JP7402167B2 - アルギナーゼ阻害剤 - Google Patents

アルギナーゼ阻害剤 Download PDF

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Publication number
JP7402167B2
JP7402167B2 JP2020546139A JP2020546139A JP7402167B2 JP 7402167 B2 JP7402167 B2 JP 7402167B2 JP 2020546139 A JP2020546139 A JP 2020546139A JP 2020546139 A JP2020546139 A JP 2020546139A JP 7402167 B2 JP7402167 B2 JP 7402167B2
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cancer
group
pharmaceutical composition
arginase
acid
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Japanese (ja)
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JP2021516237A5 (enExample
JP2021516237A (ja
Inventor
ニコル フォーリー コリン
ルイーズ グレンジ レベッカ
ギュネイ テズキャン
カリシーク ヤロスワフ
トーマス ニューカム エリック
ツ トラン アン
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アーカス バイオサイエンシズ インコーポレイティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2020546139A 2018-03-05 2019-03-04 アルギナーゼ阻害剤 Active JP7402167B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862638412P 2018-03-05 2018-03-05
US62/638,412 2018-03-05
PCT/US2019/020507 WO2019173188A1 (en) 2018-03-05 2019-03-04 Arginase inhibitors

Publications (3)

Publication Number Publication Date
JP2021516237A JP2021516237A (ja) 2021-07-01
JP2021516237A5 JP2021516237A5 (enExample) 2022-03-14
JP7402167B2 true JP7402167B2 (ja) 2023-12-20

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ID=67847429

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020546139A Active JP7402167B2 (ja) 2018-03-05 2019-03-04 アルギナーゼ阻害剤

Country Status (21)

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US (1) US12054500B2 (enExample)
EP (1) EP3761992A4 (enExample)
JP (1) JP7402167B2 (enExample)
KR (1) KR102656571B1 (enExample)
CN (1) CN111818928A (enExample)
AU (1) AU2019229978B2 (enExample)
BR (1) BR112020017604A2 (enExample)
CA (1) CA3091805A1 (enExample)
CL (1) CL2020002271A1 (enExample)
CO (1) CO2020012060A2 (enExample)
CR (1) CR20200445A (enExample)
EA (1) EA202092086A1 (enExample)
IL (1) IL276813B2 (enExample)
MX (1) MX2020009290A (enExample)
MY (1) MY205512A (enExample)
PE (1) PE20210452A1 (enExample)
PH (1) PH12020551352A1 (enExample)
SG (1) SG11202008113RA (enExample)
UA (1) UA127897C2 (enExample)
WO (1) WO2019173188A1 (enExample)
ZA (1) ZA202006006B (enExample)

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EP3810615B1 (en) * 2018-06-20 2026-01-28 Merck Sharp & Dohme LLC Arginase inhibitors and methods of use
EP3880685B1 (en) 2018-11-16 2025-06-18 Arcus Biosciences, Inc. Inhibitors of arg1 and/or arg2
EP3897622B1 (en) 2018-12-18 2026-01-14 Merck Sharp & Dohme LLC Arginase inhibitors and methods of use
CA3179320A1 (en) 2020-06-17 2021-12-23 Arcus Biosciences, Inc. Crystalline forms of a cd73 inhibitor and uses thereof
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TW202325279A (zh) 2021-10-29 2023-07-01 美商阿克思生物科學有限公司 HIF-2α抑制劑及其使用方法
CN119156228A (zh) 2022-05-02 2024-12-17 艾库斯生物科学有限公司 抗tigit抗体及其用途
EP4554680A1 (en) 2022-07-15 2025-05-21 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
WO2024020034A1 (en) 2022-07-20 2024-01-25 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
TW202421150A (zh) 2022-09-14 2024-06-01 美商阿克思生物科學有限公司 艾魯美冷之分散體
EP4602041A1 (en) 2022-10-14 2025-08-20 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
CN120091809A (zh) 2022-10-20 2025-06-03 艾库斯生物科学有限公司 Cd73化合物的冻干制剂
EP4705292A1 (en) 2023-05-05 2026-03-11 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2024243502A1 (en) 2023-05-25 2024-11-28 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
EP4788432A1 (en) 2023-10-06 2026-08-12 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
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Also Published As

Publication number Publication date
IL276813B2 (en) 2024-09-01
ZA202006006B (en) 2025-02-26
UA127897C2 (uk) 2024-02-07
CO2020012060A2 (es) 2021-01-18
PE20210452A1 (es) 2021-03-08
CA3091805A1 (en) 2019-09-12
CL2020002271A1 (es) 2021-04-09
EP3761992A1 (en) 2021-01-13
JP2021516237A (ja) 2021-07-01
KR20200128117A (ko) 2020-11-11
AU2019229978A1 (en) 2020-10-15
MX2020009290A (es) 2020-09-28
CR20200445A (es) 2021-04-27
KR102656571B1 (ko) 2024-04-11
US12054500B2 (en) 2024-08-06
AU2019229978B2 (en) 2024-05-30
US20210002306A1 (en) 2021-01-07
MY205512A (en) 2024-10-24
CN111818928A (zh) 2020-10-23
WO2019173188A1 (en) 2019-09-12
IL276813A (en) 2020-10-29
EA202092086A1 (ru) 2021-02-09
SG11202008113RA (en) 2020-09-29
BR112020017604A2 (pt) 2020-12-22
IL276813B1 (en) 2024-05-01
PH12020551352A1 (en) 2021-06-21
EP3761992A4 (en) 2021-11-24

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