ES3024357T3 - Targeted ligand-payload based drug delivery for cell therapy - Google Patents

Targeted ligand-payload based drug delivery for cell therapy Download PDF

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Publication number
ES3024357T3
ES3024357T3 ES18754879T ES18754879T ES3024357T3 ES 3024357 T3 ES3024357 T3 ES 3024357T3 ES 18754879 T ES18754879 T ES 18754879T ES 18754879 T ES18754879 T ES 18754879T ES 3024357 T3 ES3024357 T3 ES 3024357T3
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cell
cells
drug delivery
delivery platform
drug
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Spanish (es)
Inventor
Philip S Low
Madduri Srinivasarao
Boning Zhang
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Purdue Research Foundation
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Purdue Research Foundation
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    • AHUMAN NECESSITIES
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
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    • A61K2039/515Animal cells
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    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
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    • C07ORGANIC CHEMISTRY
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    • C12Y502/01Cis-trans-Isomerases (5.2.1)
    • C12Y502/01008Peptidylprolyl isomerase (5.2.1.8), i.e. cyclophilin

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ES18754879T 2017-02-17 2018-02-17 Targeted ligand-payload based drug delivery for cell therapy Active ES3024357T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762460118P 2017-02-17 2017-02-17
PCT/US2018/018557 WO2018152451A1 (en) 2017-02-17 2018-02-17 Targeted ligand-payload based drug delivery for cell therapy

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ES3024357T3 true ES3024357T3 (en) 2025-06-04

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ES18754879T Active ES3024357T3 (en) 2017-02-17 2018-02-17 Targeted ligand-payload based drug delivery for cell therapy

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US (2) US12343403B2 (enExample)
EP (2) EP4600267A3 (enExample)
JP (2) JP7288402B2 (enExample)
KR (1) KR102595249B1 (enExample)
CN (2) CN118634339B (enExample)
AU (1) AU2018221171B2 (enExample)
CA (1) CA3053534A1 (enExample)
ES (1) ES3024357T3 (enExample)
WO (1) WO2018152451A1 (enExample)

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CA3019835A1 (en) 2016-04-08 2017-10-12 Purdue Research Foundation Methods and compositions for car t cell therapy
US11649288B2 (en) 2017-02-07 2023-05-16 Seattle Children's Hospital Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
ES3024357T3 (en) * 2017-02-17 2025-06-04 Purdue Research Foundation Targeted ligand-payload based drug delivery for cell therapy
US11850262B2 (en) 2017-02-28 2023-12-26 Purdue Research Foundation Compositions and methods for CAR T cell therapy
CN120154716A (zh) * 2018-01-22 2025-06-17 恩多塞特公司 Car t细胞的使用方法
JP7774961B2 (ja) 2018-02-06 2025-11-25 シアトル チルドレンズ ホスピタル ディー/ビー/エイ シアトル チルドレンズ リサーチ インスティテュート フルオレセイン結合エーテルリン脂質(fl-ple)で標識された腫瘍に対して最適なt細胞機能を示すフルオレセイン特異的car
CA3091674A1 (en) 2018-02-23 2019-08-29 Endocyte, Inc. Sequencing method for car t cell therapy
BR112020020887A2 (pt) 2018-04-12 2021-04-06 Umoja Biopharma, Inc Vetores virais e linhagens celulares de empacotamento
CN112399852A (zh) 2018-06-28 2021-02-23 达纳-法伯癌症研究所有限公司 固体和液体恶性肿瘤中多重抗原受体t细胞对多种抗原的靶向
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