KR20000029679A - 트립타아제활성관련질병을치료하기위한화합물및조성물 - Google Patents
트립타아제활성관련질병을치료하기위한화합물및조성물 Download PDFInfo
- Publication number
- KR20000029679A KR20000029679A KR1019997000757A KR19997000757A KR20000029679A KR 20000029679 A KR20000029679 A KR 20000029679A KR 1019997000757 A KR1019997000757 A KR 1019997000757A KR 19997000757 A KR19997000757 A KR 19997000757A KR 20000029679 A KR20000029679 A KR 20000029679A
- Authority
- KR
- South Korea
- Prior art keywords
- alkylene
- compound
- formula
- hetero
- piperid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
- C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
- C07D233/12—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D233/14—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2313996P | 1996-07-30 | 1996-07-30 | |
| US60/023,139 | 1996-07-30 | ||
| US89577297A | 1997-07-17 | 1997-07-17 | |
| US8/895,772 | 1997-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20000029679A true KR20000029679A (ko) | 2000-05-25 |
Family
ID=26696778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019997000757A KR20000029679A (ko) | 1996-07-30 | 1997-07-30 | 트립타아제활성관련질병을치료하기위한화합물및조성물 |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0934293A1 (fr) |
| JP (1) | JP2001509787A (fr) |
| KR (1) | KR20000029679A (fr) |
| CN (1) | CN1073103C (fr) |
| AU (1) | AU733621B2 (fr) |
| CA (1) | CA2262542A1 (fr) |
| CZ (1) | CZ29799A3 (fr) |
| EE (1) | EE9900036A (fr) |
| FI (1) | FI990171A (fr) |
| HU (1) | HUP0003267A3 (fr) |
| LV (1) | LV12291B (fr) |
| NO (1) | NO990433L (fr) |
| NZ (1) | NZ333713A (fr) |
| PL (1) | PL331465A1 (fr) |
| SI (1) | SI9720047A (fr) |
| SK (1) | SK8599A3 (fr) |
| WO (1) | WO1998004537A1 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221914B1 (en) | 1997-11-10 | 2001-04-24 | Array Biopharma Inc. | Sulfonamide bridging compounds that inhibit tryptase activity |
| JP2002502845A (ja) * | 1998-02-06 | 2002-01-29 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | トリプターゼ阻害物質 |
| US6489327B1 (en) * | 1998-02-06 | 2002-12-03 | Max-Planck-Gesellschaft Zur Fordrungder Wisenschaften, E.V. | Tryptase inhibitors |
| CA2342855A1 (fr) * | 1998-09-04 | 2000-03-16 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Nouvelles pyranoses |
| AU777026B2 (en) * | 1999-08-10 | 2004-09-30 | Altana Pharma Ag | Novel tryptase inhibitors |
| WO2001019809A1 (fr) * | 1999-09-14 | 2001-03-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Inhibiteurs de la tryptase |
| AU1413301A (en) * | 1999-11-17 | 2001-05-30 | Sumitomo Pharmaceuticals Company, Limited | Diabetic remedy containing dipiperazine derivative |
| DE19955476A1 (de) * | 1999-11-18 | 2001-05-23 | Boehringer Ingelheim Pharma | Bis-basische Verbindungen als Tryptase-Inhibitoren, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| DE60011677T2 (de) * | 1999-12-20 | 2005-07-14 | Altana Pharma Ag | Tryptase-inhibitoren |
| ATE268322T1 (de) | 1999-12-20 | 2004-06-15 | Altana Pharma Ag | Inhibitoren der tryptase |
| US6924305B2 (en) | 2001-01-31 | 2005-08-02 | Altana Pharma Ag | Diazocine derivatives and their use as tryptase inhibitors |
| WO2002066420A2 (fr) * | 2001-02-21 | 2002-08-29 | Altana Pharma Ag | Inhibiteurs de la tryptase |
| DE60217076T2 (de) | 2001-02-21 | 2007-06-21 | Altana Pharma Ag | Tryptaseinhibitoren |
| AU2002254941B2 (en) * | 2001-03-15 | 2007-05-17 | Altana Pharma Ag | Tryptase-inhibitors |
| WO2002074732A2 (fr) * | 2001-03-15 | 2002-09-26 | Altana Pharma Ag | Inhibiteurs de la tryptase |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| KR100958552B1 (ko) | 2001-06-11 | 2010-05-17 | 제노포트 인코포레이티드 | Ｇａｂａ 유사체의 프로드러그, 이의 조성물 및 용도 |
