JP7757412B2 - ヒドロキシチロソールの製造方法 - Google Patents

ヒドロキシチロソールの製造方法

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Publication number
JP7757412B2
JP7757412B2 JP2023553453A JP2023553453A JP7757412B2 JP 7757412 B2 JP7757412 B2 JP 7757412B2 JP 2023553453 A JP2023553453 A JP 2023553453A JP 2023553453 A JP2023553453 A JP 2023553453A JP 7757412 B2 JP7757412 B2 JP 7757412B2
Authority
JP
Japan
Prior art keywords
hts
tyrosol
oxidase
amino acid
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2023553453A
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English (en)
Japanese (ja)
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JP2024509162A (ja
JP2024509162A5 (https=
Inventor
ルーペルト、プファラー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wacker Chemie AG
Original Assignee
Wacker Chemie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wacker Chemie AG filed Critical Wacker Chemie AG
Publication of JP2024509162A publication Critical patent/JP2024509162A/ja
Publication of JP2024509162A5 publication Critical patent/JP2024509162A5/ja
Application granted granted Critical
Publication of JP7757412B2 publication Critical patent/JP7757412B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0055—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10)
    • C12N9/0057—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10) with oxygen as acceptor (1.10.3)
    • C12N9/0059—Catechol oxidase (1.10.3.1), i.e. tyrosinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y110/00—Oxidoreductases acting on diphenols and related substances as donors (1.10)
    • C12Y110/03—Oxidoreductases acting on diphenols and related substances as donors (1.10) with an oxygen as acceptor (1.10.3)
    • C12Y110/03001—Catechol oxidase (1.10.3.1), i.e. tyrosinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2023553453A 2021-03-03 2021-03-03 ヒドロキシチロソールの製造方法 Active JP7757412B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2021/055378 WO2022184255A1 (de) 2021-03-03 2021-03-03 Verfahren zur herstellung von hydroxytyrosol

Publications (3)

Publication Number Publication Date
JP2024509162A JP2024509162A (ja) 2024-02-29
JP2024509162A5 JP2024509162A5 (https=) 2025-04-01
JP7757412B2 true JP7757412B2 (ja) 2025-10-21

Family

ID=74870796

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023553453A Active JP7757412B2 (ja) 2021-03-03 2021-03-03 ヒドロキシチロソールの製造方法

Country Status (6)

Country Link
US (1) US20240200107A1 (https=)
EP (1) EP4301864A1 (https=)
JP (1) JP7757412B2 (https=)
KR (1) KR102889223B1 (https=)
CN (1) CN116964211A (https=)
WO (1) WO2022184255A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12564564B2 (en) 2024-07-22 2026-03-03 MolTek Nutrition Co., Ltd Composition comprising tyrosol and amino acids and its application in enhancing athletic performance and combating fatigue

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008064839A2 (en) 2006-11-27 2008-06-05 Dsm Ip Assets B.V. Method for preparing hydroxytyrosol
CN101624607A (zh) 2009-08-03 2010-01-13 山东省巨野晨农天然产物有限公司 一种羟基酪醇的制备方法
WO2016096579A1 (en) 2014-12-17 2016-06-23 University College Dublin, National University Of Ireland, Dublin A method for the enzymatic conversion of a phenol substrate into a corresponding catechol product

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2170006B1 (es) * 2000-08-11 2003-11-01 Consejo Superior Investigacion Sintesis enzimatica del antioxidante hidroxitirosol.
TNSN03042A1 (fr) 2003-07-23 2005-04-08 Ct De Biotechnologie De Sfax Cbs Procede d'extraction en continu et de purification de l'hydroxytyrosol.
ITMI20070519A1 (it) * 2007-03-15 2008-09-16 Maurizio Barontini Procedimento per la preparazione di derivati dell'idrossitirosolo e di idrossitirosolo
JP2010255647A (ja) * 2009-04-21 2010-11-11 Ntn Corp クロスグルーブ型等速自在継手
DE102011003387A1 (de) 2011-01-31 2012-08-02 Wacker Chemie Ag Verfahren zur fermentativen Herstellung von 2,3-Butandiol
DE102013203753A1 (de) 2013-03-05 2014-09-11 Wacker Chemie Ag Verfahren zur Herstellung von Hydroxytyrosol

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008064839A2 (en) 2006-11-27 2008-06-05 Dsm Ip Assets B.V. Method for preparing hydroxytyrosol
CN101624607A (zh) 2009-08-03 2010-01-13 山东省巨野晨农天然产物有限公司 一种羟基酪醇的制备方法
WO2016096579A1 (en) 2014-12-17 2016-06-23 University College Dublin, National University Of Ireland, Dublin A method for the enzymatic conversion of a phenol substrate into a corresponding catechol product

Also Published As

Publication number Publication date
US20240200107A1 (en) 2024-06-20
JP2024509162A (ja) 2024-02-29
KR102889223B1 (ko) 2025-11-20
WO2022184255A1 (de) 2022-09-09
KR20230150337A (ko) 2023-10-30
EP4301864A1 (de) 2024-01-10
CN116964211A (zh) 2023-10-27

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