CN116964211A - 用于生产羟基酪醇的方法 - Google Patents

用于生产羟基酪醇的方法 Download PDF

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Publication number
CN116964211A
CN116964211A CN202180095133.XA CN202180095133A CN116964211A CN 116964211 A CN116964211 A CN 116964211A CN 202180095133 A CN202180095133 A CN 202180095133A CN 116964211 A CN116964211 A CN 116964211A
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CN
China
Prior art keywords
hts
tyrosol
oxidase
ala
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180095133.XA
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English (en)
Chinese (zh)
Inventor
鲁珀特·普法勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wacker Chemie AG
Original Assignee
Wacker Chemie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wacker Chemie AG filed Critical Wacker Chemie AG
Publication of CN116964211A publication Critical patent/CN116964211A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0055—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10)
    • C12N9/0057—Oxidoreductases (1.) acting on diphenols and related substances as donors (1.10) with oxygen as acceptor (1.10.3)
    • C12N9/0059—Catechol oxidase (1.10.3.1), i.e. tyrosinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y110/00—Oxidoreductases acting on diphenols and related substances as donors (1.10)
    • C12Y110/03—Oxidoreductases acting on diphenols and related substances as donors (1.10) with an oxygen as acceptor (1.10.3)
    • C12Y110/03001—Catechol oxidase (1.10.3.1), i.e. tyrosinase

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202180095133.XA 2021-03-03 2021-03-03 用于生产羟基酪醇的方法 Pending CN116964211A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2021/055378 WO2022184255A1 (de) 2021-03-03 2021-03-03 Verfahren zur herstellung von hydroxytyrosol

Publications (1)

Publication Number Publication Date
CN116964211A true CN116964211A (zh) 2023-10-27

Family

ID=74870796

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180095133.XA Pending CN116964211A (zh) 2021-03-03 2021-03-03 用于生产羟基酪醇的方法

Country Status (6)

Country Link
US (1) US20240200107A1 (https=)
EP (1) EP4301864A1 (https=)
JP (1) JP7757412B2 (https=)
KR (1) KR102889223B1 (https=)
CN (1) CN116964211A (https=)
WO (1) WO2022184255A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12564564B2 (en) 2024-07-22 2026-03-03 MolTek Nutrition Co., Ltd Composition comprising tyrosol and amino acids and its application in enhancing athletic performance and combating fatigue

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2170006B1 (es) * 2000-08-11 2003-11-01 Consejo Superior Investigacion Sintesis enzimatica del antioxidante hidroxitirosol.
TNSN03042A1 (fr) 2003-07-23 2005-04-08 Ct De Biotechnologie De Sfax Cbs Procede d'extraction en continu et de purification de l'hydroxytyrosol.
WO2008064837A2 (en) * 2006-11-27 2008-06-05 Dsm Ip Assets B.V. Novel genes for the fermentative production of hydroxytyrosol
ITMI20070519A1 (it) * 2007-03-15 2008-09-16 Maurizio Barontini Procedimento per la preparazione di derivati dell'idrossitirosolo e di idrossitirosolo
JP2010255647A (ja) * 2009-04-21 2010-11-11 Ntn Corp クロスグルーブ型等速自在継手
CN101624607B (zh) * 2009-08-03 2012-09-19 山东省巨野晨农天然产物有限公司 一种羟基酪醇的制备方法
DE102011003387A1 (de) 2011-01-31 2012-08-02 Wacker Chemie Ag Verfahren zur fermentativen Herstellung von 2,3-Butandiol
DE102013203753A1 (de) 2013-03-05 2014-09-11 Wacker Chemie Ag Verfahren zur Herstellung von Hydroxytyrosol
PT3234164T (pt) * 2014-12-17 2019-05-30 Univ College Dublin Nat Univ Ireland Dublin Método para a conversão enzimática de um substrato fenólico num correspondente produto catecol

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12564564B2 (en) 2024-07-22 2026-03-03 MolTek Nutrition Co., Ltd Composition comprising tyrosol and amino acids and its application in enhancing athletic performance and combating fatigue

Also Published As

Publication number Publication date
US20240200107A1 (en) 2024-06-20
JP2024509162A (ja) 2024-02-29
KR102889223B1 (ko) 2025-11-20
WO2022184255A1 (de) 2022-09-09
JP7757412B2 (ja) 2025-10-21
KR20230150337A (ko) 2023-10-30
EP4301864A1 (de) 2024-01-10

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