KR102793118B1 - 카르보프로스트 및 이의 트로메타민 염의 제조 방법 - Google Patents

카르보프로스트 및 이의 트로메타민 염의 제조 방법 Download PDF

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Publication number
KR102793118B1
KR102793118B1 KR1020187018423A KR20187018423A KR102793118B1 KR 102793118 B1 KR102793118 B1 KR 102793118B1 KR 1020187018423 A KR1020187018423 A KR 1020187018423A KR 20187018423 A KR20187018423 A KR 20187018423A KR 102793118 B1 KR102793118 B1 KR 102793118B1
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South Korea
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chemical formula
carboprost
epimer
applying
silica gel
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Korean (ko)
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KR20180101353A (ko
Inventor
페테르 부즈데르-을런토시
주전너 커르도시
이렌 호르토바지
이슈트반 라슬로피
임레 유하스
라슬로 포너지
처버 바러디
아그네시 너지네 보르코
Original Assignee
키노인 기요기스제르 에스 베기에스제티 테르메크에크 기야라 제트알티.
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Application filed by 키노인 기요기스제르 에스 베기에스제티 테르메크에크 기야라 제트알티. filed Critical 키노인 기요기스제르 에스 베기에스제티 테르메크에크 기야라 제트알티.
Publication of KR20180101353A publication Critical patent/KR20180101353A/ko
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Publication of KR102793118B1 publication Critical patent/KR102793118B1/ko
Assigned to 유로에이피아이 헝가리 리미티드 라이어빌리티 캄파니 reassignment 유로에이피아이 헝가리 리미티드 라이어빌리티 캄파니 권리의 전부이전등록 Assignors: 키노인 기요기스제르 에스 베기에스제티 테르메크에크 기야라 제트알티.
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/265—Adsorption chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C07C7/12—Purification; Separation; Use of additives by adsorption, i.e. purification or separation of hydrocarbons with the aid of solids, e.g. with ion-exchangers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Water Supply & Treatment (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020187018423A 2015-12-01 2016-11-10 카르보프로스트 및 이의 트로메타민 염의 제조 방법 Active KR102793118B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU1500584A HU231045B1 (hu) 2015-12-01 2015-12-01 Új eljárás Carboprost trometamin elõállítására
HUP1500584 2015-12-01
PCT/HU2016/000067 WO2017093770A1 (en) 2015-12-01 2016-11-10 Process for the preparation of carboprost and its tromethamine salt

Publications (2)

Publication Number Publication Date
KR20180101353A KR20180101353A (ko) 2018-09-12
KR102793118B1 true KR102793118B1 (ko) 2025-04-07

Family

ID=89992009

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187018423A Active KR102793118B1 (ko) 2015-12-01 2016-11-10 카르보프로스트 및 이의 트로메타민 염의 제조 방법

Country Status (10)

Country Link
US (1) US10442762B2 (enExample)
EP (1) EP3383844B8 (enExample)
JP (1) JP6862448B2 (enExample)
KR (1) KR102793118B1 (enExample)
CN (1) CN108602769B (enExample)
ES (1) ES2812770T3 (enExample)
HU (2) HU231045B1 (enExample)
RU (1) RU2729626C2 (enExample)
TW (1) TWI738687B (enExample)
WO (1) WO2017093770A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110117242B (zh) * 2018-02-06 2021-06-22 广州楷模生物科技有限公司 卡前列素、氨丁三醇卡前列素的合成方法
KR102200892B1 (ko) * 2019-05-13 2021-01-12 대원제약주식회사 펠루비프로펜의 신규 염, 이의 제조방법 및 이를 포함하는 약학적 조성물
CN110746333B (zh) * 2019-10-31 2021-06-04 武汉嘉诺康医药技术有限公司 一种分离卡前列素异构体的方法
CN114262288B (zh) * 2020-09-16 2023-07-07 凯特立斯（深圳）科技有限公司 一类前列腺素类化合物合成关键中间体及其制备方法
CN112645861A (zh) * 2020-12-21 2021-04-13 上海彩迩文生化科技有限公司 一种分离卡前列素15位异构体的方法
US12565468B2 (en) 2021-08-23 2026-03-03 Chirogate International Inc. Processes and intermediates for the preparations of Carboprost and Carboprost Tromethamine, and Carboprost Tromethamine prepared therefrom
TWI805504B (zh) * 2021-08-23 2023-06-11 佳和桂科技股份有限公司 卡前列素緩血酸胺之結晶形式及其製備方法
CN113548993B (zh) * 2021-09-01 2022-05-27 河北化工医药职业技术学院 一种卡前列素的制备方法
CN114573489B (zh) * 2022-03-10 2023-08-22 河北化工医药职业技术学院 一种卡前列素的分离方法
CN115010692A (zh) * 2022-05-21 2022-09-06 上海彩迩文生化科技有限公司 一类新颖大环内酯的设计、制备及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008081191A1 (en) 2007-01-05 2008-07-10 Astrazeneca Pharma India Limited Improved method for the wittig reaction in the preparation of carboprost
US20130190404A1 (en) 2010-07-21 2013-07-25 Shanghai Techwell Biopharmaceutical Co., Ltd. Crystals of carboprost tromethamine and the preparation method as well as the uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3728382A (en) * 1970-05-04 1973-04-17 Upjohn Co 15-methyl and 15-ethyl prostaglandin analogs
IN185790B (enExample) 1997-05-13 2001-04-28 Council Scient Ind Res
WO2011008756A1 (en) 2009-07-13 2011-01-20 Irix Pharmaceuticals Synthesis of prostanoids
CN102816099A (zh) * 2011-06-09 2012-12-12 上海天伟生物制药有限公司 一种高纯度的卡前列素氨丁三醇及其制备方法和用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008081191A1 (en) 2007-01-05 2008-07-10 Astrazeneca Pharma India Limited Improved method for the wittig reaction in the preparation of carboprost
US20130190404A1 (en) 2010-07-21 2013-07-25 Shanghai Techwell Biopharmaceutical Co., Ltd. Crystals of carboprost tromethamine and the preparation method as well as the uses thereof

Also Published As

Publication number Publication date
ES2812770T3 (es) 2021-03-18
HU231045B1 (hu) 2020-01-28
TWI738687B (zh) 2021-09-11
RU2729626C2 (ru) 2020-08-11
JP2019502666A (ja) 2019-01-31
CN108602769A (zh) 2018-09-28
RU2018123738A3 (enExample) 2020-02-17
TW201733980A (zh) 2017-10-01
KR20180101353A (ko) 2018-09-12
EP3383844B1 (en) 2020-06-03
HUE050782T2 (hu) 2021-01-28
CN108602769B (zh) 2020-11-13
EP3383844A1 (en) 2018-10-10
US10442762B2 (en) 2019-10-15
HUP1500584A2 (en) 2017-06-28
RU2018123738A (ru) 2020-01-09
US20180362457A1 (en) 2018-12-20
WO2017093770A1 (en) 2017-06-08
EP3383844B8 (en) 2020-08-19
JP6862448B2 (ja) 2021-04-21

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