CA2327545A1 - Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob - Google Patents

Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob Download PDF

Info

Publication number
CA2327545A1
CA2327545A1 CA002327545A CA2327545A CA2327545A1 CA 2327545 A1 CA2327545 A1 CA 2327545A1 CA 002327545 A CA002327545 A CA 002327545A CA 2327545 A CA2327545 A CA 2327545A CA 2327545 A1 CA2327545 A1 CA 2327545A1
Authority
CA
Canada
Prior art keywords
fiber
cells
adenovirus
gene
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002327545A
Other languages
English (en)
French (fr)
Inventor
David T. Curiel
Victor N. Krasnykh
Igor Dmitriev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UAB Research Foundation
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2327545A1 publication Critical patent/CA2327545A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA002327545A 1998-02-06 1999-02-05 Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob Abandoned CA2327545A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7394798P 1998-02-06 1998-02-06
US60/073,947 1998-02-06
US9980198P 1998-09-10 1998-09-10
US60/099,801 1998-09-10
PCT/US1999/002549 WO1999039734A1 (en) 1998-02-06 1999-02-05 Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob

Publications (1)

Publication Number Publication Date
CA2327545A1 true CA2327545A1 (en) 1999-08-12

Family

ID=26755086

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002327545A Abandoned CA2327545A1 (en) 1998-02-06 1999-02-05 Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob

Country Status (11)

Country Link
US (1) US7297542B2 (https=)
EP (1) EP1053013A4 (https=)
JP (1) JP2002507391A (https=)
KR (1) KR20010034487A (https=)
CN (1) CN1304316A (https=)
AU (1) AU744252B2 (https=)
BR (1) BR9908613A (https=)
CA (1) CA2327545A1 (https=)
IL (1) IL137681A0 (https=)
NO (1) NO20003956L (https=)
WO (1) WO1999039734A1 (https=)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395875B1 (en) * 1999-01-25 2002-05-28 Brookhaven Science Associates Llc Recombinant soluble adenovirus receptor
US7157266B2 (en) * 1999-01-25 2007-01-02 Brookhaven Science Associates Llc Structure of adenovirus bound to cellular receptor car
US7560527B1 (en) 1999-11-25 2009-07-14 Transgene S.A. Modified adenovirus fibre and uses
CN1230441C (zh) 2000-04-12 2005-12-07 安盛药业有限公司 结合整联蛋白的肽衍生物
JP3635462B2 (ja) 2000-05-31 2005-04-06 国立医薬品食品衛生研究所長 アデノウイルスベクター
JP2003534805A (ja) 2000-05-31 2003-11-25 ユニバーシティ オブ サスカチュワン 変化した親和性を有する改変ウシアデノウイルス
NO20004795D0 (no) 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
WO2003006491A2 (en) 2001-07-10 2003-01-23 Amersham Health As Peptide-based compounds for targeting intergin receptors
EP1446479B1 (en) 2001-09-29 2012-08-15 Chae-Ok Yun Recombinant adenovirus with enhanced therapeutic effect and pharmaceutical composition comprising said recombinant adenovirus
US20060228334A1 (en) * 2002-07-10 2006-10-12 Manuel Rosa-Calatrava Modified adenoviral fiber with ablated to cellular receptors
US20060281090A1 (en) * 2003-05-01 2006-12-14 University Of Washington Uw Tech Transfer- Invention Licensing Capsid-modified adenovirus vectors and methods of using the same
US7611868B2 (en) 2003-05-14 2009-11-03 Instituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Recombinant modified adenovirus fiber protein
US20070104732A1 (en) * 2003-10-24 2007-05-10 Bernard Massie Ligand-pseudoreceptor system for generation of adenoviral vectors with altered tropism
CA2552262C (en) 2004-02-02 2016-04-19 The University Of British Columbia Scodaphoresis and methods and apparatus for moving and concentrating particles
US8529744B2 (en) 2004-02-02 2013-09-10 Boreal Genomics Corp. Enrichment of nucleic acid targets
US10337054B2 (en) 2004-02-02 2019-07-02 Quantum-Si Incorporated Enrichment of nucleic acid targets
US7473418B2 (en) 2004-03-25 2009-01-06 Cell Genesys, Inc. Pan cancer oncolytic vectors and methods of use thereof
DE102004021584A1 (de) * 2004-05-03 2005-12-01 Stefan Kochanek Modifizierte virale Vektorpartikel
US7776322B2 (en) 2004-08-16 2010-08-17 Stefan Kochanek Modified viral vector particles
CA2496294A1 (en) * 2005-02-07 2006-08-07 The University Of British Columbia Apparatus and methods for concentrating and separating particles such as molecules
JP6092497B2 (ja) 2006-03-30 2017-03-08 ユニバーシティー オブ カリフォルニア 抗ｃｔｌａ−４抗体の限局性分泌のための方法および組成物
US7919079B2 (en) 2006-03-31 2011-04-05 Biosante Pharmaceuticals, Inc. Cancer immunotherapy compositions and methods of use
WO2008140474A1 (en) * 2006-10-26 2008-11-20 Johns Hopkins University Recombinant adenovirus vaccines
EP2238434A4 (en) 2008-02-01 2011-06-22 Univ British Columbia METHOD AND DEVICE FOR PARTICLE INTRODUCTION AND RECOVERY
WO2009137211A2 (en) * 2008-05-04 2009-11-12 University Of Maryland Biotechnology Institute Off. Of Research Admin./ Tech. Dev. Fibrous assemblies for antibody presentation, and multiplexed antigenic analysis using same
US20110256055A1 (en) 2008-12-23 2011-10-20 Ge Healthcare Limited Application of 99mtc peptide-based compound as a bone marrow imaging agent
US8877028B2 (en) 2009-04-21 2014-11-04 The University Of British Columbia System and methods for detection of particles
ES2385251B1 (es) 2009-05-06 2013-05-06 Fundació Privada Institut D'investigació Biomèdica De Bellvitge Adenovirus oncolíticos para el tratamiento del cáncer.
US9458473B2 (en) * 2010-06-29 2016-10-04 The Johns Hopkins University Compositions and methods for retargeting virus constructs
CA2742327A1 (en) 2011-05-20 2012-11-20 The University Of British Columiba Systems and methods for enhanced scoda
WO2013090806A2 (en) * 2011-12-15 2013-06-20 Washington University Porcine knob xenotype chimeric adenoviral vector for dendritic cell infection
WO2013104994A2 (en) 2012-01-13 2013-07-18 The University Of British Columbia Multiple arm apparatus and methods for separation of particles
CA3215250A1 (en) * 2012-03-13 2013-09-19 Salk Institute For Biological Studies Selective cell targeting using adenovirus and chemical dimers
WO2013166444A2 (en) 2012-05-04 2013-11-07 Boreal Genomics Corp. Biomarker analysis using scodaphoresis
AU2014236207B2 (en) 2013-03-14 2019-05-23 Salk Institute For Biological Studies Oncolytic adenovirus compositions
US9340835B2 (en) 2013-03-15 2016-05-17 Boreal Genomics Corp. Method for separating homoduplexed and heteroduplexed nucleic acids
CN104634978A (zh) * 2013-11-13 2015-05-20 长春百克生物科技股份公司 一种分型检测腺病毒中和抗体的方法以及用于分型检测腺病毒中和抗体的试剂盒
WO2016025469A1 (en) * 2014-08-11 2016-02-18 The Board Of Regents Of The University Of Texas System Prevention of muscular dystrophy by crispr/cas9-mediated gene editing
KR20250081944A (ko) 2014-09-24 2025-06-05 솔크 인스티튜트 포 바이올로지칼 스터디즈 종양 살상 바이러스 및 이의 사용방법
US11130986B2 (en) 2015-05-20 2021-09-28 Quantum-Si Incorporated Method for isolating target nucleic acid using heteroduplex binding proteins
EP4155411A1 (en) 2016-02-23 2023-03-29 Salk Institute for Biological Studies Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
EP3532082A4 (en) 2016-12-12 2020-08-26 Salk Institute for Biological Studies SYNTHETIC ADENOVIRUS TUMOR TARGETING AND THEIR USES
EP3565578A1 (en) 2016-12-21 2019-11-13 Memgen LLC Armed replication-competent oncolytic adenoviruses
MX2020000244A (es) 2017-06-27 2020-09-28 Regeneron Pharma Vectores virales recombinantes con tropismo modificado y usos de estos para la introduccion dirigida de material genetico a celulas humanas.
MX2020010499A (es) 2018-04-09 2020-10-28 Salk Inst For Biological Studi Composiciones de adenovirus oncoliticas con propiedades aumentadas de replicacion.
EP3927833A4 (en) 2019-02-21 2022-11-30 Unleash Immuno Oncolytics, Inc. ONCOLYTIC ADENOVIRAL VECTOR AND METHODS OF USE
AU2020372908A1 (en) 2019-10-29 2022-06-02 Quantum-Si Incorporated Peristaltic pumping of fluids and associated methods, systems, and devices

