KR19980081287A - 융합 피페리딘 화합물 - Google Patents
융합 피페리딘 화합물 Download PDFInfo
- Publication number
- KR19980081287A KR19980081287A KR1019980012758A KR19980012758A KR19980081287A KR 19980081287 A KR19980081287 A KR 19980081287A KR 1019980012758 A KR1019980012758 A KR 1019980012758A KR 19980012758 A KR19980012758 A KR 19980012758A KR 19980081287 A KR19980081287 A KR 19980081287A
- Authority
- KR
- South Korea
- Prior art keywords
- azabicyclo
- imino
- heptane
- trans
- methyl
- Prior art date
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 210000004493 neutrocyte Anatomy 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 239000012457 nonaqueous media Substances 0.000 description 1
- ZHVULPDNOFUIML-UHFFFAOYSA-N octane;hydrochloride Chemical compound Cl.CCCCCCCC ZHVULPDNOFUIML-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 125000002255 pentenyl group Chemical group C(=CCCC)* 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000005981 pentynyl group Chemical group 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
- 125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960004617 sapropterin Drugs 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 125000003003 spiro group Chemical group 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002536 stromal cell Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical group CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP97-91830 | 1997-04-10 | ||
| JP9183097 | 1997-04-10 | ||
| JP97-273196 | 1997-10-07 | ||
| JP27319697 | 1997-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR19980081287A true KR19980081287A (ko) | 1998-11-25 |
Family
ID=26433266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019980012758A KR19980081287A (ko) | 1997-04-10 | 1998-04-10 | 융합 피페리딘 화합물 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6110930A (no) |
| EP (1) | EP0870763B1 (no) |
| KR (1) | KR19980081287A (no) |
| CN (1) | CN1202486A (no) |
| AT (1) | ATE210647T1 (no) |
| AU (1) | AU746048B2 (no) |
| CA (1) | CA2234571A1 (no) |
| DE (1) | DE69802858T2 (no) |
| DK (1) | DK0870763T3 (no) |
| ES (1) | ES2169886T3 (no) |
| HU (1) | HUP9800865A3 (no) |
| NO (1) | NO310618B1 (no) |
| PT (1) | PT870763E (no) |
| TW (1) | TW427979B (no) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2793248B1 (fr) * | 1999-05-03 | 2001-06-29 | Adir | Nouveaux derives de 2,3-methano-aminoacides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1199078A1 (en) * | 1999-06-09 | 2002-04-24 | Ono Pharmaceutical Co., Ltd. | Analgesics |
| FR2794647A1 (fr) * | 1999-06-11 | 2000-12-15 | Centre Nat Rech Scient | Compositions pharmaceutique comprenant du no ou au moins un compose capable de liberer ou d'induire la formation de no dans les cellules |
| AU5566700A (en) * | 1999-06-22 | 2001-01-09 | Ono Pharmaceutical Co. Ltd. | Process for the preparation of intermediate compounds of drugs |
| FR2803298A1 (fr) * | 1999-12-30 | 2001-07-06 | Adir | Nouvelles urees lineaires ou cycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| RU2002121496A (ru) * | 2000-02-10 | 2004-03-20 | Оно Фармасьютикал Ко., Лтд. (Jp) | Средство для лечения синдрома шегрена |
| AU2001296028A1 (en) * | 2000-10-30 | 2002-05-15 | Ono Pharmaceutical Co. Ltd. | Remedies for extraocular inflammatory diseases |
| JPWO2003022309A1 (ja) * | 2001-09-10 | 2004-12-24 | 小野薬品工業株式会社 | アレルギー疾患治療剤 |
