ATE210647T1 - Kondensierte piperin-derivate als stickstoffmonoxid-synthese-hemmer - Google Patents
Kondensierte piperin-derivate als stickstoffmonoxid-synthese-hemmerInfo
- Publication number
- ATE210647T1 ATE210647T1 AT98106569T AT98106569T ATE210647T1 AT E210647 T1 ATE210647 T1 AT E210647T1 AT 98106569 T AT98106569 T AT 98106569T AT 98106569 T AT98106569 T AT 98106569T AT E210647 T1 ATE210647 T1 AT E210647T1
- Authority
- AT
- Austria
- Prior art keywords
- nitrogen monoxide
- condensed
- synthesis inhibitors
- monoxide synthesis
- piperine derivatives
- Prior art date
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical class C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9183097 | 1997-04-10 | ||
| JP27319697 | 1997-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE210647T1 true ATE210647T1 (de) | 2001-12-15 |
Family
ID=26433266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98106569T ATE210647T1 (de) | 1997-04-10 | 1998-04-09 | Kondensierte piperin-derivate als stickstoffmonoxid-synthese-hemmer |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6110930A (de) |
| EP (1) | EP0870763B1 (de) |
| KR (1) | KR19980081287A (de) |
| CN (1) | CN1202486A (de) |
| AT (1) | ATE210647T1 (de) |
| AU (1) | AU746048B2 (de) |
| CA (1) | CA2234571A1 (de) |
| DE (1) | DE69802858T2 (de) |
| DK (1) | DK0870763T3 (de) |
| ES (1) | ES2169886T3 (de) |
| HU (1) | HUP9800865A3 (de) |
| NO (1) | NO310618B1 (de) |
| PT (1) | PT870763E (de) |
| TW (1) | TW427979B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2793248B1 (fr) * | 1999-05-03 | 2001-06-29 | Adir | Nouveaux derives de 2,3-methano-aminoacides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2000074678A1 (en) * | 1999-06-09 | 2000-12-14 | Ono Pharmaceutical Co., Ltd. | Analgesics |
| FR2794647A1 (fr) * | 1999-06-11 | 2000-12-15 | Centre Nat Rech Scient | Compositions pharmaceutique comprenant du no ou au moins un compose capable de liberer ou d'induire la formation de no dans les cellules |
| WO2000078722A1 (en) * | 1999-06-22 | 2000-12-28 | Ono Pharmaceutical Co., Ltd. | Process for the preparation of intermediate compounds of drugs |
| FR2803298A1 (fr) * | 1999-12-30 | 2001-07-06 | Adir | Nouvelles urees lineaires ou cycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2001232259A1 (en) * | 2000-02-10 | 2001-08-20 | Ono Pharmaceutical Co., Ltd. | Remedies for sjoegren's syndrome |
| AU2001296028A1 (en) * | 2000-10-30 | 2002-05-15 | Ono Pharmaceutical Co. Ltd. | Remedies for extraocular inflammatory diseases |
| JPWO2003022309A1 (ja) * | 2001-09-10 | 2004-12-24 | 小野薬品工業株式会社 | アレルギー疾患治療剤 |
| JP2006096665A (ja) * | 2002-10-29 | 2006-04-13 | Ono Pharmaceut Co Ltd | 脊柱管狭窄症治療剤 |
| EP1626961B1 (de) * | 2003-05-17 | 2011-11-02 | Korea Research Institute of Bioscience and Biotechnology | Neue heterozyklische 2-oxo-verbindungen und pharmazeutische zusammensetzungen, die diese enthalten |
| KR100594377B1 (ko) * | 2003-05-17 | 2006-06-30 | 한국생명공학연구원 | 항염증 활성을 갖는 신규 2-옥소-피페리딘 유도체(ⅰ)화합물, 이의 제조방법 및 이를 포함하는 염증 질환의치료를 위한 조성물 |