| AU2002314165B2 (en) | 2001-06-19 | 2008-02-21 | Altana Pharma Ag | Tryptase inhibitors |
| CN102429882B (zh) | 2004-11-04 | 2015-03-25 | 什诺波特有限公司 | 加巴喷丁前体药物持续释放口服剂型 |
| TWI432188B (zh) | 2008-12-19 | 2014-04-01 | Merz Pharma Gmbh & Co Kgaa | 供治療發炎性皮膚疾病之１－胺基－烷基環己烷衍生物類 |
| CN102159201A (zh) | 2008-12-19 | 2011-08-17 | 莫茨药物股份两合公司 | 用于治疗肥大细胞介导的疾病的1-氨基-烷基环己烷衍生物 |
| FR3038605B1 (fr) | 2015-07-06 | 2018-08-24 | Universite Amiens Picardie Jules Verne | Diamines primaires vicinales associees a des motifs chelateurs de metaux et/ou de radicaux libres, actives contre les stress carbonyle et oxydant et leur utilisation |
| JP7373191B2 (ja) * | 2017-05-12 | 2023-11-02 | 国立研究開発法人理化学研究所 | クラスａ ｇｐｃｒ結合性化合物改変体 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4845242A (en) * | 1987-04-28 | 1989-07-04 | Georgia Tech Research Corporation | Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents |
| CZ289930B6 (cs) * | 1993-03-12 | 2002-04-17 | Axys Pharmaceuticals, Inc. | Arylové a heteroarylové peptidové deriváty a farmaceutické prostředky je obsahující |
| US5525623A (en) * | 1993-03-12 | 1996-06-11 | Arris Pharmaceutical Corporation | Compositions and methods for the treatment of immunomediated inflammatory disorders |
| WO1995032945A1 (fr) * | 1994-06-01 | 1995-12-07 | Arris Pharmaceutical Corporation | Compositions et procedes de traitement d'etats induits par des mastocytes |
| CN1160398A (zh) * | 1994-09-23 | 1997-09-24 | 阿瑞斯药物公司 | 治疗肥大细胞炎性疾病的组合物和方法 |
| PL322409A1 (en) * | 1995-03-24 | 1998-01-19 | Arris Pharm Corp | Reversible protease inhibitors |
| TW438591B (en) * | 1995-06-07 | 2001-06-07 | Arris Pharm Corp | Reversible cysteine protease inhibitors |
-
1997
- 1997-07-30 NZ NZ333713A patent/NZ333713A/xx unknown
- 1997-07-30 PL PL97331465A patent/PL331465A1/xx unknown
- 1997-07-30 SI SI9720047A patent/SI9720047A/sl unknown
- 1997-07-30 CZ CZ99297A patent/CZ29799A3/cs unknown
- 1997-07-30 EE EEP199900036A patent/EE9900036A/xx unknown
- 1997-07-30 KR KR1019997000757A patent/KR20000029679A/ko not_active Application Discontinuation
- 1997-07-30 HU HU0003267A patent/HUP0003267A3/hu unknown
- 1997-07-30 AU AU39670/97A patent/AU733621B2/en not_active Ceased
- 1997-07-30 CA CA002262542A patent/CA2262542A1/fr not_active Abandoned
- 1997-07-30 SK SK85-99A patent/SK8599A3/sk unknown
- 1997-07-30 CN CN97196877A patent/CN1073103C/zh not_active Expired - Fee Related
- 1997-07-30 JP JP50913698A patent/JP2001509787A/ja active Pending
- 1997-07-30 WO PCT/US1997/013422 patent/WO1998004537A1/fr not_active Application Discontinuation
- 1997-07-30 EP EP97937066A patent/EP0934293A1/fr not_active Withdrawn
-
1999
- 1999-01-29 NO NO990433A patent/NO990433L/no not_active Application Discontinuation
- 1999-01-29 FI FI990171A patent/FI990171A/fi unknown
- 1999-02-18 LV LVP-99-27A patent/LV12291B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2262542A1 (fr) | 1998-02-05 |
| CN1226892A (zh) | 1999-08-25 |
| SI9720047A (sl) | 1999-08-31 |
| LV12291B (en) | 2000-04-20 |
| FI990171A0 (fi) | 1999-01-29 |
| CN1073103C (zh) | 2001-10-17 |
| PL331465A1 (en) | 1999-07-19 |
| AU3967097A (en) | 1998-02-20 |
| AU733621B2 (en) | 2001-05-17 |
| HUP0003267A3 (en) | 2002-02-28 |
| FI990171A (fi) | 1999-03-23 |
| NO990433D0 (no) | 1999-01-29 |
| EE9900036A (et) | 1999-08-16 |
| HUP0003267A2 (hu) | 2001-06-28 |
| JP2001509787A (ja) | 2001-07-24 |
| EP0934293A1 (fr) | 1999-08-11 |
| WO1998004537A1 (fr) | 1998-02-05 |
| NZ333713A (en) | 2000-12-22 |
| LV12291A (lv) | 1999-06-20 |
| CZ29799A3 (cs) | 1999-06-16 |
| SK8599A3 (en) | 2000-03-13 |
| NO990433L (no) | 1999-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |