MX2019012012A - Metodos y composiciones para tratar enfermedades asociadas a la retina mediante inhibidores de ccr3. - Google Patents

Metodos y composiciones para tratar enfermedades asociadas a la retina mediante inhibidores de ccr3.

Info

Publication number
MX2019012012A
MX2019012012A MX2019012012A MX2019012012A MX2019012012A MX 2019012012 A MX2019012012 A MX 2019012012A MX 2019012012 A MX2019012012 A MX 2019012012A MX 2019012012 A MX2019012012 A MX 2019012012A MX 2019012012 A MX2019012012 A MX 2019012012A
Authority
MX
Mexico
Prior art keywords
methods
ccr3
associated disease
retina
inhibitors
Prior art date
Application number
MX2019012012A
Other languages
English (en)
Inventor
Nikolich Karoly
CORADINI Laura
Jackson Sam
Original Assignee
Alkahest Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkahest Inc filed Critical Alkahest Inc
Publication of MX2019012012A publication Critical patent/MX2019012012A/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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    • A61K9/20—Pills, tablets, discs, rods
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/20—Pills, tablets, discs, rods
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    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Se proporcionan métodos para mejorar los criterios de valoración visuales relacionados con las enfermedades asociadas a la retina con agentes moduladores de CCR3. Un ejemplo de tal criterio de valoración es la agudeza visual. Las enfermedades asociadas a la retina al respecto de las cuales se puede mejorar la agudeza visual y otros criterios de valoración visuales incluyen retinopatía del prematuro, degeneración macular relacionada con la edad, oclusión de la vena central de la retina y retinopatía diabética.
MX2019012012A 2017-04-05 2018-04-04 Metodos y composiciones para tratar enfermedades asociadas a la retina mediante inhibidores de ccr3. MX2019012012A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762482134P 2017-04-05 2017-04-05
PCT/US2018/026091 WO2018187473A1 (en) 2017-04-05 2018-04-04 Methods and compositions for treating retina-associated disease using ccr3-inhibitors

Publications (1)

Publication Number Publication Date
MX2019012012A true MX2019012012A (es) 2019-12-11

Family

ID=62067800

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019012012A MX2019012012A (es) 2017-04-05 2018-04-04 Metodos y composiciones para tratar enfermedades asociadas a la retina mediante inhibidores de ccr3.

Country Status (18)

Country Link
US (2) US11590118B2 (es)
EP (2) EP3606521B1 (es)
JP (1) JP7179755B2 (es)
KR (1) KR102658724B1 (es)
CN (1) CN110650740A (es)
AU (1) AU2018248425B2 (es)
BR (1) BR112019020430A2 (es)
CA (1) CA3058654A1 (es)
CL (1) CL2019002839A1 (es)
CO (1) CO2019012336A2 (es)
EA (1) EA201992356A1 (es)
ES (1) ES2950453T3 (es)
IL (1) IL269743B (es)
MX (1) MX2019012012A (es)
SG (1) SG11201909207VA (es)
TW (1) TW201841636A (es)
UA (1) UA125658C2 (es)
WO (1) WO2018187473A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201909245PA (en) 2017-04-05 2019-11-28 Alkahest Inc Methods and compositions for treating aging-associated impairments using ccr3-inhibitors
CA3111433A1 (en) * 2018-09-26 2020-04-02 Alkahest, Inc. Methods and compositions for treating aging-associated impairments using ccr3-inhibitors
WO2021252647A1 (en) * 2020-06-11 2021-12-16 Alkahest Inc. Methods of improving retina-associated disease outcome using ccr3-inhibitors
CN112322719A (zh) * 2020-11-06 2021-02-05 温州医科大学 循环血外泌体miRNA作为视网膜静脉阻塞疾病诊断标志物中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2002112800A (ru) 2002-05-16 2004-03-10 Евгений Ильич Зарайский (RU) Способ лечения диабетической ретинопатии
US8008092B2 (en) 2007-10-09 2011-08-30 University Of Kentucky Research Foundation CCR3 inhibition for ocular angiogenesis and macular degeneration
US8278302B2 (en) 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
UA109290C2 (uk) 2010-10-07 2015-08-10 Спільні кристали і солі інгібіторів ccr3
CN104203231A (zh) * 2011-12-01 2014-12-10 葛兰素集团有限公司 治疗和预防眼疾病的方法
US8680280B2 (en) 2012-04-02 2014-03-25 Boehringer Ingelheim International Gmbh Process for the manufacturing of CRR inhibitors
US20130261153A1 (en) * 2012-04-03 2013-10-03 Boehringer Ingelheim International Gmbh Use of ccr3-inhibitors
US10213421B2 (en) * 2012-04-04 2019-02-26 Alkahest, Inc. Pharmaceutical formulations comprising CCR3 antagonists
SG11201909245PA (en) 2017-04-05 2019-11-28 Alkahest Inc Methods and compositions for treating aging-associated impairments using ccr3-inhibitors

Also Published As

Publication number Publication date
AU2018248425B2 (en) 2024-03-28
ES2950453T3 (es) 2023-10-10
EP3606521A1 (en) 2020-02-12
EP4245295A2 (en) 2023-09-20
IL269743B (en) 2022-09-01
US20240024305A1 (en) 2024-01-25
US20210106577A1 (en) 2021-04-15
CN110650740A (zh) 2020-01-03
UA125658C2 (uk) 2022-05-11
CO2019012336A2 (es) 2020-04-01
WO2018187473A1 (en) 2018-10-11
JP2020513004A (ja) 2020-04-30
US11951102B2 (en) 2024-04-09
TW201841636A (zh) 2018-12-01
EA201992356A1 (ru) 2020-03-23
CL2019002839A1 (es) 2020-06-05
US11590118B2 (en) 2023-02-28
KR20190131121A (ko) 2019-11-25
BR112019020430A2 (pt) 2021-03-30
CA3058654A1 (en) 2018-10-11
SG11201909207VA (en) 2019-11-28
EP3606521B1 (en) 2023-04-19
EP4245295A3 (en) 2023-11-01
KR102658724B1 (ko) 2024-04-18
AU2018248425A1 (en) 2019-10-31
IL269743A (en) 2019-11-28
JP7179755B2 (ja) 2022-11-29

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