| JP2006096665A (ja) * | 2002-10-29 | 2006-04-13 | Ono Pharmaceut Co Ltd | 脊柱管狭窄症治療剤 |
| EP1626961B1 (en) * | 2003-05-17 | 2011-11-02 | Korea Research Institute of Bioscience and Biotechnology | Novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same |
| US20050234026A1 (en) * | 2003-11-10 | 2005-10-20 | Weinberg Joe B | Method and agent for inducing apoptosis/cell death in leukemia cells |
| US20090186929A1 (en) * | 2003-11-10 | 2009-07-23 | U.S. Department Of Veterans Affairs | Method and agent for inducing apoptosis/cell death in leukemia cells |
| US7364437B2 (en) * | 2005-08-04 | 2008-04-29 | Seagate Technology Llc | Electronic device housing |
| WO2008101602A2 (en) | 2007-02-19 | 2008-08-28 | Dsm Ip Assets B.V. | Catalysts containing platinum group metal nanoparticles and process for production of dispersions of nanoparticles of platinum group metal |
| WO2018035046A1 (en) | 2016-08-15 | 2018-02-22 | President And Fellows Of Harvard College | Treating infections using idsd from proteus mirabilis |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0897912A1 (en) * | 1993-10-21 | 1999-02-24 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
| US5629322A (en) * | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
| WO1996014842A1 (en) * | 1994-11-15 | 1996-05-23 | Merck & Co., Inc. | Substituted heterocycles as inhibitors of nitric oxide synthase |
| NZ307950A (en) * | 1995-05-10 | 1999-06-29 | Searle & Co | Cyclic amidines derivatives and medicaments thereof |
-
1998
- 1998-04-08 NO NO19981658A patent/NO310618B1/no not_active IP Right Cessation
- 1998-04-08 US US09/056,867 patent/US6110930A/en not_active Expired - Fee Related
- 1998-04-09 AT AT98106569T patent/ATE210647T1/de not_active IP Right Cessation
- 1998-04-09 PT PT98106569T patent/PT870763E/pt unknown
- 1998-04-09 CN CN98108834A patent/CN1202486A/zh active Pending
- 1998-04-09 DE DE69802858T patent/DE69802858T2/de not_active Expired - Fee Related
- 1998-04-09 AU AU60777/98A patent/AU746048B2/en not_active Ceased
- 1998-04-09 DK DK98106569T patent/DK0870763T3/da active
- 1998-04-09 ES ES98106569T patent/ES2169886T3/es not_active Expired - Lifetime
- 1998-04-09 EP EP98106569A patent/EP0870763B1/en not_active Expired - Lifetime
- 1998-04-09 TW TW087105329A patent/TW427979B/zh active
- 1998-04-09 CA CA002234571A patent/CA2234571A1/en not_active Abandoned
- 1998-04-10 KR KR1019980012758A patent/KR19980081287A/ko not_active Application Discontinuation
- 1998-04-10 HU HU9800865A patent/HUP9800865A3/hu unknown
-
2000
- 2000-03-13 US US09/524,255 patent/US6228866B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU6077798A (en) | 1998-10-15 |
| NO981658L (no) | 1998-10-12 |
| NO310618B1 (no) | 2001-07-30 |
| DE69802858D1 (de) | 2002-01-24 |
| EP0870763A1 (en) | 1998-10-14 |
| DE69802858T2 (de) | 2002-08-08 |
| CN1202486A (zh) | 1998-12-23 |
| US6110930A (en) | 2000-08-29 |
| DK0870763T3 (da) | 2002-03-11 |
| PT870763E (pt) | 2002-06-28 |
| ES2169886T3 (es) | 2002-07-16 |
| EP0870763B1 (en) | 2001-12-12 |
| US6228866B1 (en) | 2001-05-08 |
| ATE210647T1 (de) | 2001-12-15 |
| HUP9800865A3 (en) | 1999-03-01 |
| TW427979B (en) | 2001-04-01 |
| HU9800865D0 (en) | 1998-05-28 |
| CA2234571A1 (en) | 1998-10-10 |
| HUP9800865A2 (hu) | 1999-01-28 |
| AU746048B2 (en) | 2002-04-11 |
| NO981658D0 (no) | 1998-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |