KR20010013656A - 향상된 상부 위장관 안전용 필름 피복 정제 - Google Patents
향상된 상부 위장관 안전용 필름 피복 정제 Download PDFInfo
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- KR20010013656A KR20010013656A KR1019997011668A KR19997011668A KR20010013656A KR 20010013656 A KR20010013656 A KR 20010013656A KR 1019997011668 A KR1019997011668 A KR 1019997011668A KR 19997011668 A KR19997011668 A KR 19997011668A KR 20010013656 A KR20010013656 A KR 20010013656A
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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Abstract
Description
Claims (10)
- 테트라사이클린, 항생물질, 철 제제, 퀴니딘(quinidine), 비스테로이드형 항염증성 약제, 알프레놀롤(alprenolol), 아스코르브산, 캅토프릴(captopril), 테오필린(theophylline), 지도부딘, 비스포스포네이트 또는 이의 혼합물로 이루어진 군으로부터 선택되는 안전 및 유효량의 활성 성분과 약학적으로 허용가능한 부형제를 함유하는 제형이 위에 전달되는 경구 제형에 있어서, 통상 타원형이고, 신속한 식도 통과 촉진, 입, 구강, 인두 및 식도에서 자극 회피를 위해 필름 피복되는 것을 특징으로 하는 제형.
- 제 1 항에 있어서, 필름 피복물이 pH 1.2 내지 5 에서 용해되는 제형.
- 제 1 항 또는 제 2 항에 있어서, 필름 피복물이 히드록시프로필메틸셀룰로스, 히드록시프로필셀룰로스, 카르복시메틸셀룰로스, 메틸셀룰로스, 에틸셀룰로스, 아크릴 수지, 폴리비닐피롤리돈 또는 젤라틴 혹은 이의 혼합물로 이루어진 군으로부터 선택되는 제형.
- 제 1 항 내지 제 3 항중 어느 한 항에 있어서, 길이가 0.23 내지 0.85 인치이고, 폭이 0.11 내지 0.4 인치이며 두께가 0.075 내지 0.3 인치인 치수로 이루어진 제형.
- 제 1 항 내지 제 4 항중 어느 한 항에 있어서, 변형 타원형 또는 캐플릿 (caplet)형인 제형.
- 제 1 항 내지 제 5 항중 어느 한 항에 있어서, 활성 성분이 브롬화엠페로늄 (emperonium), 독시사이클린, 철 제제, 염화칼륨, 퀴니딘, 비스테로이드형 항염증성 약제, 알프레놀롤, 아스코르브산, 캅토프릴, 테오필린, 지도부딘, 리세드로네이트(risedronate), 알렌드로네이트(alendronate) 또는 파미드로네이트(pamidronate) , 혹은 이의 혼합물로 이루어진 군으로부터 선택되는 제형.
- 제 1 항 내지 제 6 항중 어느 한 항에 있어서, 활성 성분이 리세드로네이트, 알렌드로네이트 또는 파미드로네이트로 이루어진 군으로부터 선택되는 제형.
- 제 1 항 내지 제 7 항중 어느 한 항에 있어서, 리세드로네이트 조성물의 0.25 % 내지 40 % 를 함유하는 제형.
- 제 1 항 내지 제 8 항중 어느 한 항에 있어서, 활성 성분의 입자 및 약제학적으로 허용가능한 부형제로 이루어진 압축 정제인 경구 제형.
- 제 1 항 내지 제 9 항중 어느 한 항에 있어서, 활성 성분의 입자 자체가 필름 피복되는 경구 제형.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4930697P | 1997-06-11 | 1997-06-11 | |
US60/049,306 | 1997-06-11 |
Publications (2)
Publication Number | Publication Date |
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KR20010013656A true KR20010013656A (ko) | 2001-02-26 |
KR100400053B1 KR100400053B1 (ko) | 2003-09-29 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR10-1999-7011668A KR100400053B1 (ko) | 1997-06-11 | 1998-06-08 | 향상된 상부 위장관 안전용 필름 피복 정제 |
Country Status (30)
Country | Link |
---|---|
US (4) | US6165513A (ko) |
EP (1) | EP0989848B1 (ko) |
JP (3) | JP5093937B2 (ko) |
KR (1) | KR100400053B1 (ko) |
CN (1) | CN1274279A (ko) |
AR (1) | AR027158A1 (ko) |
AT (1) | ATE277606T1 (ko) |
AU (1) | AU729912B2 (ko) |
BR (1) | BR9810027A (ko) |
CA (1) | CA2293815C (ko) |
CO (1) | CO4940409A1 (ko) |
DE (1) | DE69826660T2 (ko) |
DK (1) | DK0989848T3 (ko) |
ES (1) | ES2226128T3 (ko) |
HK (1) | HK1028187A1 (ko) |
HU (1) | HUP0004625A1 (ko) |
IL (2) | IL133405A0 (ko) |
MY (1) | MY127526A (ko) |
NO (1) | NO996116L (ko) |
NZ (1) | NZ503946A (ko) |
PE (1) | PE82999A1 (ko) |
PL (1) | PL337813A1 (ko) |
PT (1) | PT989848E (ko) |
RU (1) | RU2193880C2 (ko) |
SG (1) | SG108292A1 (ko) |
SK (1) | SK284690B6 (ko) |
TR (1) | TR200000111T2 (ko) |
TW (1) | TW542725B (ko) |
WO (1) | WO1998056360A2 (ko) |
ZA (1) | ZA985010B (ko) |
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