KR102656571B1 - 아르기나아제 억제제 - Google Patents

아르기나아제 억제제 Download PDF

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KR102656571B1
KR102656571B1 KR1020207028200A KR20207028200A KR102656571B1 KR 102656571 B1 KR102656571 B1 KR 102656571B1 KR 1020207028200 A KR1020207028200 A KR 1020207028200A KR 20207028200 A KR20207028200 A KR 20207028200A KR 102656571 B1 KR102656571 B1 KR 102656571B1
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cancer
group
disease
arginase
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KR20200128117A (ko
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코린 니콜 폴리
레베카 루이스 그랜지
테즈칸 구네이
야로스와프 칼리샥
에릭 토마스 뉴컴
안 투 트란
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아르커스 바이오사이언시즈 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020207028200A 2018-03-05 2019-03-04 아르기나아제 억제제 Active KR102656571B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862638412P 2018-03-05 2018-03-05
US62/638,412 2018-03-05
PCT/US2019/020507 WO2019173188A1 (en) 2018-03-05 2019-03-04 Arginase inhibitors

Publications (2)

Publication Number Publication Date
KR20200128117A KR20200128117A (ko) 2020-11-11
KR102656571B1 true KR102656571B1 (ko) 2024-04-11

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KR1020207028200A Active KR102656571B1 (ko) 2018-03-05 2019-03-04 아르기나아제 억제제

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EP (1) EP3761992A4 (enExample)
JP (1) JP7402167B2 (enExample)
KR (1) KR102656571B1 (enExample)
CN (1) CN111818928A (enExample)
AU (1) AU2019229978B2 (enExample)
BR (1) BR112020017604A2 (enExample)
CA (1) CA3091805A1 (enExample)
CL (1) CL2020002271A1 (enExample)
CO (1) CO2020012060A2 (enExample)
CR (1) CR20200445A (enExample)
EA (1) EA202092086A1 (enExample)
IL (1) IL276813B2 (enExample)
MX (1) MX2020009290A (enExample)
MY (1) MY205512A (enExample)
PE (1) PE20210452A1 (enExample)
PH (1) PH12020551352A1 (enExample)
SG (1) SG11202008113RA (enExample)
UA (1) UA127897C2 (enExample)
WO (1) WO2019173188A1 (enExample)
ZA (1) ZA202006006B (enExample)

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EP3810615B1 (en) * 2018-06-20 2026-01-28 Merck Sharp & Dohme LLC Arginase inhibitors and methods of use
EP3880685B1 (en) 2018-11-16 2025-06-18 Arcus Biosciences, Inc. Inhibitors of arg1 and/or arg2
EP3897622B1 (en) 2018-12-18 2026-01-14 Merck Sharp & Dohme LLC Arginase inhibitors and methods of use
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TW202325279A (zh) 2021-10-29 2023-07-01 美商阿克思生物科學有限公司 HIF-2α抑制劑及其使用方法
CN119156228A (zh) 2022-05-02 2024-12-17 艾库斯生物科学有限公司 抗tigit抗体及其用途
EP4554680A1 (en) 2022-07-15 2025-05-21 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
WO2024020034A1 (en) 2022-07-20 2024-01-25 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
TW202421150A (zh) 2022-09-14 2024-06-01 美商阿克思生物科學有限公司 艾魯美冷之分散體
EP4602041A1 (en) 2022-10-14 2025-08-20 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
CN120091809A (zh) 2022-10-20 2025-06-03 艾库斯生物科学有限公司 Cd73化合物的冻干制剂
EP4705292A1 (en) 2023-05-05 2026-03-11 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2024243502A1 (en) 2023-05-25 2024-11-28 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
EP4788432A1 (en) 2023-10-06 2026-08-12 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2025193759A1 (en) 2024-03-12 2025-09-18 Gilead Sciences, Inc. Solid forms of an azolopyrimidine compound

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IL276813B2 (en) 2024-09-01
ZA202006006B (en) 2025-02-26
UA127897C2 (uk) 2024-02-07
CO2020012060A2 (es) 2021-01-18
PE20210452A1 (es) 2021-03-08
CA3091805A1 (en) 2019-09-12
CL2020002271A1 (es) 2021-04-09
EP3761992A1 (en) 2021-01-13
JP2021516237A (ja) 2021-07-01
KR20200128117A (ko) 2020-11-11
AU2019229978A1 (en) 2020-10-15
MX2020009290A (es) 2020-09-28
CR20200445A (es) 2021-04-27
US12054500B2 (en) 2024-08-06
AU2019229978B2 (en) 2024-05-30
US20210002306A1 (en) 2021-01-07
MY205512A (en) 2024-10-24
CN111818928A (zh) 2020-10-23
WO2019173188A1 (en) 2019-09-12
JP7402167B2 (ja) 2023-12-20
IL276813A (en) 2020-10-29
EA202092086A1 (ru) 2021-02-09
SG11202008113RA (en) 2020-09-29
BR112020017604A2 (pt) 2020-12-22
IL276813B1 (en) 2024-05-01
PH12020551352A1 (en) 2021-06-21
EP3761992A4 (en) 2021-11-24

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