KR102755284B1 - 골 표적화 항체 - Google Patents

골 표적화 항체 Download PDF

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Publication number
KR102755284B1
KR102755284B1 KR1020237042558A KR20237042558A KR102755284B1 KR 102755284 B1 KR102755284 B1 KR 102755284B1 KR 1020237042558 A KR1020237042558 A KR 1020237042558A KR 20237042558 A KR20237042558 A KR 20237042558A KR 102755284 B1 KR102755284 B1 KR 102755284B1
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South Korea
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leu
mab1
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Korean (ko)
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KR20230172039A (ko
Inventor
화웨이 추
성해 박
제임스 스테파노
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젠자임 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020237042558A 2017-01-20 2018-01-19 골 표적화 항체 Active KR102755284B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257000987A KR20250012197A (ko) 2017-01-20 2018-01-19 골 표적화 항체

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762448763P 2017-01-20 2017-01-20
US62/448,763 2017-01-20
PCT/US2018/014350 WO2018136698A2 (en) 2017-01-20 2018-01-19 Bone-targeting antibodies
KR1020197024021A KR102613463B1 (ko) 2017-01-20 2018-01-19 골 표적화 항체

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197024021A Division KR102613463B1 (ko) 2017-01-20 2018-01-19 골 표적화 항체

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257000987A Division KR20250012197A (ko) 2017-01-20 2018-01-19 골 표적화 항체

Publications (2)

Publication Number Publication Date
KR20230172039A KR20230172039A (ko) 2023-12-21
KR102755284B1 true KR102755284B1 (ko) 2025-01-22

Family

ID=61581744

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020237042558A Active KR102755284B1 (ko) 2017-01-20 2018-01-19 골 표적화 항체
KR1020197024021A Active KR102613463B1 (ko) 2017-01-20 2018-01-19 골 표적화 항체
KR1020257000987A Pending KR20250012197A (ko) 2017-01-20 2018-01-19 골 표적화 항체

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020197024021A Active KR102613463B1 (ko) 2017-01-20 2018-01-19 골 표적화 항체
KR1020257000987A Pending KR20250012197A (ko) 2017-01-20 2018-01-19 골 표적화 항체

Country Status (17)

Country Link
US (3) US10844115B2 (https=)
EP (1) EP3571226A2 (https=)
JP (3) JP7227138B2 (https=)
KR (3) KR102755284B1 (https=)
CN (2) CN111032690B (https=)
AR (1) AR110755A1 (https=)
AU (1) AU2018210270A1 (https=)
BR (1) BR112019013986A2 (https=)
CA (1) CA3050884A1 (https=)
IL (2) IL268114B2 (https=)
MX (2) MX2019008549A (https=)
MY (2) MY194819A (https=)
SG (1) SG11201906663VA (https=)
TW (3) TWI788321B (https=)
UY (1) UY37576A (https=)
WO (1) WO2018136698A2 (https=)
ZA (1) ZA201907673B (https=)

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Publication number Publication date
TW202421659A (zh) 2024-06-01
KR20190105236A (ko) 2019-09-16
JP7227138B2 (ja) 2023-02-21
WO2018136698A3 (en) 2018-08-30
IL268114A (en) 2019-09-26
KR20250012197A (ko) 2025-01-23
US20210163584A1 (en) 2021-06-03
UY37576A (es) 2018-10-31
US10844115B2 (en) 2020-11-24
US20180208650A1 (en) 2018-07-26
KR102613463B1 (ko) 2023-12-15
TW201839013A (zh) 2018-11-01
IL317592A (en) 2025-02-01
TWI832600B (zh) 2024-02-11
RU2019126026A (ru) 2021-02-20
BR112019013986A2 (pt) 2020-03-03
JP2025028981A (ja) 2025-03-05
WO2018136698A2 (en) 2018-07-26
TW202330597A (zh) 2023-08-01
US12098194B2 (en) 2024-09-24
SG11201906663VA (en) 2019-08-27
JP2023058590A (ja) 2023-04-25
ZA201907673B (en) 2021-05-26
KR20230172039A (ko) 2023-12-21
RU2019126026A3 (https=) 2021-11-09
CN118121696A (zh) 2024-06-04
CN111032690B (zh) 2024-03-26
EP3571226A2 (en) 2019-11-27
AU2018210270A1 (en) 2019-09-05
TWI788321B (zh) 2023-01-01
JP2020505919A (ja) 2020-02-27
MX2019008549A (es) 2019-09-11
MY194819A (en) 2022-12-17
JP7597836B2 (ja) 2024-12-10
MY207919A (en) 2025-03-27
CA3050884A1 (en) 2018-07-26
AR110755A1 (es) 2019-05-02
CN111032690A (zh) 2020-04-17
IL268114B1 (en) 2025-01-01
US20250074975A1 (en) 2025-03-06
IL268114B2 (en) 2025-05-01
MX2022008073A (es) 2022-07-27

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