KR102889223B1 - 하이드록시티로솔을 제조하는 방법 - Google Patents

하이드록시티로솔을 제조하는 방법

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Publication number
KR102889223B1
KR102889223B1 KR1020237032804A KR20237032804A KR102889223B1 KR 102889223 B1 KR102889223 B1 KR 102889223B1 KR 1020237032804 A KR1020237032804 A KR 1020237032804A KR 20237032804 A KR20237032804 A KR 20237032804A KR 102889223 B1 KR102889223 B1 KR 102889223B1
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KR
South Korea
Prior art keywords
hts
tyrosol
oxidase
ala
val
Prior art date
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KR1020237032804A
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English (en)
Korean (ko)
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KR20230150337A (ko
Inventor
루퍼트 팔러
Original Assignee
와커 헤미 아게
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Application filed by 와커 헤미 아게 filed Critical 와커 헤미 아게
Publication of KR20230150337A publication Critical patent/KR20230150337A/ko
Application granted granted Critical
Publication of KR102889223B1 publication Critical patent/KR102889223B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0055—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10)
    • C12N9/0057—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10) with oxygen as acceptor (1.10.3)
    • C12N9/0059—Catechol oxidase (1.10.3.1), i.e. tyrosinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y110/00—Oxidoreductases acting on diphenols and related substances as donors (1.10)
    • C12Y110/03—Oxidoreductases acting on diphenols and related substances as donors (1.10) with an oxygen as acceptor (1.10.3)
    • C12Y110/03001—Catechol oxidase (1.10.3.1), i.e. tyrosinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020237032804A 2021-03-03 2021-03-03 하이드록시티로솔을 제조하는 방법 Active KR102889223B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2021/055378 WO2022184255A1 (de) 2021-03-03 2021-03-03 Verfahren zur herstellung von hydroxytyrosol

Publications (2)

Publication Number Publication Date
KR20230150337A KR20230150337A (ko) 2023-10-30
KR102889223B1 true KR102889223B1 (ko) 2025-11-20

Family

ID=74870796

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020237032804A Active KR102889223B1 (ko) 2021-03-03 2021-03-03 하이드록시티로솔을 제조하는 방법

Country Status (6)

Country Link
US (1) US20240200107A1 (https=)
EP (1) EP4301864A1 (https=)
JP (1) JP7757412B2 (https=)
KR (1) KR102889223B1 (https=)
CN (1) CN116964211A (https=)
WO (1) WO2022184255A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12564564B2 (en) 2024-07-22 2026-03-03 MolTek Nutrition Co., Ltd Composition comprising tyrosol and amino acids and its application in enhancing athletic performance and combating fatigue

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008064839A2 (en) 2006-11-27 2008-06-05 Dsm Ip Assets B.V. Method for preparing hydroxytyrosol
CN101624607A (zh) 2009-08-03 2010-01-13 山东省巨野晨农天然产物有限公司 一种羟基酪醇的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2170006B1 (es) * 2000-08-11 2003-11-01 Consejo Superior Investigacion Sintesis enzimatica del antioxidante hidroxitirosol.
TNSN03042A1 (fr) 2003-07-23 2005-04-08 Ct De Biotechnologie De Sfax Cbs Procede d'extraction en continu et de purification de l'hydroxytyrosol.
ITMI20070519A1 (it) * 2007-03-15 2008-09-16 Maurizio Barontini Procedimento per la preparazione di derivati dell'idrossitirosolo e di idrossitirosolo
JP2010255647A (ja) * 2009-04-21 2010-11-11 Ntn Corp クロスグルーブ型等速自在継手
DE102011003387A1 (de) 2011-01-31 2012-08-02 Wacker Chemie Ag Verfahren zur fermentativen Herstellung von 2,3-Butandiol
DE102013203753A1 (de) 2013-03-05 2014-09-11 Wacker Chemie Ag Verfahren zur Herstellung von Hydroxytyrosol
PT3234164T (pt) * 2014-12-17 2019-05-30 Univ College Dublin Nat Univ Ireland Dublin Método para a conversão enzimática de um substrato fenólico num correspondente produto catecol

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008064839A2 (en) 2006-11-27 2008-06-05 Dsm Ip Assets B.V. Method for preparing hydroxytyrosol
CN101624607A (zh) 2009-08-03 2010-01-13 山东省巨野晨农天然产物有限公司 一种羟基酪醇的制备方法

Also Published As

Publication number Publication date
US20240200107A1 (en) 2024-06-20
JP2024509162A (ja) 2024-02-29
WO2022184255A1 (de) 2022-09-09
JP7757412B2 (ja) 2025-10-21
KR20230150337A (ko) 2023-10-30
EP4301864A1 (de) 2024-01-10
CN116964211A (zh) 2023-10-27

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