KR102764124B1 - 혈액 장애의 치료에 사용하기 위한 피루브산 키나아제 활성화제 - Google Patents

혈액 장애의 치료에 사용하기 위한 피루브산 키나아제 활성화제 Download PDF

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KR102764124B1
KR102764124B1 KR1020237028222A KR20237028222A KR102764124B1 KR 102764124 B1 KR102764124 B1 KR 102764124B1 KR 1020237028222 A KR1020237028222 A KR 1020237028222A KR 20237028222 A KR20237028222 A KR 20237028222A KR 102764124 B1 KR102764124 B1 KR 102764124B1
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methyl
pharmaceutically acceptable
acceptable salt
compound
pyrrolo
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KR20230127364A (ko
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지오반니 시안체타
타오 리우
아닐 쿠마 파다이아나
지후아 수이
첸웨이 카이
다웨이 쿠이
징징 지
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아지오스 파마슈티컬스 아이엔씨.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020237028222A 2017-08-15 2018-08-15 혈액 장애의 치료에 사용하기 위한 피루브산 키나아제 활성화제 Active KR102764124B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
CN2017097496 2017-08-15
CNPCT/CN2017/097496 2017-08-15
US201862673533P 2018-05-18 2018-05-18
US201862673526P 2018-05-18 2018-05-18
US62/673,526 2018-05-18
US62/673,533 2018-05-18
PCT/US2018/000128 WO2019035864A1 (en) 2017-08-15 2018-08-15 PYRUVATE KINASE ACTIVATORS FOR USE IN THE TREATMENT OF BLOOD DISORDERS
KR1020207007344A KR102717594B1 (ko) 2017-08-15 2018-08-15 혈액 장애의 치료에 사용하기 위한 피루브산 키나아제 활성화제

Related Parent Applications (1)

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KR1020207007344A Division KR102717594B1 (ko) 2017-08-15 2018-08-15 혈액 장애의 치료에 사용하기 위한 피루브산 키나아제 활성화제

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KR20230127364A KR20230127364A (ko) 2023-08-31
KR102764124B1 true KR102764124B1 (ko) 2025-02-05

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KR1020207007344A Active KR102717594B1 (ko) 2017-08-15 2018-08-15 혈액 장애의 치료에 사용하기 위한 피루브산 키나아제 활성화제
KR1020207007346A Active KR102642408B1 (ko) 2017-08-15 2018-08-15 피루브산 키나아제 조절제 및 이의 용도

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KR1020207007346A Active KR102642408B1 (ko) 2017-08-15 2018-08-15 피루브산 키나아제 조절제 및 이의 용도

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WO2022020424A1 (en) * 2020-07-21 2022-01-27 The Regents Of The University Of Michigan Compositions and methods for activating pyruvate kinase
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DK3668513T3 (da) 2022-01-10
CA3072455A1 (en) 2019-02-21
PL3668512T3 (pl) 2023-06-19
US20210130371A1 (en) 2021-05-06
HUE061910T2 (hu) 2023-08-28
PT3668512T (pt) 2023-05-22
MX2020001832A (es) 2020-07-22
EP3668881A1 (en) 2020-06-24
CN111032046A (zh) 2020-04-17
US11872225B2 (en) 2024-01-16
TW201919631A (zh) 2019-06-01
CN117186119A (zh) 2023-12-08
SG11202001353PA (en) 2020-03-30
AU2018316587A1 (en) 2020-02-20
IL272599A (en) 2020-03-31
CN111032045A (zh) 2020-04-17
TW202323258A (zh) 2023-06-16
JP2023027276A (ja) 2023-03-01
CN111032046B (zh) 2023-09-26
BR112020003254A2 (pt) 2020-10-27
AU2018316587B2 (en) 2023-05-11
LT3668513T (lt) 2022-03-25
JP2024147805A (ja) 2024-10-16
KR20230127364A (ko) 2023-08-31
ES2905100T3 (es) 2022-04-07
JP2020531432A (ja) 2020-11-05
IL272599B (en) 2022-08-01
HUE057178T2 (hu) 2022-04-28
US20200206225A1 (en) 2020-07-02
IL292530B2 (en) 2023-06-01
DK3668512T3 (da) 2023-05-22
HRP20220039T1 (hr) 2022-04-15
IL272597B (en) 2022-06-01
SMT202300146T1 (it) 2023-07-20
AU2018316588B2 (en) 2023-02-02
AU2018316588A1 (en) 2020-02-20
AU2023202772A1 (en) 2023-05-18
CN111032045B (zh) 2023-08-15
US11590132B2 (en) 2023-02-28
CO2020002961A2 (es) 2020-04-13
RU2020110573A (ru) 2021-09-16
BR112020003262A2 (pt) 2020-09-01
JP7301040B2 (ja) 2023-06-30
KR102642408B1 (ko) 2024-02-28
US20230226055A1 (en) 2023-07-20
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