JP7402167B2 - アルギナーゼ阻害剤 - Google Patents

アルギナーゼ阻害剤 Download PDF

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JP7402167B2
JP7402167B2 JP2020546139A JP2020546139A JP7402167B2 JP 7402167 B2 JP7402167 B2 JP 7402167B2 JP 2020546139 A JP2020546139 A JP 2020546139A JP 2020546139 A JP2020546139 A JP 2020546139A JP 7402167 B2 JP7402167 B2 JP 7402167B2
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cancer
group
pharmaceutical composition
arginase
acid
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JP2021516237A5 (enExample
JP2021516237A (ja
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ニコル フォーリー コリン
ルイーズ グレンジ レベッカ
ギュネイ テズキャン
カリシーク ヤロスワフ
トーマス ニューカム エリック
ツ トラン アン
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アーカス バイオサイエンシズ インコーポレイティド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2020546139A 2018-03-05 2019-03-04 アルギナーゼ阻害剤 Active JP7402167B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862638412P 2018-03-05 2018-03-05
US62/638,412 2018-03-05
PCT/US2019/020507 WO2019173188A1 (en) 2018-03-05 2019-03-04 Arginase inhibitors

Publications (3)

Publication Number Publication Date
JP2021516237A JP2021516237A (ja) 2021-07-01
JP2021516237A5 JP2021516237A5 (enExample) 2022-03-14
JP7402167B2 true JP7402167B2 (ja) 2023-12-20

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JP2020546139A Active JP7402167B2 (ja) 2018-03-05 2019-03-04 アルギナーゼ阻害剤

Country Status (21)

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US (1) US12054500B2 (enExample)
EP (1) EP3761992A4 (enExample)
JP (1) JP7402167B2 (enExample)
KR (1) KR102656571B1 (enExample)
CN (1) CN111818928A (enExample)
AU (1) AU2019229978B2 (enExample)
BR (1) BR112020017604A2 (enExample)
CA (1) CA3091805A1 (enExample)
CL (1) CL2020002271A1 (enExample)
CO (1) CO2020012060A2 (enExample)
CR (1) CR20200445A (enExample)
EA (1) EA202092086A1 (enExample)
IL (1) IL276813B2 (enExample)
MX (1) MX2020009290A (enExample)
MY (1) MY205512A (enExample)
PE (1) PE20210452A1 (enExample)
PH (1) PH12020551352A1 (enExample)
SG (1) SG11202008113RA (enExample)
UA (1) UA127897C2 (enExample)
WO (1) WO2019173188A1 (enExample)
ZA (1) ZA202006006B (enExample)

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TWI828800B (zh) 2018-11-16 2024-01-11 美商阿克思生物科學有限公司 Arg1及/或arg2之抑制劑
EP3897622B1 (en) 2018-12-18 2026-01-14 Merck Sharp & Dohme LLC Arginase inhibitors and methods of use
KR20230026312A (ko) 2020-06-17 2023-02-24 아르커스 바이오사이언시즈 인코포레이티드 Cd73 억제제의 결정형 및 이의 용도
TW202228720A (zh) 2020-12-22 2022-08-01 波蘭商昂科艾倫迪治療法股份公司 精胺酸酶抑制劑及其使用方法
WO2023077046A1 (en) 2021-10-29 2023-05-04 Arcus Biosciences, Inc. Inhibitors of hif-2alpha and methods of use thereof
AU2023264591A1 (en) 2022-05-02 2024-11-07 Arcus Biosciences, Inc. Anti-tigit antibodies and uses of the same
WO2024015251A1 (en) 2022-07-15 2024-01-18 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
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CN119768155A (zh) 2022-09-14 2025-04-04 艾库斯生物科学有限公司 依曲地南的分散体
EP4602041A1 (en) 2022-10-14 2025-08-20 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
US20240180947A1 (en) 2022-10-20 2024-06-06 Arcus Biosciences, Inc. Lyophilized formulations of cd73 compounds
WO2024233360A1 (en) 2023-05-05 2024-11-14 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
EP4720055A1 (en) 2023-05-25 2026-04-08 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
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Also Published As

Publication number Publication date
IL276813A (en) 2020-10-29
CN111818928A (zh) 2020-10-23
MX2020009290A (es) 2020-09-28
AU2019229978A1 (en) 2020-10-15
UA127897C2 (uk) 2024-02-07
US12054500B2 (en) 2024-08-06
CA3091805A1 (en) 2019-09-12
IL276813B1 (en) 2024-05-01
CO2020012060A2 (es) 2021-01-18
SG11202008113RA (en) 2020-09-29
MY205512A (en) 2024-10-24
US20210002306A1 (en) 2021-01-07
BR112020017604A2 (pt) 2020-12-22
PH12020551352A1 (en) 2021-06-21
EA202092086A1 (ru) 2021-02-09
IL276813B2 (en) 2024-09-01
KR20200128117A (ko) 2020-11-11
CL2020002271A1 (es) 2021-04-09
KR102656571B1 (ko) 2024-04-11
ZA202006006B (en) 2025-02-26
AU2019229978B2 (en) 2024-05-30
WO2019173188A1 (en) 2019-09-12
EP3761992A1 (en) 2021-01-13
PE20210452A1 (es) 2021-03-08
EP3761992A4 (en) 2021-11-24
JP2021516237A (ja) 2021-07-01
CR20200445A (es) 2021-04-27

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