KR102595249B1 - 세포 치료를 위한 표적화된 리간드-페이로드 기반의 약물 전달 - Google Patents

세포 치료를 위한 표적화된 리간드-페이로드 기반의 약물 전달 Download PDF

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KR102595249B1
KR102595249B1 KR1020197026818A KR20197026818A KR102595249B1 KR 102595249 B1 KR102595249 B1 KR 102595249B1 KR 1020197026818 A KR1020197026818 A KR 1020197026818A KR 20197026818 A KR20197026818 A KR 20197026818A KR 102595249 B1 KR102595249 B1 KR 102595249B1
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필립 에스. 로우
맛두리 스리니바사라오
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퍼듀 리서치 파운데이션
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KR1020197026818A 2017-02-17 2018-02-17 세포 치료를 위한 표적화된 리간드-페이로드 기반의 약물 전달 Active KR102595249B1 (ko)

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US201762460118P 2017-02-17 2017-02-17
US62/460,118 2017-02-17
PCT/US2018/018557 WO2018152451A1 (en) 2017-02-17 2018-02-17 Targeted ligand-payload based drug delivery for cell therapy

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KR102595249B1 true KR102595249B1 (ko) 2023-10-27

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US (2) US12343403B2 (enExample)
EP (2) EP3583218B1 (enExample)
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CN (2) CN118634339B (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12343403B2 (en) 2017-02-17 2025-07-01 Purdue Research Foundation Targeted ligand-payload based drug delivery for cell therapy

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014100615A1 (en) 2012-12-20 2014-06-26 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
AU2017219859A1 (en) 2016-02-16 2018-08-09 Dana-Farber Cancer Institute, Inc. Immunotherapy compositions and methods
US12144850B2 (en) 2016-04-08 2024-11-19 Purdue Research Foundation Methods and compositions for car T cell therapy
CA3051481A1 (en) 2017-02-07 2018-08-16 Seattle Children's Hospital (dba Seattle Children's Research Institute) Phospholipid ether (ple) car t cell tumor targeting (ctct) agents
ES3010559T3 (en) 2017-02-28 2025-04-03 Endocyte Inc Compositions and methods for car t cell therapy
JP7549303B2 (ja) 2018-01-22 2024-09-11 エンドサイト・インコーポレイテッド Car t細胞の使用方法
CN111936518A (zh) 2018-02-06 2020-11-13 西雅图儿童医院(Dba西雅图儿童研究所) 对fl-ple标记的肿瘤表现出最佳的t细胞功能的荧光素特异性car
CN112105382A (zh) 2018-02-23 2020-12-18 恩多塞特公司 用于car t细胞疗法的顺序方法
JP7721436B2 (ja) 2018-04-12 2025-08-12 ウモジャ バイオファーマ インコーポレイテッド ウイルスベクター及びパッケージング細胞株
CN112399852A (zh) 2018-06-28 2021-02-23 达纳-法伯癌症研究所有限公司 固体和液体恶性肿瘤中多重抗原受体t细胞对多种抗原的靶向
JP7623935B2 (ja) * 2018-08-07 2025-01-29 パーデュー・リサーチ・ファウンデーション Car t細胞の若返り
KR20210129058A (ko) * 2019-01-23 2021-10-27 더 존스 홉킨스 유니버시티 비-면역억제성 fk506 유사체 및 이의 용도
CN114207135A (zh) 2019-06-11 2022-03-18 夏尔人类遗传性治疗公司 用于治疗由失调的血浆激肽释放酶介导的疾病的抗体的腺相关病毒载体递送
CA3150095A1 (en) * 2019-09-06 2021-03-11 Shirley O'dea IMMUNE CELL ENGINEERING FOR EX VIVO CELLULAR THERAPY APPLICATIONS
EP4048800A1 (en) 2019-10-23 2022-08-31 Shire Human Genetic Therapies, Inc. Adeno-associated virus vectors based gene therapy for hereditary angioedema
WO2022044024A1 (en) * 2020-08-31 2022-03-03 Ramot At Tel-Aviv University Ltd. Small molecule modulators of gsk-3 activity
CN116829595A (zh) 2020-12-16 2023-09-29 武田药品工业株式会社 用于治疗由失调的血浆激肽释放酶介导的疾病的抗体的腺相关病毒载体递送
CA3203105A1 (en) * 2020-12-22 2022-06-30 Michael H. Cardone Methods and compositions related to bcl2 and bim heterodimer antibodies
CN113462649B (zh) * 2021-05-27 2022-08-23 浙江大学 Mek抑制剂在减少car-t细胞耗竭和终末分化中的应用
IL310057A (en) * 2021-07-21 2024-03-01 Immunitybio Inc GENERATION OF CHIMERIC ANTIGEN RECEPTOR mRNA MOLECULES FOR EXPRESSION IN PRIMARY NK CELLS
CN116041545A (zh) * 2022-12-12 2023-05-02 南方医科大学 一种靶向荧光素或生物素的通用型car及其应用
WO2024206913A2 (en) * 2023-03-31 2024-10-03 Northwestern University Compositions for antigen-specific immune cell activation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070077197A1 (en) 1998-05-16 2007-04-05 Bracco International B.V. Metal Complexes Derivatized with Folate for use in Diagnostic and Therapeutic Applications
WO2016098078A2 (en) 2014-12-19 2016-06-23 Novartis Ag Dimerization switches and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9523469D0 (en) * 1995-11-16 1996-01-17 Sandoz Ltd Organic compounds
EP2371854B1 (en) 2001-03-09 2014-05-07 Board Of Regents, The University Of Texas System Induction of tumor immunity by variants of folate binding protein
WO2005103250A1 (ja) * 2004-04-26 2005-11-03 Takami Matsuyama 葉酸リセプターベータ(FR-β)に対する単クローン抗体を含有する治療薬
WO2011079227A1 (en) * 2009-12-23 2011-06-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
AU2010234459A1 (en) 2009-04-08 2011-11-03 The Regents Of The University Of California Human protein scaffold with controlled serum pharmacokinetics
US10683506B2 (en) 2015-04-10 2020-06-16 The Methodist Hospital System CD117 ligand-drug conjugates for targeted cancer therapy
WO2017027843A1 (en) * 2015-08-12 2017-02-16 Massachusetts Institute Of Technology Cell surface coupling of nanoparticles
WO2017123956A1 (en) * 2016-01-15 2017-07-20 Etubics Corporation Methods and compositions for t-cell immunotherapy
KR102613430B1 (ko) * 2016-10-19 2023-12-18 더 스크립스 리서치 인스티튜트 인간화된 표적화 모이어티 및/또는 최적화된 키메라 항원 수용체-상호작용 도메인을 갖는 키메라 항원 수용체 효과기 세포 스위치 및 이의 용도
JP7305539B2 (ja) * 2016-11-02 2023-07-10 ウニベルシテート バーゼル 細胞療法に使用するための、免疫学的に識別できる細胞表面変異体
EP3583218B1 (en) 2017-02-17 2025-04-16 Purdue Research Foundation Targeted ligand-payload based drug delivery for cell therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070077197A1 (en) 1998-05-16 2007-04-05 Bracco International B.V. Metal Complexes Derivatized with Folate for use in Diagnostic and Therapeutic Applications
WO2016098078A2 (en) 2014-12-19 2016-06-23 Novartis Ag Dimerization switches and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12343403B2 (en) 2017-02-17 2025-07-01 Purdue Research Foundation Targeted ligand-payload based drug delivery for cell therapy

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