KR102658724B1 - Ccr3-저해제를 사용하여 망막-관련 질병을 치료하는 방법 및 조성물 - Google Patents

Ccr3-저해제를 사용하여 망막-관련 질병을 치료하는 방법 및 조성물 Download PDF

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KR102658724B1
KR102658724B1 KR1020197032819A KR20197032819A KR102658724B1 KR 102658724 B1 KR102658724 B1 KR 102658724B1 KR 1020197032819 A KR1020197032819 A KR 1020197032819A KR 20197032819 A KR20197032819 A KR 20197032819A KR 102658724 B1 KR102658724 B1 KR 102658724B1
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로라 코라디니
샘 잭슨
카롤리 니콜리치
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알카헤스트 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
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KR1020197032819A 2017-04-05 2018-04-04 Ccr3-저해제를 사용하여 망막-관련 질병을 치료하는 방법 및 조성물 Active KR102658724B1 (ko)

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US201762482134P 2017-04-05 2017-04-05
US62/482,134 2017-04-05
PCT/US2018/026091 WO2018187473A1 (en) 2017-04-05 2018-04-04 Methods and compositions for treating retina-associated disease using ccr3-inhibitors

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KR20190131121A KR20190131121A (ko) 2019-11-25
KR102658724B1 true KR102658724B1 (ko) 2024-04-18

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US (2) US11590118B2 (https=)
EP (2) EP3606521B1 (https=)
JP (1) JP7179755B2 (https=)
KR (1) KR102658724B1 (https=)
CN (1) CN110650740A (https=)
AU (2) AU2018248425B2 (https=)
BR (1) BR112019020430A2 (https=)
CA (1) CA3058654A1 (https=)
CL (1) CL2019002839A1 (https=)
CO (1) CO2019012336A2 (https=)
EA (1) EA201992356A1 (https=)
ES (2) ES2950453T3 (https=)
IL (1) IL269743B (https=)
MX (1) MX394915B (https=)
MY (1) MY199462A (https=)
NZ (1) NZ757769A (https=)
SG (1) SG11201909207VA (https=)
TW (1) TW201841636A (https=)
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Publication number Priority date Publication date Assignee Title
SG11201909245PA (en) * 2017-04-05 2019-11-28 Alkahest Inc Methods and compositions for treating aging-associated impairments using ccr3-inhibitors
CN112789044A (zh) * 2018-09-26 2021-05-11 万能溶剂有限公司 使用ccr3-抑制剂治疗衰老相关损伤的方法及组合物
AU2021287906B2 (en) * 2020-06-11 2025-09-11 Alkahest Inc. Methods of improving retina-associated disease outcome using CCR3-inhibitors
CN112322719A (zh) * 2020-11-06 2021-02-05 温州医科大学 循环血外泌体miRNA作为视网膜静脉阻塞疾病诊断标志物中的应用

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* Cited by examiner, † Cited by third party
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RU2002112800A (ru) 2002-05-16 2004-03-10 Евгений Ильич Зарайский (RU) Способ лечения диабетической ретинопатии
US8008092B2 (en) 2007-10-09 2011-08-30 University Of Kentucky Research Foundation CCR3 inhibition for ocular angiogenesis and macular degeneration
US8278302B2 (en) * 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
UA109290C2 (uk) 2010-10-07 2015-08-10 Спільні кристали і солі інгібіторів ccr3
RU2014126070A (ru) 2011-12-01 2016-01-27 Глэксо Груп Лимитед Способы лечения и предотвращения глазных заболеваний
AR090566A1 (es) 2012-04-02 2014-11-19 Boehringer Ingelheim Int Proceso para la produccion de inhibidores de crr
US20130261153A1 (en) * 2012-04-03 2013-10-03 Boehringer Ingelheim International Gmbh Use of ccr3-inhibitors
US10213421B2 (en) * 2012-04-04 2019-02-26 Alkahest, Inc. Pharmaceutical formulations comprising CCR3 antagonists
SG11201909245PA (en) 2017-04-05 2019-11-28 Alkahest Inc Methods and compositions for treating aging-associated impairments using ccr3-inhibitors

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Publication number Publication date
US11951102B2 (en) 2024-04-09
EP4245295A3 (en) 2023-11-01
MY199462A (en) 2023-10-30
ES3046717T3 (en) 2025-12-02
IL269743A (en) 2019-11-28
TW201841636A (zh) 2018-12-01
JP2020513004A (ja) 2020-04-30
US20240024305A1 (en) 2024-01-25
EP3606521B1 (en) 2023-04-19
EP4245295A2 (en) 2023-09-20
NZ757769A (en) 2025-10-31
JP7179755B2 (ja) 2022-11-29
KR20190131121A (ko) 2019-11-25
MX394915B (es) 2025-03-24
BR112019020430A2 (pt) 2021-03-30
EA201992356A1 (ru) 2020-03-23
CO2019012336A2 (es) 2020-04-01
US20210106577A1 (en) 2021-04-15
CN110650740A (zh) 2020-01-03
MX2019012012A (es) 2019-12-11
UA125658C2 (uk) 2022-05-11
IL269743B (en) 2022-09-01
US11590118B2 (en) 2023-02-28
AU2024204133B2 (en) 2026-03-26
ES2950453T3 (es) 2023-10-10
EP3606521A1 (en) 2020-02-12
AU2024204133A1 (en) 2024-07-04
CL2019002839A1 (es) 2020-06-05
WO2018187473A1 (en) 2018-10-11
SG11201909207VA (en) 2019-11-28
CA3058654A1 (en) 2018-10-11
AU2018248425A1 (en) 2019-10-31
EP4245295B1 (en) 2025-08-06
AU2018248425B2 (en) 2024-03-28

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