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9223084D0 (en) * 1992-11-04 1992-12-16 Imp Cancer Res Tech Compounds to target cells
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US5770442A (en) * 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
EP0866721A4 (en) * 1995-12-08 2003-06-04 Univ Alabama Birmingham Res Fo TARGET ADENOVIRAL VECTORS
AU767904B2 (en) * 1999-05-12 2003-11-27 Uab Research Foundation, The Infectivity-enhanced conditionally-replicative adenovirus and uses thereof

Also Published As

Publication number Publication date
CN1304316A (zh) 2001-07-18
IL137681A0 (en) 2001-10-31
KR20010034487A (ko) 2001-04-25
US7297542B2 (en) 2007-11-20
NO20003956L (no) 2000-10-05
AU744252B2 (en) 2002-02-21
JP2002507391A (ja) 2002-03-12
EP1053013A1 (en) 2000-11-22
NO20003956D0 (no) 2000-08-04
AU2659599A (en) 1999-08-23
BR9908613A (pt) 2000-10-31
WO1999039734A1 (en) 1999-08-12
EP1053013A4 (en) 2004-12-22
US20020081280A1 (en) 2002-06-27

Similar Documents

Publication Publication Date Title
US7297542B2 (en) Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob
JP2002507391A5 (https=)
AU684220B2 (en) Recombinant adenovirus comprising a chimeric penton base protein
AU698254B2 (en) Chimeric adenoviral fiber protein and methods of using same
Wickham et al. Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins
JP4472178B2 (ja) キメラアデノウイルス
AU734515B2 (en) A short-shafted adenoviral fiber and its use
EP1181382B1 (en) Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration
US20090098599A1 (en) Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use
Glasgow et al. An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropism
WO1997020051A2 (en) Vectors and methods for gene transfer to cells
Biermann et al. Targeting of high-capacity adenoviral vectors
US6815200B1 (en) Modified adenovirus containing a fiber replacement protein
NZ505950A (en) Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob
MXPA00007721A (en) Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob
Zerbini et al. Insertion of an exogenous domain in the adenovirus type 2 fiber globular region
WO1998041618A1 (en) Method for the purification of virus
Curiel Conditionally Replicative Adenovirus for Prostate Cancer Therapy
MXPA98004203A (en) Vectors and methods for gene transfer acelu

Legal Events

Date Code Title Description
EEER Examination request
FZDC Discontinued application reinstated
FZDE Discontinued