA2496294A1 (en) * 2005-02-07 2006-08-07 The University Of British Columbia Apparatus and methods for concentrating and separating particles such as molecules
JP6092497B2 (ja) 2006-03-30 2017-03-08 ユニバーシティー オブ カリフォルニア 抗ctla−4抗体の限局性分泌のための方法および組成物
US7919079B2 (en) 2006-03-31 2011-04-05 Biosante Pharmaceuticals, Inc. Cancer immunotherapy compositions and methods of use
WO2008140474A1 (en) * 2006-10-26 2008-11-20 Johns Hopkins University Recombinant adenovirus vaccines
EP2238434A4 (en) 2008-02-01 2011-06-22 Univ British Columbia METHOD AND DEVICE FOR PARTICLE INTRODUCTION AND RECOVERY
WO2009137211A2 (en) * 2008-05-04 2009-11-12 University Of Maryland Biotechnology Institute Off. Of Research Admin./ Tech. Dev. Fibrous assemblies for antibody presentation, and multiplexed antigenic analysis using same
US20110256055A1 (en) 2008-12-23 2011-10-20 Ge Healthcare Limited Application of 99mtc peptide-based compound as a bone marrow imaging agent
US8877028B2 (en) 2009-04-21 2014-11-04 The University Of British Columbia System and methods for detection of particles
ES2385251B1 (es) 2009-05-06 2013-05-06 Fundació Privada Institut D'investigació Biomèdica De Bellvitge Adenovirus oncolíticos para el tratamiento del cáncer.
US9458473B2 (en) * 2010-06-29 2016-10-04 The Johns Hopkins University Compositions and methods for retargeting virus constructs
CA2742327A1 (en) 2011-05-20 2012-11-20 The University Of British Columiba Systems and methods for enhanced scoda
WO2013090806A2 (en) * 2011-12-15 2013-06-20 Washington University Porcine knob xenotype chimeric adenoviral vector for dendritic cell infection
WO2013104994A2 (en) 2012-01-13 2013-07-18 The University Of British Columbia Multiple arm apparatus and methods for separation of particles
CA3215250A1 (en) * 2012-03-13 2013-09-19 Salk Institute For Biological Studies Selective cell targeting using adenovirus and chemical dimers
WO2013166444A2 (en) 2012-05-04 2013-11-07 Boreal Genomics Corp. Biomarker analysis using scodaphoresis
AU2014236207B2 (en) 2013-03-14 2019-05-23 Salk Institute For Biological Studies Oncolytic adenovirus compositions
US9340835B2 (en) 2013-03-15 2016-05-17 Boreal Genomics Corp. Method for separating homoduplexed and heteroduplexed nucleic acids
CN104634978A (zh) * 2013-11-13 2015-05-20 长春百克生物科技股份公司 一种分型检测腺病毒中和抗体的方法以及用于分型检测腺病毒中和抗体的试剂盒
WO2016025469A1 (en) * 2014-08-11 2016-02-18 The Board Of Regents Of The University Of Texas System Prevention of muscular dystrophy by crispr/cas9-mediated gene editing
KR20250081944A (ko) 2014-09-24 2025-06-05 솔크 인스티튜트 포 바이올로지칼 스터디즈 종양 살상 바이러스 및 이의 사용방법
US11130986B2 (en) 2015-05-20 2021-09-28 Quantum-Si Incorporated Method for isolating target nucleic acid using heteroduplex binding proteins
EP4155411A1 (en) 2016-02-23 2023-03-29 Salk Institute for Biological Studies Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
EP3532082A4 (en) 2016-12-12 2020-08-26 Salk Institute for Biological Studies SYNTHETIC ADENOVIRUS TUMOR TARGETING AND THEIR USES
EP3565578A1 (en) 2016-12-21 2019-11-13 Memgen LLC Armed replication-competent oncolytic adenoviruses
MX2020000244A (es) 2017-06-27 2020-09-28 Regeneron Pharma Vectores virales recombinantes con tropismo modificado y usos de estos para la introduccion dirigida de material genetico a celulas humanas.
MX2020010499A (es) 2018-04-09 2020-10-28 Salk Inst For Biological Studi Composiciones de adenovirus oncoliticas con propiedades aumentadas de replicacion.
EP3927833A4 (en) 2019-02-21 2022-11-30 Unleash Immuno Oncolytics, Inc. ONCOLYTIC ADENOVIRAL VECTOR AND METHODS OF USE
AU2020372908A1 (en) 2019-10-29 2022-06-02 Quantum-Si Incorporated Peristaltic pumping of fluids and associated methods, systems, and devices

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US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
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AU767904B2 (en) * 1999-05-12 2003-11-27 Uab Research Foundation, The Infectivity-enhanced conditionally-replicative adenovirus and uses thereof

Also Published As

Publication number Publication date
CN1304316A (zh) 2001-07-18
IL137681A0 (en) 2001-10-31
US7297542B2 (en) 2007-11-20
NO20003956L (no) 2000-10-05
AU744252B2 (en) 2002-02-21
JP2002507391A (ja) 2002-03-12
EP1053013A1 (en) 2000-11-22
NO20003956D0 (no) 2000-08-04
AU2659599A (en) 1999-08-23
BR9908613A (pt) 2000-10-31
WO1999039734A1 (en) 1999-08-12
EP1053013A4 (en) 2004-12-22
CA2327545A1 (en) 1999-08-12
US20020081280A1 (en) 2002-06-27

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Date Code Title Description
PA0105 International application

Patent event date: 20000805

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid