KR102595683B1 - 변형된 가이드 rna - Google Patents

변형된 가이드 rna Download PDF

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KR102595683B1
KR102595683B1 KR1020197019385A KR20197019385A KR102595683B1 KR 102595683 B1 KR102595683 B1 KR 102595683B1 KR 1020197019385 A KR1020197019385 A KR 1020197019385A KR 20197019385 A KR20197019385 A KR 20197019385A KR 102595683 B1 KR102595683 B1 KR 102595683B1
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nucleotides
modified
sgrna
region
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KR20190090848A (ko
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에이미 매디슨 로덴 스미스
데이비드 브이. 모리세이
월터 스트랩스
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인텔리아 테라퓨틱스, 인크.
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/35—Nature of the modification
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    • C12N2310/3533—Halogen
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020197019385A 2016-12-08 2017-12-08 변형된 가이드 rna Active KR102595683B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662431756P 2016-12-08 2016-12-08
US62/431,756 2016-12-08
PCT/US2017/065306 WO2018107028A1 (en) 2016-12-08 2017-12-08 Modified guide rnas

Publications (2)

Publication Number Publication Date
KR20190090848A KR20190090848A (ko) 2019-08-02
KR102595683B1 true KR102595683B1 (ko) 2023-10-31

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US (3) US11479767B2 (enExample)
EP (1) EP3551757A1 (enExample)
JP (3) JP7696694B2 (enExample)
KR (1) KR102595683B1 (enExample)
CN (2) CN119464289A (enExample)
AU (2) AU2017374044B2 (enExample)
BR (1) BR112019011509A2 (enExample)
CA (1) CA3046376A1 (enExample)
CO (1) CO2019007258A2 (enExample)
EA (1) EA201991369A1 (enExample)
IL (1) IL267024B2 (enExample)
MX (2) MX2025000703A (enExample)
MY (1) MY206324A (enExample)
PH (1) PH12019501262A1 (enExample)
SG (1) SG10202106058WA (enExample)
TW (1) TWI835719B (enExample)
WO (1) WO2018107028A1 (enExample)
ZA (1) ZA202007633B (enExample)

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