| US20090186929A1 (en) * | 2003-11-10 | 2009-07-23 | U.S. Department Of Veterans Affairs | Method and agent for inducing apoptosis/cell death in leukemia cells |
| US20050234026A1 (en) * | 2003-11-10 | 2005-10-20 | Weinberg Joe B | Method and agent for inducing apoptosis/cell death in leukemia cells |
| US7364437B2 (en) * | 2005-08-04 | 2008-04-29 | Seagate Technology Llc | Electronic device housing |
| WO2008101602A2 (en) | 2007-02-19 | 2008-08-28 | Dsm Ip Assets B.V. | Catalysts containing platinum group metal nanoparticles and process for production of dispersions of nanoparticles of platinum group metal |
| WO2018035046A1 (en) | 2016-08-15 | 2018-02-22 | President And Fellows Of Harvard College | Treating infections using idsd from proteus mirabilis |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09504028A (ja) * | 1993-10-21 | 1997-04-22 | ジー.ディー.サール アンド カンパニー | 酸化窒素シンターゼ抑制剤として有用なアミジノ誘導体 |
| WO1996014842A1 (en) * | 1994-11-15 | 1996-05-23 | Merck & Co., Inc. | Substituted heterocycles as inhibitors of nitric oxide synthase |
| US5629322A (en) * | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
| MX9708631A (es) * | 1995-05-10 | 1998-02-28 | Searle & Co | Inhibidores de oxido nitrico sintetasa derivados de aminas ciclicas. |
-
1998
- 1998-04-08 US US09/056,867 patent/US6110930A/en not_active Expired - Fee Related
- 1998-04-08 NO NO19981658A patent/NO310618B1/no not_active IP Right Cessation
- 1998-04-09 CN CN98108834A patent/CN1202486A/zh active Pending
- 1998-04-09 EP EP98106569A patent/EP0870763B1/de not_active Expired - Lifetime
- 1998-04-09 PT PT98106569T patent/PT870763E/pt unknown
- 1998-04-09 DE DE69802858T patent/DE69802858T2/de not_active Expired - Fee Related
- 1998-04-09 AU AU60777/98A patent/AU746048B2/en not_active Ceased
- 1998-04-09 AT AT98106569T patent/ATE210647T1/de not_active IP Right Cessation
- 1998-04-09 ES ES98106569T patent/ES2169886T3/es not_active Expired - Lifetime
- 1998-04-09 TW TW087105329A patent/TW427979B/zh active
- 1998-04-09 CA CA002234571A patent/CA2234571A1/en not_active Abandoned
- 1998-04-09 DK DK98106569T patent/DK0870763T3/da active
- 1998-04-10 KR KR1019980012758A patent/KR19980081287A/ko not_active Ceased
- 1998-04-10 HU HU9800865A patent/HUP9800865A3/hu unknown
-
2000
- 2000-03-13 US US09/524,255 patent/US6228866B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| TW427979B (en) | 2001-04-01 |
| DE69802858T2 (de) | 2002-08-08 |
| KR19980081287A (ko) | 1998-11-25 |
| CA2234571A1 (en) | 1998-10-10 |
| NO981658D0 (no) | 1998-04-08 |
| AU746048B2 (en) | 2002-04-11 |
| HUP9800865A2 (hu) | 1999-01-28 |
| EP0870763B1 (de) | 2001-12-12 |
| ES2169886T3 (es) | 2002-07-16 |
| HUP9800865A3 (en) | 1999-03-01 |
| CN1202486A (zh) | 1998-12-23 |
| DE69802858D1 (de) | 2002-01-24 |
| EP0870763A1 (de) | 1998-10-14 |
| NO310618B1 (no) | 2001-07-30 |
| US6228866B1 (en) | 2001-05-08 |
| HU9800865D0 (en) | 1998-05-28 |
| US6110930A (en) | 2000-08-29 |
| PT870763E (pt) | 2002-06-28 |
| DK0870763T3 (da) | 2002-03-11 |
| AU6077798A (en) | 1998-10-15 |
| NO981658L (no) | 1998-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |