NO310618B1 - Kondenserte piperidinforbindelser, fremstilling og anvendelse derav, samt preparater omfattende slike forbindelser - Google Patents
Kondenserte piperidinforbindelser, fremstilling og anvendelse derav, samt preparater omfattende slike forbindelser Download PDFInfo
- Publication number
- NO310618B1 NO310618B1 NO19981658A NO981658A NO310618B1 NO 310618 B1 NO310618 B1 NO 310618B1 NO 19981658 A NO19981658 A NO 19981658A NO 981658 A NO981658 A NO 981658A NO 310618 B1 NO310618 B1 NO 310618B1
- Authority
- NO
- Norway
- Prior art keywords
- azabicyclo
- imino
- heptane
- trans
- methyl
- Prior art date
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- -1 piperidine compound Chemical class 0.000 claims description 26
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- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 125000004001 thioalkyl group Chemical group 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
- LHHPEAQVCCPLBC-UHFFFAOYSA-N tributyltin;hydrate Chemical compound O.CCCC[Sn](CCCC)CCCC LHHPEAQVCCPLBC-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9183097 | 1997-04-10 | ||
| JP27319697 | 1997-10-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO981658D0 NO981658D0 (no) | 1998-04-08 |
| NO981658L NO981658L (no) | 1998-10-12 |
| NO310618B1 true NO310618B1 (no) | 2001-07-30 |
Family
ID=26433266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19981658A NO310618B1 (no) | 1997-04-10 | 1998-04-08 | Kondenserte piperidinforbindelser, fremstilling og anvendelse derav, samt preparater omfattende slike forbindelser |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6110930A (de) |
| EP (1) | EP0870763B1 (de) |
| KR (1) | KR19980081287A (de) |
| CN (1) | CN1202486A (de) |
| AT (1) | ATE210647T1 (de) |
| AU (1) | AU746048B2 (de) |
| CA (1) | CA2234571A1 (de) |
| DE (1) | DE69802858T2 (de) |
| DK (1) | DK0870763T3 (de) |
| ES (1) | ES2169886T3 (de) |
| HU (1) | HUP9800865A3 (de) |
| NO (1) | NO310618B1 (de) |
| PT (1) | PT870763E (de) |
| TW (1) | TW427979B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2793248B1 (fr) * | 1999-05-03 | 2001-06-29 | Adir | Nouveaux derives de 2,3-methano-aminoacides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU5246000A (en) * | 1999-06-09 | 2000-12-28 | Ono Pharmaceutical Co. Ltd. | Analgesics |
| FR2794647A1 (fr) * | 1999-06-11 | 2000-12-15 | Centre Nat Rech Scient | Compositions pharmaceutique comprenant du no ou au moins un compose capable de liberer ou d'induire la formation de no dans les cellules |
| BR0011780A (pt) * | 1999-06-22 | 2002-05-21 | Ono Pharmaceutical Co | Processo para a preparação de compostos intermediários de drogas |
| FR2803298A1 (fr) * | 1999-12-30 | 2001-07-06 | Adir | Nouvelles urees lineaires ou cycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2001232259A1 (en) * | 2000-02-10 | 2001-08-20 | Ono Pharmaceutical Co., Ltd. | Remedies for sjoegren's syndrome |
| AU2001296028A1 (en) * | 2000-10-30 | 2002-05-15 | Ono Pharmaceutical Co. Ltd. | Remedies for extraocular inflammatory diseases |
| US20040235890A1 (en) * | 2001-09-10 | 2004-11-25 | Masaharu Komeno | Remedies for allergic diseases |
| JP2006096665A (ja) * | 2002-10-29 | 2006-04-13 | Ono Pharmaceut Co Ltd | 脊柱管狭窄症治療剤 |
| WO2004101523A1 (en) * | 2003-05-17 | 2004-11-25 | Korea Research Institute Of Bioscience And Biotechnology | Novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same |
| US20090186929A1 (en) * | 2003-11-10 | 2009-07-23 | U.S. Department Of Veterans Affairs | Method and agent for inducing apoptosis/cell death in leukemia cells |
| US20050234026A1 (en) * | 2003-11-10 | 2005-10-20 | Weinberg Joe B | Method and agent for inducing apoptosis/cell death in leukemia cells |
| US7364437B2 (en) * | 2005-08-04 | 2008-04-29 | Seagate Technology Llc | Electronic device housing |
| WO2008101602A2 (en) | 2007-02-19 | 2008-08-28 | Dsm Ip Assets B.V. | Catalysts containing platinum group metal nanoparticles and process for production of dispersions of nanoparticles of platinum group metal |
| WO2018035046A1 (en) | 2016-08-15 | 2018-02-22 | President And Fellows Of Harvard College | Treating infections using idsd from proteus mirabilis |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09504028A (ja) * | 1993-10-21 | 1997-04-22 | ジー．ディー．サール アンド カンパニー | 酸化窒素シンターゼ抑制剤として有用なアミジノ誘導体 |
| WO1996014842A1 (en) * | 1994-11-15 | 1996-05-23 | Merck & Co., Inc. | Substituted heterocycles as inhibitors of nitric oxide synthase |
| US5629322A (en) * | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
| CN1190390A (zh) * | 1995-05-10 | 1998-08-12 | G.D.瑟尔公司 | 由环状脒衍生的氧化氮合成酶抑制剂 |
-
1998
- 1998-04-08 NO NO19981658A patent/NO310618B1/no not_active IP Right Cessation
- 1998-04-08 US US09/056,867 patent/US6110930A/en not_active Expired - Fee Related
- 1998-04-09 ES ES98106569T patent/ES2169886T3/es not_active Expired - Lifetime
- 1998-04-09 CN CN98108834A patent/CN1202486A/zh active Pending
- 1998-04-09 TW TW087105329A patent/TW427979B/zh active
- 1998-04-09 AU AU60777/98A patent/AU746048B2/en not_active Ceased
- 1998-04-09 EP EP98106569A patent/EP0870763B1/de not_active Expired - Lifetime
- 1998-04-09 CA CA002234571A patent/CA2234571A1/en not_active Abandoned
- 1998-04-09 PT PT98106569T patent/PT870763E/pt unknown
- 1998-04-09 DK DK98106569T patent/DK0870763T3/da active
- 1998-04-09 DE DE69802858T patent/DE69802858T2/de not_active Expired - Fee Related
- 1998-04-09 AT AT98106569T patent/ATE210647T1/de not_active IP Right Cessation
- 1998-04-10 HU HU9800865A patent/HUP9800865A3/hu unknown
- 1998-04-10 KR KR1019980012758A patent/KR19980081287A/ko not_active Application Discontinuation
-
2000
- 2000-03-13 US US09/524,255 patent/US6228866B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO981658L (no) | 1998-10-12 |
| ATE210647T1 (de) | 2001-12-15 |
| CN1202486A (zh) | 1998-12-23 |
| TW427979B (en) | 2001-04-01 |
| DE69802858D1 (de) | 2002-01-24 |
| HUP9800865A2 (hu) | 1999-01-28 |
| ES2169886T3 (es) | 2002-07-16 |
| CA2234571A1 (en) | 1998-10-10 |
| NO981658D0 (no) | 1998-04-08 |
| EP0870763B1 (de) | 2001-12-12 |
| HUP9800865A3 (en) | 1999-03-01 |
| AU6077798A (en) | 1998-10-15 |
| PT870763E (pt) | 2002-06-28 |
| DE69802858T2 (de) | 2002-08-08 |
| KR19980081287A (ko) | 1998-11-25 |
| US6110930A (en) | 2000-08-29 |
| EP0870763A1 (de) | 1998-10-14 |
| HU9800865D0 (en) | 1998-05-28 |
| US6228866B1 (en) | 2001-05-08 |
| AU746048B2 (en) | 2002-04-11 |
| DK0870763T3 (da) | 2002-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN OCTOBER 2003 |